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Biomedical subjects

A Langaney

Publications and source records attributed to A Langaney.

33 records · Page 2Linked to original sources
PubMed1984

Genetic study of Tunisian Berbers. I. Gm, Am and Km immunoglobulin allotypes and ABO blood groups.

The Gm, Am and Km immunoglobulin allotypes and ABO blood groups were studied in three groups of Tunisian Berbers . The results showed that the actual Berbers of Tunisia present certain heterogeneity and their ancestors were probably the first inhabitants of North Africa. Indeed, although their Gm-Am haplotypes are mainly Caucasoid, some of them are typically African. The group of Kesra village, the most Caucasoid, shows frequencies of Gm-Am haplotypes very close to those of South European populations, particularly the Spanish, who are probably of the same origin. The gene frequencies of the ABO groups in the three Berber groups were similar to those recorded in European populations with a relatively high frequency of the O genes typical of the Berbers .

ABO Blood-Group System↗
PubMed1980

Frequencies of Gm and Km allotypes in the population of Singapore, Sri Lanka and Punjabis in North India.

Serum samples from Sinhalese subjects, from Punjab and from Singapore have been studied. The Gm phenotypes found are very numerous and we can observe some similarities concerning the Gm gene frequencies between the Singapore Indians with the Indians of North India, and with the Sinhalese. In contrast, Gm gene frequencies found among Chinese and Malays from Singapore are quite different from those found among Indians of Singapore. Our results here are very similar to those obtained in Malaya studies.

China↗
PubMed1979

[Measles and temporary increase in masculine births: coincidence or causality?].

Data from three West-African populations shows significant increase of sex-ratio. In two of them a considerable excess of male births came from conceptions the year following an epidemic of measles. This is limited to the villages affected by this epidemic. These facts seem to be similar to those related to hepatitis and sex-ratio. They suggest similarities between measles virus and surface antigens of Y sperms. This hypothesis could be tested by immunological investigation.

Antigens, Surface↗
PubMed1979

Gm, Am and Km immunoglobulin allotypes of two populations in Tunisia.

Gm, Am and Km allotypes were investigated in two Tunisian populations (236 samples from Mahdia and 142 samples from Sfax). These populations descend from immigrants and, therefore, the results were compared with those obtained in other populations living in the Near East and in North Africa. The subclass heavy chain allotypes G1m, G2m, G3m and A2m are inherited in fixed combinations. There were five main and four minor Gm-Am haplotypes that could be deduced from the phenotypes. This led to the conclusion that the populations studied are Caucasoids with some African admixture (about 10%) and a very low oriental contribution. Furthermore, there were 11 samples which showed 8 uncommon Gm-Am phenotypes. These could be explained by the assumption of five different uncommon Gm-Am haplotypes. Four of these may have arisen by equal crossing over of prevalent haplotypes. The fifth may be the result of unequal crossing over of prevalent haplotypes. The fifth may be the result of unequal crossing over, since it was proven, by family study, that more markers are transmitted together than are present in the prevalent haplotypes.

Female↗
PubMed1975

Comparative study of haemoglobin types of two populations of eastern Senegal--Bedik and Niokholonko.

The haemoglobin types of 1487 of the East Senegal Bedik and Niokholonko populations have been studied. There are significant differences between them, the most likely explanation of which is that the populations are of different origins. The Bedik appear to be the most ancient known settlers in East Senegal: they possess only A and S haemoglobins. The Niolholonko came later, probably from Mali: they have a lower frequency of S genes but AC and AD phenotypes are also encountered among them.

Anemia, Sickle Cell↗
PubMed1975

Gm and Inv allotypes in French Guiana Indians.

Data from 302 individuals belonging to three populations of French Guiana Indians are reported. All the phenotypes except two can be explained by three haplotypes: Gm1,21, Gm1,2,21 and Gm1,10,11,25. The gene frequencies found in the present study are generally in accordance with those previously described among other South American Indians. For the Inv1,2 gene a high value has been found for the Wayanas and the Oyampis, but a difference appears for the Emerillons who possess a low frequency.

Blood Group Antigens↗
PubMed1975

Gm and Inv allotypes in a Gypsy sample.

Serum samples from 226 Gypsies were tested for Gm(1,2,4,5,8,10,11,14,17,21,23,25) and for Inv(1,2). The Gm phenotypes found are very numerous and the more frequent among this population are: Gm(4,5, 8,10,11,14,17,23,25) and Gm(1,2,4,5,8,10,11,14,17,21,23,25). All the phenotypes except three can be explained by nine haplotypes: Gm4,5,8,10,11,14,23,25, Gm1,4,5,8,10,11,14,23,25, Gm4,5,8,10,11,14,25, Gm1,17,21, Gm1,10,11,17,25, Gm1,2,17,21, Gm1,8,17,21, Gm1,8,17,21,23 and Gm1,5,10,11,14,17. The haplotypes Gm1,17,21, Gm1,2,17,21, Gm4,5,8,10,11,14,25 (with or without Gm[ 3]) are all three common among Caucasoids, Gm1,4,5,10,11,14,23,25 (common among Mongoloids) and Gm1,5,10,11,14,17 (common to Negroids). For the Inv system, this population possesses a very low frequency of Inv(1) and Inv(2).

Ethnicity↗
PubMedDate not supplied

[Mitochondrial DNA polymorphism reveals a genetic differentiation between ethnic groups in the population of Jerba].

Jerba is an island situated in the South-East of Tunisia were some ethnic groups (Arabs, Berbers, Blacks, Jewishs and others) cohabit for centuries. The religion and cultural differences have represented an obstacle to a mixture between these groups. In order to evaluate the genetic differentiation between the muslim groups (Arabs, Berbers and Blacks), we have analysed the polymorphism of a mitochondrial DNA coding region. The cytochrome oxydase coding region (COII) was amplified by PCR in 57 Arabs, 42 Berbers and 16 Blacks. The amplified products were analysed by Restriction Fragment Length Polymorphism (RFLP). Genetic distances were calculated by using the AMOVA program. The values of these distances were significantly different between Arabs and Blacks, and between Berbers and Blacks but not between Arabs and Berbers. So That, to refine the evaluation of genetic diversity between Arabs and Berbers, we have analysed the polymorphism of a second mitochondrial coding region which encodes for the fifth unit of NADH deshydrogenase (ND5). Eleven haplotypes were defined from the resulting data of mitochondrial COII and ND5 polymorphism and a significant genetic distance between Arabs and Berbers was computed.

Analysis of Variance↗