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Biomedical subjects

A Lazarov

Publications and source records attributed to A Lazarov.

At least 19 recordsLinked to original sources
PubMed1977

[Struma ovarii].

Explore the source record for details and available documents.

Adult↗
PubMed1977

[Onset of menarche in Skopje. (Comparative studies on 22,727 women up to the 6th decade of age)].

Studies of menarche in Skopje have shown that its secular trend is significantly more pronounced in younger than in older generations. While in the young it amounts to 2.5--3 months per decade, in the elderly it is up to one month per decade. The total acceleration in the course of this century has proved to be 13.5 months. The earliest menarche was recorded in Romanies (13.46 +/- 0.92), the latest in Albanians (14.05 +/- 1.22), while Macedonian girls are somewhere in--between, along with other nationalities (14.0 +/- 1.40). Menarche proved to appear earlier in girls from very well-to-do families (13.95 +/- 1.36) than in those from families with a very low income (14.19 +/- 1.43). The latest beginning of the menstruation has been recorded in girls from peasant families (14.38 +/- 1.17). Sporadic repeated investigations of this king in different parts of the country, by using a more modern "status quo" method, appear necessary in order to determine differences in the menarcheal age in the country as a whole and to shed more ligh on their underlying causes.

Adolescent↗
PubMed1976

Chromosome changes in patients treated with "Myleran".

The aim of this study is the determination of chromosomal changes in patients suffering from chronic leucosis, after therapy with the cytostatic "Myleran", to find out whether this cytostatic causes them, because of clinical experience which indicates its value in the treatment of chronic myeloid leukemia. Patients were treated with therapeutic doses of 4 mg per os daily. Analysis with present methods in patients receiving relatively small total doses did not discover the other visible chromosomal aberrations in leucocytes in peripheral blood, except the usual aberrations caused by chronic leucosis.

Busulfan↗
PubMed1975

Colpocystography in cases of genital prolapse and urinary stress incontinence in women.

Experience with colpocystography used routinely in 586 cases of genital prolapse and urinary stress incontinence is described. Radiologic aspects are discussed and related to clinical findings by means of an original classification. The technique is described in detail. Systematic opacification of the urethra permits the study of changes in the urethrovaginal region. Contrary to prevailing opinion, the lower urinary system and the anterior vaginal wall do not participate concomitantly in the process of prolapse but sliding bladder prolapse, which may cause urinary stress incontinence, is often seen. Colpocystography is simple, easy, inexpensive, and safe. Its use in surgical gynecology assits in evaluation the tactical and technical indications, assessing the effectiveness of the operation, and studying recurrences and postoperative complications.

Barium Sulfate↗
PubMedDate not supplied

[Results of an inquiry on stress urinary incontinence in women].

The authors present the results of an inquiry into urinary stress incontinence in 415 women chosen at random, in whom the genital prolapse or stress incontinence were not complaints for hospitalization. The analysis also excluded all states of pregnancy or puerperium. As in other statistics, the frequency of urinary stress incontinence proved very high (39.2%). It is particularly interesting that 52.8% of the women questioned considered it as a completely normal event. A progressive increase in the frequency of stress incontinence related to aging. Stress incontinence was also twice as frequent in manual workers and housewives as in office workers, school girls, and students. In relation to obstetric traumatism, the disease is more frequent in parous women, showing a progressive increase with parity and the delivery of higher-weight newborns, whereas, quite unexpectedly, it proved rare in women with deliveries in intervals shorter than three years. A high incidence was recorded of stress incontinence having appeared in pregnancy for the first time (23.9%); in 59.0% of these women it persisted also after childbirth, which is very significant. Although the trouble is more frequent in menopausal patients, the effect of this period can hardly be separated from the effects related to senile involution. Besides emphasizing the role of the gynecologist, urologist, and general practitioner in the diagnosis of urinary stress incontinence in women, the data obtained raise the question of the revision of the existing views on the physiology of this disorder.

Adult↗
PubMedDate not supplied

[Tissue polypeptide antigen and tumor trypsin inhibitor in pleural effusions of various etiologies].

In 47 patients with pleural effusions of different etiology concentrations of the tissue polypeptide antigen (TPA) and tumour trypsin inhibitor (TATI) were measured. Malignant disease was found in 24 patients and benign one in 23 patients. In a group of patients with malignant pleural effusion the average concentration of TPA was 3102 U/L and of TATI 76.8 ug/L. In a group of patients with nonmalignant effusion these concentrations of TPA were 2381.8 U/L and of TATI 28.3 ug/L. Higher concentration of TPA was found in pleural effusion of malignant nature with specificity of 96% but with a small sensitivity of 12.5% and positive predictive value of 43%. TATI concentrations were also higher in malignant pleural effusion with good sensitivity and specificity (78%, 50% respectively) and positive predictive value of 66%.

Adult↗
PubMedDate not supplied

[Clinical evaluation of serum elastase-1 levels in patients with acute pancreatitis].

The prospective examination and quantitative determination of concentration of serum elastase 1 using RIA method were performed in 75 patients with pancreatic diseases at the Clinic of General and Vascular Surgery and the Institute of Nuclear Medicine of the M.M.A. in the period 1988-1989. The values of serum elastase 1 concentration were compared with values of amylase in serum and urine. The greater diagnostical importance of serum elastase 1 was found compared to values of amylase in serum and urine, not only in patients with acute pancreatitis but also in exacerbation of chronic pancreatitis. The level of serum elastase 1 concentration enables more reliable follow up of the evolution of the disease and therapeutical effects in patients with acute pancreatitis.

Acute Disease↗
PubMedDate not supplied

[Incidence of painful menstruation in Macedonia].

A total of 6930 pupils born between 1955 and 1966 were inquired by a questionnaire. It has been found that painful menstruation was present in 2786 pupils (40.20%) Along with a high percentage of painful menstruations, a high percentage of menstrual disturbances was recorded in younger pupils. Certain differences were found among the nationalities and also in relation to pupils from towns and villages.

Adolescent↗
PubMedDate not supplied

[A full-term abdominal pregnancy. (A case report)].

A case of mature ectopic abdominal pregnancy diagnosed preoperatively by ultrasound is described. Up to the establishment of the diagnosis the case was treated as a normal pregnancy. The foetus died 3 weeks before the term of delivery. The patient was discharged in a good condition 25 days after operation.

Adult↗
PubMedDate not supplied

[Pathogenesis of urinary stress incontinence and principles of its surgical treatment].

As in different types of stress incontinence the mechanism of the destroyed urethral support is not the same, the principles of their surgical treatment are bound to differ. Generally speaking, the surgical intervention in stress incontinence aims at securing adequate mobility of the lower urinary organs, forming an effective suburethral support, and correcting the elements of the prolapse. Applying these principles in 508 women with stress incontinence having been surgically treated at the University Hospital Department of Gynecology and Obstetrics in Skopje from 1968 to 1976 and followed up at least two years afterwards, the global rate of relapses was 6.1%, by which the best results were obtained by Burch's modified method (2.1%), while after operations after Bonney or Barnett the frequency of relapses was relatively higher (7.1%). Analysing technical details in the carrying out of the above mentioned procedures, the authors plead for a most adequate preoperative preparation of patients, so as to determine and categorize the type of stress incontinence in question and allow the choice of the most appropriate surgical intervention in any given case.

Female↗