[Dosimetry of colloidal radiogold by means of neutron activation analysis with a low power reactor].
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Biomedical subjects
Publications and source records attributed to A Laconi.
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The histochemical behaviour of alkaline phosphatase, adenosintriphosphatase, acid phosphatase and acetylglucosaminidase activities was studied in rat kidney treated with Chloromeridrin Hg. In these experimental conditions it was found that the nephrocytes in the proximal convoluted tubule present changes in the enzymatic activities examined, generally proportional to the doses employed. With lower doses of radionuclides, the histoenzymatic changes have a local character and are completely reversible after a month. With higher doses they take on a more extensive character and persis to some extent one month after treatment. These findings suggesti that Hg could be used clinically with due precautions.
Experiments on the biologic effects of ultrasound (US) were carried out on rat embryos exposed for 120 s to a US beam showing features similar to those already employed for diagnostic purposes. Electron microscopic investigation of the liver parenchyma of rat embryos confirmed results obtained from adult guinea pigs with the same duration of exposure, i.e. diffuse vacuolization of cytoplasma and varying degrees of mitochondrial damage.
Within the limits of a systematic research on the biological effects of the ultrasounds, the authors refer on their personal experience on rat's embrions treated, for 120 seconds, with a ultrasonic beam having the common characteristics used in diagnostic investigations. The ultra-structural studies on the hepatic parenchyma substantially confirm the previous results obtained in the adult cavy, exposed for the same period of time, i.e. a diffuse cytoplasmic vacuolization and an unstable mitochondrial damage. Various suggestions are advanced on the particular sensibility that the mitocondria show because of the ultrasonic action. The authors explain the limits of their experimentation in this specific sector of the scientific research.
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