Biomedical subjects

A Leimgruber

Publications and source records attributed to A Leimgruber.

23 records · Page 2Linked to original sources

PubMed1980

Effect of one gold salt, of betamethasone, and of aspirin on the chemotaxis of human neutrophils measured in vitro.

The effects of 1 gold salt, of betamethasone, and of acetylsalicylate on the chemotaxis of human neutrophils were compared in normal volunteers by means of a modified Boyden chamber. The gold salt inhibited chemotaxis by reducing both cell migration capacity and the capacity of plasma to attract the cell. Betamethasone reduced cell migration capacity, but not the chemoattractant capacity of plasma. Acetylsalicylate had no effect on these functions.

Aspirin↗

PubMed1978

[Effect of anti-inflammatory agents on chemotaxis of human neutrophils studied in vitro].

Using a modified Boyden chamber the effect of three antiinflammatory drugs on the chemotaxis of human neutrophils has been tested in vitro. Gold salt produced a reduction of both neutrophil migration and the ability of plasma to attract this cell. Betamethasone decreased chemotaxis by an action on the cell itself but not on the plasma. Aspirin had no effect on this function. These data suggest that antiinflammatory drugs act through different mechanisms and that the reduction of neutrophil chemotaxis may contribute to the antiinflammatory action of gold salts.

1-Propanol↗

PubMed1975

[Chemotaxis of human polymorphonuclear cells in vitro. Study of inflammatory rheumatic diseases].

Sixty-eight determinations of leukocyte chemotaxis were performed in 42 patients suffering from systemic lupus erythematodes (17 cases), rheumatoid arthritis (15 cases) and scleroderma (10 cases). In contrast to the results of others, this study showed a deficiency in only 15 of 42 cases (35.7%). Impairment of chemotaxis was always transitory and demonstrable only during acute phases of disease. Intrinsic deficiency of PMN leukocytes as well as deficiency of plasma factors were related to the clinical and biological course of the disease and to the treatment.

Antibodies, Antinuclear↗

PubMedDate not supplied

The potential of bronchoalveolar lavage in the prognosis and treatment of connective-vascular diseases.

Interstitial lung disease (ILD) has a poor prognosis in a significant number of patients with connective vascular disease (CVD). By bronchoalveolar lavage fluid (BALF) analysis, ILD may be demonstrated in nearly half of patients with CVD prior to any alteration in lung function or chest radiograph. High neutrophil and eosinophil counts are usually associated with a high risk of functional deterioration, whereas the presence of increased lymphocytes correlates with a better outcome. Furthermore, initiation of therapy (steroids and/or cytotoxic agents) early in the course of disease is predictive of a better response. Cell differentials in bronchoalveolar lavage (BAL), together with measurements of cell by-products and techniques such as high resolution computed tomography, may contribute in the near future to help characterize those patients with the highest risks of evolution to pulmonary fibrosis, and to determine the most favorable time in the course of the disease for the initiation of therapy.

Bronchoalveolar Lavage↗

PubMedDate not supplied

[Chemotaxis of human granulocytes "in vitro". Study of inflammatory rheumatic diseases].

68 mesures of chemiotaxis of the blood granulocytes carried out in 42 patients suffering from systemic lupus erythematosus (SLE-17 cases), rheumatoid polyarthritis (RP-15 cases) and sclerodermia (SD-10 cases) showed a deficit in 15 cases. The deficit seen is cellular or plasmatic in the former two conditions (SLE & RP) but purely cellular in the sclerodermia. In SLE there is a relationship between the chemiotaxic deficit and a renal attack or a reduction in complement. In RP a relationship was established between chemiotaxis and a marked rise in VS (?) (synovial volume ?) and the rheumatoid factor titre. A relationship with a visceral attack was seen in SD. Contrary to other studies reporting a constant chemiotaxic deficit in these conditions, the present work shows that the deficit : 1. exists in only a minority of patients ; 2. is transitory ; 3. is not associated solely with granulocytes but may also be related to plasmatic factors. The diminution of chemiotaxis which is always seen in the acute phase of the illness may result from the reduction on the quantities of less reactive granulocytes in the peripheral blood ; the most reactive pass out through the walls of the vessels and move towards the foci of inflammation.

Adult↗