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Biomedical subjects

A Leone

Publications and source records attributed to A Leone.

180 records · Page 10Linked to original sources
PubMedDate not supplied

[Assessment of the presence of mutations of the epidermal growth factor receptors in tumors of various histologies].

Recent reports from US and Japan have established that mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (Egfr) occur in a subset of patients with lung cancer that respond to therapy with gefitinib, a TK inhibitor. To gain further insights into the role of Egfr in carcinogenesis of lung and tumors of diverse histology, that are currently under investigation with drugs of the same class, we have taken in examination a panel of tumors consisting in 110 pulmonary adenocarcinomas, 40 pulmonary squamous carcinomas, 40 gastric adenocarcinomas and 40 colorectal adenocarcinomas. The sequence analysis of exon 19 and 21 of the Egfr has allowed the identification of 10 cases exhibiting specific deletions in exon 19 and 1 case with point mutation in a conserved residue in exon 21. All Egfr mutations occur specifically in lung adenocarcinomas while tumors of different histology result unaffected. The rate of mutation affecting these other tumors is either very rare, involves different domains of the receptor or other tyrosine kinases. The molecular analysis of the Egfr gene can help identify patients that will benefit from gefitinib therapy.

ErbB Receptors↗
PubMedDate not supplied

[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer].

Molecular characterization of gastrointestinal cancer has greatly helped the definition of the key steps of the malignant transformation process and made it the best understood among the malignant cancers. Genetic influences on prognosis may have important implications for the management of the disease and help to design patient-tailored therapy. In order to acquire additional knowledge on this issue we have commenced an institutional study with the aim to identify the most frequent molecular alterations and make a correlation with the conventional histopathological parameters.

Colorectal Neoplasms↗
PubMedDate not supplied

Reiter's syndrome.

Explore the source record for details and available documents.

Adult↗
PubMedDate not supplied

[The role of portography with computed tomography in the diagnosis of liver metastases from colorectal neoplasms].

This study was performed to confirm the high sensitivity of CT during arterial portography (CTAP) versus US and dynamic CT in the diagnosis of liver metastases from colorectal cancer. Ninety patients with 108 colorectal cancers underwent US, dynamic CT and CTAP to investigate the presence of liver metastases. US depicted 39 metastases in 26 patients, dynamic CT 46 metastases in 29 patients and CTAP 54 lesions in 34 patients. CTAP detected 8 metastases missed at dynamic CT; 4 of them were < 1 cm in diameter, 3 ranged 1-2 cm and one metastasis > 2 cm in diameter. After preoperative investigations only 7 patients were considered for hepatic resection. At surgery, palpation and intraoperative US of the liver detected two more metastases in the same patients. Our experience, in agreement with recent studies, confirms CTAP as the most sensitive preoperative method in detecting liver metastases and its superiority to be most apparent in lesions < 1 cm in diameter. Therefore, we consider CTAP an essential imaging technique for planning the correct treatment of liver metastases.

Adult↗
PubMedDate not supplied

Diagnostic imaging of musculoskeletal tuberculosis.

In the last decade an increase in the incidence of tuberculosis has been observed, due in part to the growing number of AIDS-patients. Musculoskeletal involvement is observed in 1-3% of tuberculosis cases. Aim of this article is to describe the diagnostic imaging of musculoskeletal tuberculosis and in particular the diagnostic potentialities of conventional radiology, CT and MRI. The role of MRI in the early identification of vertebral infectious process, in the determination of its locoregional extension and sometimes in its characterization, is underlined. In peripheral osteoarticular tuberculosis both CT and MRI do not supply additional diagnostic information as compared to conventional radiology; the tuberculous process is of difficult differentiation from other degenerative, inflammatory or neoplastic processes; in any case very careful attention is mandatory to establish an early diagnosis.

Adult↗
PubMedDate not supplied

Diagnostic imaging of neurotuberculosis.

Neurotuberculosis is represented by different and possibly concomitant forms, of which the most frequent are tuberculous meningitis and parenchymal tuberculosis followed by cerebral miliary tuberculosis and the extremely rare tuberculous abscesses. Tuberculous meningitis is characterized by the presence of inflammatory meningeal exudate involving meningeal surfaces and CSF spaces with involvement of relative vascular and nervous structures. Most frequent complications are parenchymal infarction, hydrocephalus and mycotic aneurysms. Inflammatory meningeal exudate shows intense contrast enhancement. Parenchymal tuberculosis may directly involve the cerebral and/or medullary parenchyma as areas of cerebritis/myelitis with solid nodular lesions (tuberculomas) with a central area of caseating necrosis. Tuberculomas are characterized by intense nodular or ring enhancement.

Diagnostic Imaging↗