Search PubMed⌕ Search

Biomedical subjects

A Lehmann

Publications and source records attributed to A Lehmann.

At least 163 records · Page 9Linked to original sources
PubMed1982

[Current determination of ovulation time. 1. Rapid LH determination in serum and urine].

Short-term recording of LH rise is a possible approach to ovulation forecast. Hormone values in serum and four-hour urine can be obtained in three and half hours by modification of a commercial radio-immunological LH test. The results were compared with data obtained from the HI Gonavis test. Observable LH rise can be detected between three and six hours earlier by LH serum measurement, as compared to collected urine. Suitable information may be obtained also from LH urine assay, a non-invasive method of ovulation prediction.

Female↗
PubMed1980

Calcium and oxalate concentrations in human renal tissue: the key to the pathogenesis of stone formation?

On the basis of what we know about urinary supersaturation and particle growth inhibitors stone formation is unlikely to start from free crystalluric particles in the renal tubule. Therefore, the object of this study is to report data on the intrarenal distribution of calcium and oxalate in man and to examine a possible relationship between calcium and oxalate concentrations in the renal tissue and stone formation. Fresh human renal tissue was obtained at operation from 7 subjects. The calcium concentrations in the papilla, medulla and cortex were measured by atomic absorption spectrophotometry. A radioenzymatic procedure was used to determine the corresponding oxalate concentrations. Significantly higher concentrations of calcium and oxalate were observed in the papilla compared to the medulla. The medulla, in turn, contained higher concentrations than the cortex. Calcium and oxalate concentrations were 6 and 25 times higher in the normal papilla than in the urine, respectively. The ion product of calcium oxalate concentrations in the human renal tissue have not been investigated, although the frequent finding of calcification in the renal papilla suggests that they may exist. The observed intrarenal calcium and oxalate concentration gradients seem to be a significant mechanism in the pathogenesis of papillary calcification and a strong indication for renal stone formation to start from fixed crystalluric particles in the papilla.

Calcium↗
PubMed1980

Intrarenal distribution of oxalic acid, calcium, sodium, and potassium in man.

The renal papilla in man has been shown to contain a high concentration of oxalate (5 . 5 +/- 0 . 8 mmole/kg wet weight, mean +/- SEM, n = 7 kidneys), and that there is a significant concentration gradient between oxalate in the papilla and that of the medulla (0 . 4 +/- 0 . 08, P < 0 . 05) and the cortex (0 . 3 +/- 0 . 06, P < 0 . 05). Significant calcium and sodium gradients between renal papilla and medulla and cortex were confirmed and parallel that of oxalate. Potassium showed a significant decrease in the papilla (33 . 1 +/- 0 . 9) as compared to the medulla (42 . 1 +/- 1 . 9 P < 0 . 05). The concentrations of oxalate and calcium in the papilla were respectively 25-fold and 6-fold higher than the urinary concentration of oxalate and calcium. It is concluded that these high concentrations of oxalate and calcium in the renal papilla are related to the formation of Randall's plaques and may be an essential factor in the pathogenesis of renal stones which is still far from clear.

Calcium↗
PubMed1980

The primary structure of histone H1 from sperm of the sea urchin Parechinus angulosus. 2. Sequence of the C-terminal CNBr peptide and the entire primary structure.

The primary structure of sperm histone H1Parechinus has been determined. H1Parechinus consists of a polypeptide chain of the following 248 amino acid residues: Pro-Gly-Ser-Pro-Gln-Lys-Arg-Ala-Ala-Ser-Pro-Arg-Lys-Ser-Pro-Arg-Lys-Ser-Pro-Lys-Lys-Ser-Pro-Arg-Lys-Ala-Ser-Ala-Ser-Pro-Arg-Arg-Lys-Ala-Lys-Arg-Ala-Arg-Ala-Ser-Thr-His-Pro-Pro-Val-Leu-Glu-Met-Val-Gln-Ala-Ala-Ile-Thr-Ala-Met-Lys-Glu-Arg-Lys-Gly-Ser-Ser-Ala-Ala-Lys-Ile-Lys-Ser-Tyr-Met-Ala-Ala-Asn-Tyr-Arg-Val-Asp-Met-Asn-Val-Leu-Ala-Pro-His-Val-Arg-Arg-Ala-Leu-Arg-Asn-Gly-Val-Ala-Ser-Gly-Ala-Leu-Lys-Gln-Val-Thr-Gly-Thr-Gly-Ala-Ser-Gly-Arg-Phe-Arg-Val-Gly-Ala-Val-Ala-Lys-Pro-Lys-Lys-Ala-Lys-Lys-Thr-Ser-Ala-Ala-Ala-Lys-Ala-Lys-Lys-Ala-Lys-Ala-Ala-Ala-Ala-Lys-Lys-Ala-Arg-Arg-leads to Lys-Ala-Lys-Ala-Ala-Ala-Lys-Arg-Lys-Ala-Ala-Leu-Ala-Lys-Lys-Lys-Ala-Ala-Ala-Ala-Lys-Arg-Lys-Ala-Ala-Ala-Lys-Ala-Lys-Lys-Ala-Lys-Lys-Pro-Lys-Lys-Lys-Ala-Ala-Ala-Lys-Lys-Ala-Lys-Lys-Pro-Ala-Lys-Lys-Ser-Pro-Lys-Lys-Ala-Lys-Lys-Pro-Ala-Lys-Lys-Ser-Pro-Lys-Lys-Lys-Lys-Ala-Lys-Arg-Ser-Pro-Lys-Lys-Ala-Lys-Lys-Ala-Ala-Gly-Lys-Arg-Lys-Pro-Ala-Ala-Lys-Lys-Ala-Arg-Arg-Ser-Pro-Arg-Lys-Ala-Gly-Lys-Arg-Arg-Ser-Pro-Lys-Lys-Ala-Arg-Lys. The protein consists of three domains. Compared to other H1 and H5 histones, there is a very similar hydrophobic central domain and the carboxyl-terminal domain is very rich in lysine and alanine. H1Parechinus is similar to H5 histones in that the carboxyl-terminal domain also contains many arginine residues close to the carboxyl terminus. The carboxyl-terminal domain of H1Parechinus appears to have been constructed by a series of variable duplications. The amino-terminal domain of H1Parechinus is longer and quire different to that of other H1 and H5 histones and is characterized by a repeating tetrapeptide of the general type Ser-Pro-(basic)2. The known sequence of a histone H1 gene from Psammechinus miliaris [Schaffner, W. et al. (1978) Cell, 14, 655-671] is compared to the sequence of H1Parechinus. Again the central hydrophobic domains are similar whereas the amino terminal domains are very different. The functions of the various domains of sperm histone H1Parechinus are discussed.

Amino Acid Sequence↗
PubMed1980

[Functional treatment of humerus fractures by Sarmiento's method].

We treated 14 cases of fracture of the shaft of the humerus with the functional method published by A. SARMIENTO in 1977, consisting of a plastic sleeve and early introduction of functional activity. The results were excellent, healing time and restoration of motion have been rapid.

Adult↗
PubMed1978

[Hemostaseological problems with artificial heart-valves (author's transl)].

The risk of thrombo-embolic episodes in patients with artificial heart-valves has been reduced by means of improved material and of anticoagulation. Kinetic studies, however, indicate a correlation between the risk of thrombo-embolism and an increased platelet turnover. Therefore a therapy with platelet aggregation inhibitors has been recommended. In addition to an increased platelet turnover, other risk factors have been evaluated like the material, the number, and the position of the artificial valves, the time elapsed since surgery, cardiologic disease, and anamnestic criteria. We proposed a semiquantitative risk score taking in account all these risk factors to avoid unnecessary coagulation treatment and to recommend antiplatelet therapy, where necessary. This risk score could be a basis to evaluate controlled studies.

Anticoagulants↗