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Biomedical subjects

A Lenzi

Publications and source records attributed to A Lenzi.

133 records · Page 8Linked to original sources
PubMedDate not supplied

Correlation between tests for the detection of antibodies bound to the sperm surface.

Direct tests for antisperm antibody detection are considered one of the first steps in the screening of a suspected male immunological infertility especially when one of the assisted fertilization protocols is being considered. With these techniques we can detect the presence of antisperm antibodies bound to the sperm surface. In this work we report the results of a laboratory correlation study carried out on the three direct techniques: IgG-MAR Test, the IgG-Latex Sperm MAR Test and the IgG-IgA-IgM-Immunobead Test. We analyzed data on 96 subjects, examined in our laboratory for a suspected antisperm antibody pathology. The three techniques were carried out in a blind experimental protocol by different technicians and the main results can be summarized as a strict correlation with regard to percentage and degree of positivity and a poor correlation with regard to the localization of the marker of the immune reaction (red blood cells, latex particles, polyacrylamide spherules).

Antibodies, Anti-Idiotypic↗
PubMedDate not supplied

Immunological usefulness of semen manipulation for artificial insemination homologous (AIH) in subjects with antisperm antibodies bound to sperm surface.

The authors report trials carried out in the preparation of semen for homologous artificial insemination in subjects with antisperm autoantibodies. The tests have demonstrated that swim-up is not able to select spermatozoa free of antibodies bound to the sperm surface. All the experiments of migration, dilution, antigenic competition and cryoconservation, carried out to evaluate the theoretical possibility of a better recovery of non "immunologically compromised" spermatozoa, have confirmed such negative results both with the Immunobead Test and Cytofluorimetric analysis.

Autoantibodies↗
PubMedDate not supplied

Third ventricle intrinsic craniopharingioma. Case report.

A case of craniopharingioma developed and situated in the cavity of the third ventricle with no connections with the base of the skull is reported. The patient was a thirty-year-old man, who within a few months had developed a diencephalic syndrome followed by psychic disorders and intracranial hypertension. Cerebral scan: large area of accumulation in the supra and retrosellar region. Bilateral carotid angiogram: no pathological staining but the venous angle and the internal cerebral vein were elevated and shifted posteriorly. Pneumoencephalogram: free and normal basal cisterns; the third ventrical is almost totally filled by a mass; small dilatation of the lateral ventricles. Operation: right trans ventricular approach to the third ventricle. The tumour was the size of an apricot encapsulated with a smooth surface, and adherent to the wall of the third ventricle only in the region of the infundibulum. There was little bleeding and no cystic component. Total removal was performed except for a few millimeters of capsule in the infundibular region. The postoperative course was complicated by an irreversible diencephalic insufficiency with death on the 27th postoperative day. Autopsy clearly showed that the inferior surface of the brain in the diencephalic region was not involved by the mass which hystologically was doubtless a craniopharingioma. Only two other cases of craniopharingioma of the third ventricle were so far reported in the literature by Cashion and Young in 1971.

Adult↗
PubMedDate not supplied

Intraventricular and intravenous use of amphotericin B in a case of non-surgical cerebral aspergillosis.

After a short review of the literature regarding aspergillosis, the authors report a case of a 7-year-old child suffering from cerebral aspergillosis with disseminated lesions. The authors emphasize the use of amphotericin B both intraventricularly and intravenously to obtain a longer survival when surgery is impossible because of the presence of multiple abscessual lesions in central nervous system. Authors' experience shows that the intraventricular administration of amphotericin B is well tolerated and does not cause collateral effects of the parenteral way.

Amphotericin B↗
PubMedDate not supplied

L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility.

The aim of the study described here was to evaluate any possible effect of L-carnitine on spermatozoal motility in a group of patients with unexplained asthenozoospermia in four different infertility centres. One hundred patients received 3 g d-1 of oral L-carnitine for 4 months. Sperm parameters were studied before, during and after this treatment. Motility was also studied by means of a computer-assisted sperm analysis. The results of the study indicate that L-carnitine is able to increase spermatozoal motility, both in a quantitative and in a qualitative manner (per cent motile spermatozoa increased from 26.9 +/- 1.1% to 37.7 +/- 1.1% [P < 0.001]; per cent spermatozoa with rapid linear progression increased from 10.8 +/- 0.6% to 18.0 +/- 0.9% [P < 0.001]; mean velocity increased from 28.4 +/- 0.6 microns s-1 to 32.5 +/- 0.8 microns s-1 [P < 0.001]; linearity index increased from 3.7 +/- 0.1 to 4.1 +/- 0.1 [P < 0.001], especially in the subgroup of patients with poor rapid linear progression of spermatozoa (per cent of motile spermatozoa increased from 19.3 +/- 1.9% to 40.9 +/- 1.4% [P < 0.001], and per cent of spermatozoa with rapid linear progression increased from 3.1 +/- 0.4% to 20.3 +/- 1.6% [P < 0.001]) An increase in spermatozoal output was also observed (total number of ejaculated spermatozoa increased from 142.4 +/- 10.3 10(6) to 163.3 +/- 11.0 x 10(6) [P < 0.001]). The authors conclude that oral administration of L-carnitine may improve sperm quality at least in patients with idiopathic asthenozoospermia.

Adult↗