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Biomedical subjects

A Lahti

Publications and source records attributed to A Lahti.

At least 91 records · Page 5Linked to original sources
PubMed1980

Allergy to birch pollen and apple, and cross-reactivity of the allergens studied with the RAST.

Apple-pulp allergens are unstable, but fresh material can be used for skin testing. In this study stable allergens, probably of a protein nature, were extracted from apple seed and used in radioallergosorbent tests (RAST). Apple-seed allergens were shown by RAST inhibition to cross-react with birch pollen allergen(s). Cross-reactivity may explain the frequent co-occurrence of birch pollen and apple allergy. Approximately 50% of patients in a group with immediate hypersensitivity to birch pollen were also sensitive to apple as judged by a history of symptoms, skin tests with apple-pulp and apple-seed preparations, and apple-seed RAST.

Adolescent↗
PubMed1980

Extraction and properties of apple allergens.

It is shown that apple allergens are probably proteins and that they can be extracted in an active form only if reactions with phenolic compounds present in apple are inhibited. This is accomplished by incorporating chelators and solid polyvinylpolypyrrolidone in the extraction medium. Phenol, commonly used as a preservative, should not be added. With the RAST, serum-IgE antibodies capable of reacting with apple allergens were detected in 90% of patients with clinical apple allergy, in 44% of patients with clinical birch-pollen allergy and in 5-10% of patients with other atopic allergies. RAST inhibition indicated that apple and birch-pollen allergens cross-react.

Allergens↗
PubMed1980

Immediate contact allergy to birch leaves and sap.

Fresh sap and crushed leaf of birch (Betula verrucosa) were tested with the scratch chamber method in 117 atopic persons, 74 of whom were allergic and 43 nonallergic to birch pollen, and in 33 control patients. Immediate positive reactions to birch sap were seen in 39% and to leaf in 28% of the patients allergic to birch pollen, in one of the birch pollen-negative patients, but in none of the control patients. Birch leaves may cause contact urticaria in the Finnish sauna, where bath whisks made of birch sprigs are traditionally used.

Dermatitis, Atopic↗
PubMed1978

Hypersensitivity to apple and carrot can be reliably detected with fresh material.

Hypersensitivity to birch pollen was linked with allergy to apple and carrot, apple seeds and carrot seeds and also with their fractions. Skin reactions among other atopics were rare, and non-atopic patients showed no reactions to fresh fruits and vegetables. Apple and carrot as well as apple seeds and carrot seeds were fractionated using column chromatography. Two major fractions were obtained, one with sugar and proteins, and one with proteins, the latter giving skin reactions more often than the former. The correlation between clinical symptoms and skin test results with the fractionated material was somewhat lower than that obtained with the non-fractionated fresh material. The allergens of fruits and vegetables might be proteins (enzymes).

Adolescent↗
PubMed1977

Immediate reactions to fruits and vegetables.

Common fruits and vegetables were tested as such with the "scratch-chamber" method in 388 patients with various atopic disorders. Of the patients with hypersensitivity to birch pollen, 36% showed immediate positive responses to these natural, fresh materials. Apple, carrot, parsnip and potato elicited reactions more often than, e.g. swede, tomato, onion and parsley. On the basis of clinical data, the relevancy of the results of the skin tests was 80-90%. Both "false positive" and "false negative" responses were seen. Itching and tingling with or without oedema of the lips, mouth and tongue were the most common complaints after eating raw fruits and vegetables. In addition, laryngeal and abdominal disturbances, rhinitis and hand dermatitis were recorded. Among patients without allergy to birch pollen, reactions to fruits and vegetables were rare. The nature of the allergens could not be determined.

Adolescent↗
PubMed1976

A rhomboid nose-side flap in nasal skin defects.

A reliable flap method for covering a defect caused by the excision of basal cell carcinoma of the alar region is presented. It is suitable for an out-patient procedure. The flap is elevated from the side of the nose. The design of the flap is as follows: its caudal margin coincides with the cephalad margin of the lesion; the medial side of the flap is drawn parallel to the dorsum of the nose; the cephalad side runs back at an acute angle to the lower lid below the eye, incorporating a part of the lower lid and cheek tissue in the flap. Twenty basal cell carcinomas have been treated at the Department of Dermatology, Helsinki University Central Hospital between 1973--1975 using the flap with good cosmetic results. This flap is a useful alternative to the naso-labial flap in a Finnish nose.

Basal Cell Carcinoma↗