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Biomedical subjects

A Lassus

Publications and source records attributed to A Lassus.

At least 127 records · Page 7Linked to original sources
PubMed1976

HLA antigens in psoriasis. A family study.

HLA antigens were determined in 14 Finnish families with psoriatic members. The pedigrees of all families are presented. The results showed a clear association between HLA B13 and inheritable psoriasis, for all the 14 HLA analysed psoriatic patients in four families had B13. In one family all five psoriatic patients had the haplotype HLA-A10, Bw17; in two other families the association between Bw17 and psoriasis was less obvious. In three families six of the eight children with the haplotype A1, Bw37 had psoriasis. In all these families one parent had psoriasis or psoriatic relatives and the other parent contributed A1, Bw37. It is suggested that Bw37, in association with other genetic factors, indicates a high risk of developing psoriasis. In one family both the father with psoriatic arthritis and the son with post-urethritic Reiter's disease had A2, B27. This haplotype was also possibly associated with psoriatic arthritis in two families.

ABO Blood-Group System↗
PubMed1976

Psoriatic arthritis and Reiter's disease. HLA antigens in mixed cases.

HLA antigens were determined in 25 Finnish patients with both Reiter's disease and skin lesions identical with psoriasis vulgaris. HLA B27 was found in 23 cases (92%) B13 was found in one case, Bw17 and Bw37 were not found at all. The absence of these three "psoriatic" HLA antigens in the present series indicates that the psoriasis-like skin lesions belong to the varying clinical picture of Reiter's disease and not to the HLA linked psoriasis vulgaris.

ABO Blood-Group System↗
PubMed1975

The deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus. I. Clinical evaluation.

A clinical evaluation of the intradermal DNA-test was carried out on a series of patients with untreated or with treated definite systemic lupus erythematosus (SLE), or with suspected SLE with or without circulating antinuclear factors. A saline solution of a commercially available DNA-preparation was used. The course of the DNA reaction was followed for 24-48 h after the injection. All nine cases of untreated definite SLE had a positive DNA test 6 h after the injection, and eight cases a positive result at 24 h. All seven patients with definite SLE who were on low-dosage systemic steroid treatment had a clinically positive. DNA test at 6 h. In all except one of these cases the test was still positive at 24 h. All five patients with definite SLE on antimalarial treatment had a positive test at 6 h which had become negative at 24 h after the injection. Eleven of the twelve patients with suspected SLE and circulating antinuclear factors had a positive DNA test at 6 h, which in nine cases persisted for 24 h. On the other hand, of the eleven ANF negative patients with various connective tissue diseases five had a positive test at 6 h. In only one of these cases it persisted for 24 h. Two of the eighteen control patients with various dermatoses exhibited a positive test at 6 h, and in one of these the positive reaction persisted for 24 h. It is concluded that the intradermal skin test using native DNA is a useful diagnostic tool for the detection of SLE when the reaction is followed up for 24 h. Antimalarial treatment seems to decrease skin reactivity to native DNA.

Adrenal Cortex Hormones↗
PubMed1975

The deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus. 2. Histological findings.

A total of fifty-five biopsies from fifty-two intradermal DNA skin tests were studied. The biopsies were taken, 6, 8-10, 24 or 48 h after the injection of the DNA material. Necrosis of the vessel wall was taken to be the main characteristic of a specific reaction. In forty of the fifty-two tests the results of the histological evaluation closely matched the clinical results. In five of the fifteen cases with discrepancies, the histological evaluation ruled out clinically false positive test results. In three cases of SLE on corticosteroid treatment, the histological examination gave a positive result despite a clinically negative result. In seven of the fifteen cases the discrepancies occurred in borderline cases with reactions of 5 to 6 mm diameter. The amount of inflammatory cells in positive as well as in negative reactions was also recorded. The number of polymorphonuclear cells in positive reactions increased with the age of the reaction. The number of lymphocytes was not found to increase in the positive reactions, thus differing from the delayed hypersensitivity type of reactions. Rather, the reaction was characterized by an Arthus type of hypersensitivity. On the basis of the present study it may be concluded that clinically positive tests at 6 or 8 h may merely be expressions of nonspecific vascular alterations. On the other hand, in late reactions, even in patients on systemic treatment, histological examination revealed clinically negative results to be positive. By using the histological picture of hypersensitivity angiitis as the main diagnostic criterion the specificity of the clinical reactions may be established.

Adult↗
PubMed1975

Psoriatic lesion of the sternal synchondrosis.

Radiography of the synchondrosis between the manubrium and the sternal body was performed in 29 patients with clinically certain psoriatic arthropathy. Tomography proved necessary for a detailed analysis. Erosive inflammatory lesions were detected in 18 cases; in 61 per cent of cases with a history of more than 5 years and in 71 per cent of cases with typical hand and feet arthropathy. It is concluded that the sternum is frequently involved in cases with roentgenologically typical psoriatic arthropathy.

Adult↗
PubMed1975

HL-A antigens in patients with persistent palmoplantar pustulosis and pustular psoriasis.

HL-A typing was performed in a series of 22 patients with persistent palmoplantar pustulosis, 14 patients with palmoplantar pustulosis and psoriasis, 15 patients with generalized pustular psoriasis and 45 patients with uncomplicated psoriasis. None of the patients with persistent palmoplantar pustulosis alone had relatives with psoriasis, which was a common finding in the other groups. The HL-A antigens 13 and 17 were markedly increased in the group of uncomplicated psoriasis. In the group of patients with persistent palmoplantar pustulosis alone neither of these antigens was increased, as compared with a control population. Four patients with persistent palmoplantar pustulosis and psoriasis had HL-A 17 or 13 and two patients with generalized pustular psoriasis had HL-A 17. In the latter group HL-A 27 occurred in eight cases and correlated with the presence of sacro-iliitis. It was concluded that persistent palmoplantar pustulosis is an entity genetically distinct from psoriasis even if psoriatic patients might have an increased tendency to develop this type of pustular reaction.

Dermatitis↗
PubMed1975

Circinate erosive balanitis and HL-A 27.

The HL-A phenotype of 17 patients with a typical clinical picture of circinate erosive balanitis was determined. Eight of the patients had other signs of Reiter's disease and 9 had balanitis alone. HL-A 27 was found to be present in 15 of the 17 cases. One patient of each group lacked this antigen. The frequency of the other histocompatibility antigens did not significantly differ from that of a Finnish control population.

Adolescent↗