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Biomedical subjects

A Lemoine

Publications and source records attributed to A Lemoine.

At least 73 records · Page 4Linked to original sources
PubMed1986

Reference intervals for vitamins B1, B2, E, D, retinol, beta-carotene, and folate in blood: usefulness of dietary selection criteria.

Reference intervals for normal concentrations in blood of vitamins B1, B2, E, D, retinol, beta-carotene, and folic acid were determined from a selected sample of people attending a Health Examination Center or being examined in occupational health services in France. This reference sample consisted of 362 men and women, ages 18 to 44 years, selected according to the main variation factors known for the vitamins studied: consumption of tobacco and alcohol, ponderal index (relating height and weight), use of drugs and oral contraceptives, and past history of surgical or medical treatment. Reference intervals were determined for each sex. Vitamin B1 (erythrocyte transketolase activity), plasma retinol, and folic acid values in whole blood are significantly higher in men than in women (p less than 0.001), but vitamin B2 (activation of erythrocyte glutathione reductase) and plasma beta-carotene values are significantly higher in women (p less than 0.001 and less than 0.01 respectively). Dietary intake of vitamins produced no significant displacement of the reference values. For each vitamin we discuss the other major sources of variation factors and the usual values reported in the literature.

Adolescent↗
PubMed1985

"ESVITAF". Survey on the vitamin status of the French: relationships between nutrient intake and biochemical indicators.

The relationships between dietary data and biochemical nutritional status for vitamins B1, B2, A, E, beta-carotene, folic acid and iron have been studied using data from a survey conducted on 710 adults. Significant correlations were found between riboflavin intake and biochemical values for males only (r = -0.105, p less than or equal to 0.05), between beta-carotene intake and plasma beta-carotene (r = 0.232, for males and r = 0.292 for females, p less than or equal to 0.001), and between iron intake and plasma iron for males only (r = 0.115, p less than or equal to 0.05). Concerning nutrient densities, correlations were significant between dietary riboflavin and biochemical measure (r = 0.163, p less than or equal to 0.01 for males, r = -0.135, p less than or equal to 0.05 for females), between vitamin A intake (expressed in retinol equivalent) and beta-carotene (r = 0.212, p less than or equal to 0.001 for males, r = 0.157, p less than or equal to 0.01 for females) and for males only, between dietary iron and hemoglobin (r = 0.144, p less than or equal to 0.01). The dietary data for each nutrient were examined for their sensitivity, specificity and predictive values in identifying subjects with substandard or overstandard biochemical values. For all nutrients the positive predictive value percentage was always below 25%, the negative predictive value percentage always under 75%.

Adolescent↗
PubMed1981

Red cell filterability and metabolic state in diabetic subjects with macro-angiopathy.

In twenty control subjects, twenty diabetic patients without macro-angiopathy and forty diabetic patients with an acute and severe arteriopathy of lower limbs, we studied the red cell filterability (TFE) on total blood, the 2-3 diphosphoglycerate level (2-3 DPG) and the Adenosine Triphosphate level (ATP). The diabetic's impairement of the red cell filterability and ATP level are all the more important than the subject is suffering from an acute arteriopathy of lower limbs. For the same subjects, we notice that the 2-3 DPG level increases significantly. The filterability is related to the ATP red cell concentration. An ATP depletion produces an increase membrane rigidity and a minor filterability. These findings strongly suggest a relation that can exist between the red cell metabolic state and filterability in diabetic population with or without macroangiopathy.

2,3-Diphosphoglycerate↗
PubMed1981

Pharmacological influences of pentoxifylline on red cell filterability and 2-3 diphosphoglycerate.

The diabetic's impairment of the red cell filterability is all the more important if the diabetic subject is suffering from an acute and progressive lower limb arteriopathy. Red cell 2-3 diphosphoglycerate (2-3 DPG) increases when red cell filterability decreases among these patients. Pentoxifylline (i.v. 600 mg per day) produces a rapid initial improvement of red cell filterability and then increases red cell 2-3 DPG level.

2,3-Diphosphoglycerate↗
PubMed1981

[Arthroplasty of the hip using a double cup].

In this double-cup arthroplasty, only the acetabular cup is sealed with cement; the femoral cup is simply implanted into the femoral head and neck. This operation was performed on 67 hips. Complications were limited to one hip dislocation, one break in cemented seal with ossification, one isolated massive ossification, and one fracture of the femoral neck in a case of polyarthritis. In 45 of these cases, follow-up has been continued for at least one year. X-ray signs of injury are frequent and seen in one out of two cases, but are no more frequent than in classical total prothesis and are therefore not alarming. The result of this technique with respect to pain is the same as for total prothesis. Mobility of the hip is maintained and is markedly improved when the hip was stiff prior to the operation. The major indication for this operation is osteoarthritis of the hip in patients 40 to 65 years of age for whom medical treatment is ineffective and where osteotomy cannot be performed. One fundamental point must be underlined: this technique must not jeopardize possible later surgery for total prothesis, and surgical technique must therefore be adapted with this in mind.

Adult↗
PubMed1980

Vitamin B1, B2, B6, and C status in hospital inpatients.

The status of vitamin B1, B2, B6 and C was investigated in 656 hospital inpatients by means of a dietary interview, biochemical studies, and clinical investigation. The daily intake was lower than the Recommended Dietary Allowance for vitamin B1 in 57%, B2 in 47%, B6 in 53%, and C in 9% of the patients; it was less than half the Recommended Dietary Allowance in 19, 12, 15, and 3%, respectively. A biochemical deficiency was observed in 25% of the patients for vitamin B1, in 11% for B2, in 25% for B6, and in 14% for C. On the basis of the parameters selected for this study, the biochemical vitamin status, the dietary vitamin intake, and the clinical symptoms correlated significantly with each other except in the case of vitamin B6.

Adult↗
PubMed1980

Impairment of memorization by high doses of pyridoxine in man.

Two controlled trials were performed successively to evaluate the effect of high doses of oral pyridoxine on brain performance in man. In trial I, medical students volunteered to take 100 mg, 500 mg of pyridoxine a day or placebo for 10 days. A digit coding test was performed before, and at the end of the treatment period and a third 15 days later. The improvement of performance from the first to the third test (learning effect) was significantly better in the placebo group than in the B6 treated groups. This could be attributed to memorization of skills. Trial II was performed in obese patients starting a low calorie diet in whom vitamins are routinely prescribed. Performance in a work recognition test and in a visual retention test was lower for the group receiving 1 g of pyridoxine a day. Thus, high doses of oral pyridoxine are likely to impair memorization in man. Disturbances of neuro-transmitter metabolism such as increase of GABA production might explain the effect. As the benefit of high doses of pyridoxine has not been well-documented and as the study has suggested that undesired effects may indeed exist, the widespread use of such doses is questionable.

Adult↗
PubMed1975

[Bacteriostatic and bacteriacidal activity of hydroxy-9 ellipticine in vitro].

9-Hydroxy-ellipticine shows a clear effect against bacterial development. This effect depends essentially upon the bacterial species. Two groups can be differentiated: Group I with resisting species composed by negative Gram Bacilli (Enterobacteria and Pseudomonas); Group II with sensitive species formed by Coccus, positive Gram Bacilli, Mycobacterium tuberculosis and Anaerobes.

Alkaloids↗