Search PubMed⌕ Search

Biomedical subjects

A Lazarus

Publications and source records attributed to A Lazarus.

At least 109 records · Page 6Linked to original sources
PubMed1987

Cellular signal transduction and the reversal of malignancy.

Animal cells contain only a few defined molecular systems that transduce hormonal and growth signals from the external environment to the intracellular milieu to regulate cellular growth and differentiation. Among the most ubiquitous of these "second messenger" pathways are those utilizing cyclic AMP and phosphatidylinositide turnover. The former activates protein kinase A, while the latter leads to the activation of protein kinase C and mobilization of intracellular calcium. Lesions induced by oncogenes in signal transduction systems may be responsible for the cancerous transformation of cells. In many tumor cell lines, including some transformed by the ras and sis oncogenes, activation of protein kinase A by elevation of cyclic AMP or activation of protein kinase C by addition of phorbol esters can restore many normal aspects of growth and morphology. Such "reverse transformation" is accompanied by the phosphorylation of unique cellular proteins and alterations in the phosphoinositide cycle. Molecular mechanisms by which activation of signal transduction systems can attenuate the malignant phenotype are considered in the context of cellular growth and differentiation.

Animals↗
PubMed1986

Resolution of thyroid-induced schizophreniform disorder following subtotal thyroidectomy: case report.

Psychoses due to thyrotoxicosis are typically affective in nature. We report on a schizophreniform psychosis in a woman with Graves' disease whose symptoms abated following subtotal thyroidectomy. Surgical thyroidectomy should be considered in thyrotoxic patients who are unresponsive to medical therapy or who manifest unremitting or life-threatening psychotic behavior, especially if long-term compliance required for medical therapy appears unlikely.

Adult↗
PubMed1986

Treatment of neuroleptic malignant syndrome with electroconvulsive therapy.

A case of neuroleptic malignant syndrome unresponsive to supportive medical therapy was successfully treated by electroconvulsive therapy. Electroconvulsive therapy may offer a safe and rapidly effective intervention in cases of neuroleptic malignant syndrome complicated by high fever and severe muscular rigidity which do not improve with supportive care.

Electroconvulsive Therapy↗
PubMed1986

The neuroleptic malignant syndrome: a review.

An overview of the neuroleptic malignant syndrome (NMS) is presented. Its clinical manifestations, pathogenesis, and current treatment are discussed. An increased appreciation of the syndrome may result in more timely interventions and reduce morbidity and mortality in this disorder.

Humans↗
PubMed1986

Sarcoidosis developing during therapy for breast cancer.

Two women with breast carcinoma developed bilateral hilar adenopathy, with pulmonary infiltrate in one, during treatment for breast carcinoma. There was strong suspicion of metastatic disease from breast carcinoma. However, biopsy of a mediastinal node in first patient and transbronchial specimen biopsy in the second patient proved the diagnosis to be sarcoidosis. In one patient improvement was noted without therapy, and in the other improvement was noted with steroid treatment.

Adult↗
PubMed1986

Therapy of neuroleptic malignant syndrome.

The neuroleptic malignant syndrome (NMS) is an under-recognized yet sometimes fatal complication of antipsychotic drug therapy. NMS is comprised of hyperthermia, rigidity, autonomic disturbances, and altered consciousness. Until recently, there was no specific therapy for NMS other than discontinuing the offending neuroleptic and providing symptomatic treatment. However, 4 drugs (dantrolene and the dopamine agonists amantadine, bromocriptine, and carbidopa/levodopa) have clearly emerged to merit consideration in the therapy of NMS. The literature on their use in this disorder, either alone or in combination, is reviewed. The combination of dantrolene (a peripheral muscle relaxant) and post-synaptic dopamine agonists may prove the most effective in this condition.

Amantadine↗
PubMed1985

Heatstroke in a chronic schizophrenic patient treated with high-potency neuroleptics.

A fatal case of heatstroke occurred in a chronic schizophrenic patient treated with high-potency neuroleptics. The author differentiates heatstroke from other hyperthermic syndromes related to treatment with major tranquilizers and suggests that an awareness of factors that predispose psychiatric patients to the development of heatstroke may aid in its prevention.

Antipsychotic Agents↗
PubMed1984

Primary health care: a training experience with the community.

In 1982-83 we organized training schemes for various people involved in primary health care at local authority level. These schemes were part of the pattern of similar activity carried out with trained professional staff of the mother-and-child care and school health services. What was new was the participation of non-professional users (or their representatives) of health services, i.e. local politicians, representatives of associations, etc. The training sessions brought together 20-25 participants for two or three days and there were occasionally follow-up meetings of one or two days. The participants, divided into small groups of five or six, played an active part in the meetings, which were based on known information about the local authority area and the participants' own contributions. The initial task was the identification of health problems. For this to be a relevant exercise, the many political, cultural and personal factors which influence people's lives had to be considered. The fact is that the usual epidemiological data are inadequate if they are based solely on a review of symptoms and their distribution among the population as a whole. The procedure begins with the group concerned, and priority in selecting problems is decided with and within the group itself. The solutions that are required will thus be based on the experience and reasoning of the people themselves. A procedure of this type ought to show the factors which affect the community (working conditions, environment, habitat, cultural background, etc.) and which influence health. If we understand the structures of the community and the resources at its disposal, we can adapt our response accordingly. In assessing our experiment, we found that the training sessions produced a local awareness and a mutual recognition of the various participants, both professional and non-professional. Each person began to understand his limits since his role was constantly being reviewed. At the same time the requirements voiced by health care users became more apparent to the professionals with their preconceived ideas about people's needs and requirements.

Community Health Services↗