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Biomedical subjects

A Langlands

Publications and source records attributed to A Langlands.

30 records · Page 2Linked to original sources

"Doctor, what are my chances"?

There can be no more difficult consultation than one in which the clinician has to explain a diagnosis of cancer and provide information on likely outcomes. The considerable skills in communication that are necessary are not usually part of medical training and the generalisations of the textbooks are of little value.

Communication↗

Bone metastases in hypernephroma. Frequency of scapular involvement.

A consecutive series of 95 patients with hypernephroma was studied retrospectively after it was clinically suspected that there was a propensity for this tumor to metastasize to the scapula. Fifteen patients (15.8%) have developed scapular metastases which account for 36.6% of all bone metastases in this series, the majority of which required radiotherapy for pain relief. The scapula was a solitary site of bone metastasis in the majority of patients, and, even when associated with other bone lesions, was frequently an isolated site of pain. A comparative series of 40 consecutive patients with breast cancer metastatic to bone was retrospectively studied. Twenty-five percent of these showed scapular metastases but these were all in association with multiple (greater than 3) other bone metastases; none was symptomatic or required treatment. There was a suggestion that hypernephromas spread more often to the ipsilateral scapula, but the trend did not reach statistical significance. Scapular metastasis in hypernephroma is a common and clinically significant problem, sometimes giving a clue to the primary site. The cause for this predilection is not known.

Adult↗

Natural history of breast cancer.

Retrospective analysis was made of 3,918 cases of breast cancer seen during 1954-1964. Median survival was 4.5 years and 30% of patients survived through a 10-year period. For stages I, II, and III patients, the mortality increased during 1-4 years after diagnosis and then slowly declined. Beyond 15 years, stage III patients assumed the same mortality (5%) as those with lesser disease; 58% excess of deaths from all causes after 15-20 years showed that breast cancer was not curable within 20 years but ultimately, taking account of clinical status, 51% of 5-year survivors with stages I-III disease are cured.

Breast Neoplasms↗

Promoting the Health of the Nation.

This article outlines the opportunities that the NHS has to contribute to the Government's health strategy The Health of the Nation, launched in 1992. The article also gives an overview of progress made towards achieving primary Health of the Nation targets.

Forecasting↗