Search PubMed⌕ Search

Biomedical subjects

A Ledo

Publications and source records attributed to A Ledo.

At least 37 records · Page 2Linked to original sources
PubMed1995

Infrequent expression of protein p53 in epidermotropic variants of cutaneous T-cell lymphoma.

Although diverse types of lymphomas have been examined for immunohistochemical detection of p53 protein, little information is available with regard to p53 protein expression in CTCL. We analyzed cutaneous biopsy specimens of 22 patients with the diagnoses of mycosis fungoides or Sézary syndrome with polyclonal rabbit anti-p53 antiserum CM-1. Staining of neoplastic cells was observed only in two patients with advanced disease. Overexpression of p53 protein does not seem to be a major feature of either mycosis fungoides or Sézary syndrome.

Adult↗
PubMed1995

Plasma levels of 8-methoxypsoralen after bath-PUVA for psoriasis: relationship to disease severity.

Plasma levels of 8-methoxypsoralen (8-MOP) were determined by high-pressure liquid chromatography in 19 patients with psoriasis who were receiving bath-PUVA treatment, at different time points after the psoralen bath. The levels of 8-MOP varied between < 5 ng/ml (lower limit of detection) and 34 ng/ml, and we found a relationship between the plasma psoralen levels and the severity of the disease.

Administration, Cutaneous↗
PubMed1995

Pityriasis rubra pilaris and human immunodeficiency virus infection.

Recently, the occurrence of pityriasis rubra pilaris (PRP) has been reported in patients with HIV infection. It presents different clinical features, and has a poorer prognosis, than the classical adult type of PRP. We report the occurrence of severe PRP in an HIV-infected patient, and review the previously reported cases of this association. We propose the designation of a new category of PRP (type 6), characterized by the presence of HIV infection, usually without immunosuppression, a poor prognosis and response to treatment, and the development of nodulocystic and lichen spinulosus lesions.

Adult↗
PubMed1995

Pachydermodactyly: a case report.

Pachydermodactyly is an uncommon variant of digital fibromatosis that has previously been related to knuckle pads. It is a benign condition that needs no investigation for an underlying systemic disease. We present a new case of pachydermodactyly and comment on the available literature.

Adolescent↗
PubMed1994

Minocycline hydrochloride hyperpigmentation complicating treatment of pyoderma gangrenosum.

Minocycline-associated hyperpigmentation is an uncommon side effect. We report the case of a patient with pyoderma gangrenosum successfully treated with oral minocycline but complicated by marked hyperpigmentation in his pyoderma gangrenosum and acne scars. One of the clinical forms of minocycline hyperpigmentation includes dark-blue or black macules in depressed acne scars or other sites of skin inflammation; this pattern seems to be independent of the total cumulative dose and the skin process.

Adult↗
PubMed1994

CO2, argon, and pulsed dye laser treatment of angiofibromas.

BACKGROUND: Tuberous sclerosis is a complex disorder of hamartoma formation in many organs, particularly the skin, brain, eye, kidney, and heart. The characteristic skin lesions are angiofibromas (AF), the shagreen patch, periungual fibromas, and "ash-leaf" white macules. Treatment for AF has previously included electrocoagulation, electrodesiccation and curettage, dermabrasion, excision, cryosurgery, and oral 13-cis retinoic acid. Both argon and CO2 lasers have been used in isolated cases to treat AF. OBJECTIVE: The purpose of this work is the study of the application of three different lasers in the treatment of facial AF. METHODS: Ten patients with facial AF were treated with CO2, argon, and pulsed dye lasers. Patients' AF were graded with regard to the size and color of the lesions. A 2-3-cm2 test was assayed on the face of all patients with each laser before performing a complete treatment and in order to choose the best laser. RESULTS: Results were considered excellent in seven patients and good in three patients, with decrease of erythema and flattening of the AF. Minimal scarring was noted in two patients. Transient erythema was observed in patients treated with the CO2 laser. All patients or their parents considered the treatment cosmetically satisfactory. CONCLUSION: We found the CO2 laser to be a better therapeutic tool than the argon laser to treat AF, especially in those patients with multiple and protuberant AF. The argon laser would be more useful in those patients with very red AF and light complexion, and the pulsed dye laser in those with very red and flat AF.

Adolescent↗
PubMed1994

Mucocutaneous leishmaniasis and HIV.

Mucocutaneous leishmaniasis is a rare disease in Europe. Relapses after treatment are more frequent than in visceral leishmaniasis. HIV patients infected by Leishmania have frequently visceral involvement, and responses to treatment are poor. Mucocutaneous leishmaniasis in HIV-infected patients has rarely been reported. A patient with centrofacial granuloma was diagnosed as having mucocutaneous leishmaniasis; simultaneously HIV infection was detected. To our knowledge this is the first case acquired in Europe. Intravenous meglumine antimonate 20 mg/kg/day for 28 days was proven to be useful.

AIDS-Related Opportunistic Infections↗
PubMed1993

[Facial angioma and the Sturge-Weber syndrome: a study of 121 cases].

BACKGROUND: We show a study in 121 patients with port-wine stain (PWS) over the areas of trigeminal nerve sensory innervation, and we analyzed the relations between this distribution, sex and the neuro-ocular disease. METHODS: The population included 68 women between 12 months and 73 years (mean, 23 years; standard deviation, 13.7 years) and 53 men between 12 months and 50 years (mean, 18 years; standard deviation, 12 years). Chi-square test and Fisher test were performed in order to assess statistical significance of our results. RESULTS: Facial port-wine stains (PWS) were predominantly distributed over the area of innervation of the maxillary branch (V2) of the trigeminal nerve (88% of patients), either isolated or simultaneously involving ophthalmic (V1) and/or mandibular branch (V3). Of the unilateral PWS (86%), 10% were also extrafacially distributed. However, bilateral PWS (14%) extended extrafacially in 53% of the patients. Moreover, the number of patients with extrafacial PWS was increased among those with PWS over V3 (50%). Glaucoma and epilepsy were present in 23 (17%) and 17 (14%) patients, respectively. In all of them PWS affected V1. Among the 19 patients with bilateral PWS, nine of them developed glaucoma and five, epilepsy. Epilepsy was more frequent in men (26%) than in women (4%). CONCLUSIONS: Statistical analysis showed: 1) the PWS is preferentially distributed over the maxillary branch of the trigeminal nerve, 2) bilateral PWS significantly increases the frequency of cutaneous extrafacial PWS, 3) the presence of PWS over the mandibular branch of trigeminal nerve carries a higher risk of cutaneous extrafacial presence of the angioma, 4) only those patients with PWS over the ophthalmic branch may develop glaucoma and/or epilepsy, 5) extrafacial PWS is associated with a higher frequency of glaucoma, 6) men have a higher risk of developing epilepsy than women.

Adolescent↗