[Analgesia by intra-cerebro-ventricular injection of morphine in cancer pain: clinical and pharmacokinetic studies].
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Adult↗
Biomedical subjects
A Langlade
Publications and source records attributed to A Langlade.
[Role of thermal neurolysis in the treatment of cancer pain of the face].
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Electrocoagulation↗
[Evaluation and assessment of pain in the acutely painful patient: methodological problems].
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Acute Disease↗
Local increases of subcutaneous beta-endorphin immunoactivity at the site of thermal injury.
To examine interactions between exogenous opioid analgesia and endogenous opioid generation at a site of burn-induced tissue injury, we measured beta-endorphin (BE) and corticosterone (C) in aliquots of plasma and wound fluid withdrawn from subcutaneous wire mesh chambers beneath the site of a 3-5% surface area burn. After brief inhalational anesthesia at the time of thermal injury, rats received morphine (4 mg/kg, single dose), fentanyl (0.02 mg/kg hourly for 4 h), or no opioid. Systemic hormone responses and behavioral changes were minimal as expected for the minimal percentage burn. In all three groups intrachamber BE and C rose above baseline at 1, 2 and 4 h postburn, then returned to baseline at 24 h. Systemic opioid treatment produced analgesia (by tail flick latency testing) but did not reduce intrachamber hormone responses. Thus local BE and C responses at the site of thermal injury are regulated differently from systemic pituitary-adrenal responses.
Analgesics, Opioid↗