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Biomedical subjects

A Lassus

Publications and source records attributed to A Lassus.

At least 91 records · Page 5Linked to original sources
PubMed1981

Local treatment of acne. A clinical study and evaluation of the effect of different concentrations of benzoyl peroxide gel.

A total of 50 patients with moderately severe acne was treated with either 3%, 5% or 10% benzoyl peroxide gel for 4 weeks. Forty-eight patients maintained the treatment for the whole trial period while in 2 cases treatment has to be discontinued because of severe irritation of the treated skin areas. In all the remaining cases a definite remission of the acne activity could be observed at the end of the 4-weeks' trial. In some cases the gel had to changed to a stronger or a milder concentration during the trial either because of insufficient effectiveness or irritation.

Acne Vulgaris↗
PubMed1980

Ocular inflammation in Reiter's disease after Salmonella enteritis.

We studied characteristics of ocular inflammation in Reiter's disease after Salmonella enteritis in eight patients. After an acute onset with diarrhea, fever in six patients, and headache in three patients, all patients developed arthritis; six patients had myalgia; six patients, urethritis; and one patient, carditis. Sacroiliitis was found in four patients. All patients had HLA-B28 antigen. Conjunctivitis occurred in seven patients. It was mostly mild with no chemosis, follicles, or keratitis, and resolved in ten days. In one case palpebral edema, chemosis in the conjunctiva, and purulent exudate were seen. One patient had transient episodes of keratitis and corneal erosion for two months and episodes of conjunctivitis for 11 months. Three patients developed unilateral acute anterior uveitis with aqueous flare, cells, fine keratic precipitates, and fibrinous exudation from three to four years after the onset of the illness. One of these patients had vitritis and macular and papillary edema.

Adolescent↗
PubMed1980

Psoriasis and HLA-Cw6.

The prevalence of histocompatibility antigen HLA-Cw6 was 72.7% in twenty-two patients with the guttate form and 45.9% in thirty-seven patients with the vulgaris form of psoriasis; the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors in Finland is highly significant. The previously observed excess of several HLA-B locus genes might be secondary to their close linkage with the Cw6 gene. Hereditary factors appear more important in the guttate than in the vulgaris form of psoriasis.

Finland↗
PubMed1980

Systemic treatment of psoriasis with an oral retinoic acid derivative (Ro 10-9359).

Ninety-seven patients with severe psoriasis took part in a 1-year study to evaluate the effect of a new oral synthetic retinoid (Ro 10-9359). The trial was performed in a double-blind cross-over fashion. The treatment started with either 100 mg daily of Ro10-9359 or placebo and the maintenance dose was in most cases 50 mg. Follow-up examinations were performed monthly and the parameters erythema, desquamation, infiltration and extent of the lesions were followed. Throughout the study there was a significant to highly significant preference for Ro 10-9359 shown by all parameters. More patients were in complete remission after Ro 10-9359 periods than after placebo periods. The side-effects of Ro 10-9359 on uninvolved skin and mucous membranes seemed to be largely dose-dependent. Twenty-three patients interrupted the study, four of them because of side-effects, mainly alopecia. Laboratory examinations revealed no aberrations which could be attributed to the therapy. One patient developed hepatitis during a placebo period.

Adult↗
PubMed1980

Treatment of psoriasis and atopic dermatitis with halcinonide cream applied once and three times daily.

In a double-blind multi-centre study, comprising ninety-five patients with psoriasis and atopic dermatitis, 0.1% halcinonide cream applied once daily was equally as effective as the cream applied three times daily. However, the onset of action was more rapid when the cream was applied three times daily. In a control study once daily application of 0.1% halcinonide cream was found to be superior to the vehicle alone in the treatment of forty patients with the same diseases.

Administration, Topical↗
PubMed1980

Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo. A double-blind partner-controlled study.

The effect of sulphadiazine and trimethoprim (T-S) was compared with that of a placebo in the treatment of 75 men with nongonococcal urethritis (NGU) and their female sexual partners. Forty (53%) men and 30 (40%) women had positive culture results for Chlamydia trachomatis before treatment was started. Thirty-four patients of each sex received active treatment. Of these, 19 men and 15 women had positive culture results for C trachomatis before treatment with T-S and one of each sex had a positive culture result after treatment. C trachomatis had been isolated in 21 men and 15 women before treatment with placebo. At follow up four weeks after treatment had been started, 16 men and 15 women still harboured C trachomatis. Five of the chlamydia-positive patients treated with placebo developed complications (epididymitis, arthritis, or salpingitis) so the trial was discontinued.

Chlamydia Infections↗
PubMed1980

PUVA treatment for alopecia areata.

41 patients with severe alopecia areata were treated with either local or oral 8-methoxypsoralen and UVA irradiations. In 26 cases (73%) a good to excellent result was obtained. The number of irradiations required for regrowth varied but 20--40 treatments were sufficient in most cases with a positive response. Patients with circumscribed or ophiasic alopecia responded better than patients with total or universal alopecia, atopy or a family history of alopecia did not seem to influence the outcome of the treatment. The age of onset of the disease seemed to be of importance as well as the duration of the treated attack. Patients over 20 years at the first attack of alopecia showed a better response than patients with an earlier onset of the disease. During a follow-up period of 6--12 months of 20 successfully treated patients only 2 had a recurrence.

Adolescent↗
PubMed1980

Treatment of pityriasis rubra pilaris with an oral aromatic retinoid (RO 10--9359).

A patient with widespread PRP was first treated with an oral aromatic retinoid (RO 10--9359) and PUVA in successive periods. Retinoid treatment resulted in marked improvement but during PUVA treatment the disease became re-activated. The patient was finally treated with aromatic retinoid alone, which brought the disease to remission in 6 weeks.

Administration, Oral↗
PubMed1979

Theoretical considerations on HLA-associated illness-susceptibility genes in dermatitis herpetiformis and psoriasis.

The frequency of an HLA-associated illness-susceptibility (Is) gene can be estimated by a simple equation: the frequency of the Is gene is equal to the prevalence of the disease in the population divided by the penetrance of the illness in first-degree relatives with the HLA marker antigen, with the quotient further divided by two. This equation is valid if the gene is dominant and its gene frequency is low. An analysis of HLA data of 61 patients with dermatitis herpetiformis (DH) showed that the HLA-associated DH susceptibility gene is obviously dominant. The frequency of this DH susceptibility gene was estimated to be at least 0.0005 and the frequency of psoriasis susceptibility gene about 0.02 in Finland.

Dermatitis Herpetiformis↗
PubMed1979

Short-term treatment of gonorrhoea with intramuscular and oral forms of trimethoprim-sulphamethoxazole.

Fifty-nine male patients and 41 female patients with uncomplicated gonorrhoea were treated with an intramuscular dose of 1600 mg sulphamethoxazole plus 320 mg trimethoprim followed by an oral dose of 2400 mg sulphamethoxazole plus 480 mg trimethoprim 12 hours later. Forty-nine out of 52 male patients and 37 out of 38 female patients who were re-examined were cured. One of the men probably had a reinfection.

Administration, Oral↗
PubMed1979

Mezlocillin in the treatment of gonorrhoea.

A single, intramuscular dose of 2 g of mezlocillin was used for the treatment of 158 patients with gonorrhoea. In only three out of 144 patients with urogential gonorrhoea who were re-examined did the treatment fail. Of 12 patients with pharyngeal gonorrhoea who were examined after treatment 10 were treated successfully with the same dose. The sensitivities of the gonococci to mezlocillin and penicillin G correlated well, although mezlocillin seemed to be active at lower concentrations on both highly sensitive and less sensitive isolates.

Female↗
PubMed1979

Clobetasone butyrate and hydrocortisone butyrate in the treatment of eczema: a double-blind comparison.

Forty patients with symmetrical eczematous lesions on their extremities were treated in a double-blind fashion with 0.05% clobetasone butyrate and 0.1% hydrocortisone butyrate in cream bases. After 2 weeks of treatment, a preference for clobetasone butyrate was observed in 7 cases, for hydrocortisone butyrate in 9 cases and in 24 cases both sides responded equally. The lesions on both sides improved steadily throughout the study in all cases. When completing the trial after 2-weeks' treatment, the clobetasone butyrate-treated lesions had healed in 8 cases and the hydrocortisone butyrate-treated lesions in 10 cases. No local side-effects were observed.

Administration, Topical↗