Intestinal injury associated with spiramycin therapy of Cryptosporidium infection in AIDS.
Two of three patients treated with high doses of spiramycin for Cryptosporidium infection developed acute intestinal injury. Spiramycin at high doses may be directly toxic to the intestinal epithelium and thus may have limited utility as therapy for cryptosporidiosis in AIDS patients.
Acquired Immunodeficiency Syndrome↗