Search PubMed⌕ Search

Biomedical subjects

A Lavergne

Publications and source records attributed to A Lavergne.

88 records · Page 5Linked to original sources
PubMed1982

Retrograde coronary sinus perfusion: a safe alternative for ensuring cardioplegic delivery in aortic valve surgery.

During aortic valve surgery, cardioplegic solution is delivered through direct cannulation of both coronary ostia. Since this approach may cause an intimal injury leading to acute dissection or late ostial stenosis, we have evaluated retrograde coronary sinus perfusion (RCSP) as a means of delivering cardioplegia in 12 patients undergoing aortic valve replacement. The retroperfusion of the cardioplegic solution was performed with a balloon-tipped catheter inserted into the coronary sinus through the right atrium. The perfusion pressure averaged 40 mm Hg. Twelve patients undergoing antegrade coronary perfusion served as controls. Both groups were matched for preoperative and intraoperative data. The postoperative evaluation focused on hemodynamic status, as evidenced by serial measurements of right-sided pressures and cardiac output at 1, 6, 12, 18, and 24 hours after operation. The stroke volume index and the left ventricular and right ventricular systolic stroke work indexes were then calculated. There was no statistically significant difference between the two groups. We conclude that RCSP is a simple, safe, and effective means of cardioplegic protection during aortic valve surgery.

Adult↗
PubMed1982

[Visceral histologic lesions of lethal acute colchicine poisoning. Apropos of 12 cases].

The authors reported histological characteristics (on post-mortem examination) of 12 cases of lethal acute colchicine intoxication and compare these results with the 5 previous anatomical studies of such cases in the literature. Abnormal mitosis (stathmocinesis, "caryomerie", caryorrhexis and mitonecrosis) are constant and essentially seen in the bone marrow and digestive mucosae, especially in oesophagus which squamous epithelium is more resistant to autolysis than others digestive mucosae. Biological or histological symptoms or lesions of intravascular diffuse coagulation are present 7 cases but both biological and histological manifestations in only one case. Hematological disorders are constant when more than 0.5 mg/kg (of corporeal weight) of colchicine has been ingested. Granulocytic elements are most affected both by hypoplasia (essentially in the first four days) and maturation troubles. A microvacuolar non systematized and diffuse liver fatty change is found in 10 cases, probably related to alteration of lipoproteins synthesis and secretion by hepatocytes. Interstitial myocardial oedema is a constant feature; in addition true interstitial myocarditis (with infiltration by polymorphs) is seen in two cases. These cardiac lesions may be related to the cardiogenic shock which is often observed in these patients.

Acute Disease↗
PubMed1981

Structural and ultrastructural peritoneal membrane changes and permeability alterations during continuous ambulatory peritoneal dialysis.

Normal and abnormal structure of the peritoneum is described in biopsies obtained from 15 cadavers and 13 patients on continuous ambulatory peritoneal dialysis (CAPD) at the onset of their treatment and after several months. In a few patients a loss of ultrafiltration due to a higher permeability of the peritoneum for glucose was observed. This hyperpermeability seems to be due to a patchy or total destruction of the mesothelium; it seems also to be dependent upon the thickness of the fibrous band separating capillaries from the peritoneal cavity. The endothelium of capillaries was normal in all the specimens examined.

Cell Membrane Permeability↗
PubMed1980

[Lipid levels of epithelial cells and parathyroid activity. Preliminary study of 30 patients].

During surgical cervical exploration of 30 patients with hyperparathyroidism (primary or secondary) 67 specimens have been collected: 22 adenomas, 2 glands of primary hyperplasia and 28 glands of secondary hyperplasia (in 7 patients). Fat content of parenchymal cells has been studied using Oil Red O stain on cryostat cut sections: this content is very low in hyperactive lands (adenomas, primary or secondary hyperplasias) and high in normal or suppressed glands, even enlarged. There is no correlation between parenchymal fat and stromal fat. Practical and theoretical implications of these results are discussed.

Adenoma↗
PubMedDate not supplied

Effect of peroperative hypertension on 125I-albumin uptake by vein graft media.

Aortocoronary bypass, in use for over 20 years, is followed by lesions in 80% of vein grafts after 10 years. In 8 patients (mean age 60, SD = 7.8) before cardiopulmonary bypass, segments of saphenous vein were harvested, and following hydraulic distension (760 mmHg x 10 min), stripped of adventitia, de-endothelialized, cannulated, immersed in oxygenated Krebs solution pH 7.4 37 deg C, and pressurized (100 mmHg) with 4% 125I-albumin-Evans blue for two hours. The samples were then frozen, and serially sectioned in the plane of the lumenal surface. The radioactivity of the 20 microns-thick sections was then determined, and expressed as a tissue: labelled solution concentration ratio (cpm unit volume wet tissue/cpm unit volume labelled solution). Distended portions had a higher mean transmural concentration ratio, as compared with the undistended portion; the ratio distended/undistended was 1.23, SD = 0.17, n = 8, p less than 0.01 (paired t test). This suggests alteration in the transport properties of vein interstitium by hypertension. Random histologic examination of native veins revealed no structural damage apart from age-related dystrophy of elastic fibres and intimal and medial fibrosis in grossly normal veins. These results suggest that the quality of the vein used, combined with hypertension during its preparation, may be factors in the genesis of postoperative graft failure.

Aged↗
PubMedDate not supplied

[Oxyurid granuloma of the mesentery].

A 44-year-old woman presented with an acute abdominal syndrome associated with fever. Laparotomy revealed a mesenteric mass; pathology demonstrated a granuloma containing an adult threadworm (Enterobius vermicularis) and its eggs. Ectopic oxyuriasis is rare, and only three cases of peritoneal granuloma distant from the pelvis or the appendix have been reported previously. Our observation is the first case to which a clinical symptomatology could be ascribed. The pathogenesis and the treatment of this particular localization of oxyuriasis are discussed.

Adult↗
PubMedDate not supplied

[Digestive localization of generalized amyloidosis: attempt of differentiation of "primary" and "secondary" amyloidosis (author's transl)].

The aim of this study is to precise topography of amyloid deposits in the alimentary tract and to differenciate the primary or secondary nature of amyloid substance according to these topographical data and with the help of the Wright's technic. The material of this study consists in nine necropsies and seventeen digestive biopsies, concerning patients with generalized amyloidosis. Immunoglobulinic amyloidoses (so-called "primary") contain predominating deposits in the muscularis propria which remain after Wright's technic. On the other hand, in the non-immunoglobulinic amyloidoses (so-called "secondary"), deposits are essentially localized in the mucosa and disappear (more than 80%) after Wright's technic. Moreover, some special cases, as Portugese amyloidosis and amyloidosis in the course of Crohn's disease, are studied. In the first case, the immunoglobulinic nature of amyloidosis seems to be very likely. In Crohn's disease, in one case, the classical notion of non-immunoglobulinic amyloidosis is confirmed, while, in another one, the amyloidosis is much likely an immunoglobulinic one, and that is a new fact. The authors insist on the practical aspect of this study: it is usually possible to precise the nature of the amyloid deposit on digestive biopsy and so, to give indications to the clinicians about an etiological group.

Amyloidosis↗