Biomedical subjects

A L Weber

Publications and source records attributed to A L Weber.

At least 127 records · Page 7Linked to original sources

PubMed1977

Computed tomography of the skull and facial structures: preliminary evaluation of direct coronal sections.

Skull and facial structures may be evaluated on computed tomography (CT), as well as the brain. A valuable new dimension to the study has been added with the feasibility of obtaining direct coronal sections using a wide gantry aperture. The patho-anatomical details of bone and soft tissues including the orbit and paranasal sinuses are well demonstrated. Direct viewing on a display console of an enlarged quadrant of the scan is of prime importance in diagnosing fine changes involving the thin facial bones.

Humans↗

PubMed1975

Aminoacyl transfer from an adenylate anhydride to polyribonucleotides.

Imidazole catalysis of phenylalanyl transfer from phenylalanine adenylate anhydride to the hydroxyl groups of homopolyribonucleotides was investigated as a chemical model of the biochemical aminoacylation of tRNA. Imidazole catalyzed transfer of phenylalanine to poly(U) increases from pH 6.5 to 7.7 and decreases above pH 7.7. At pH 7.7 approximately 10% of the phenylalanyl residues are transferred to poly(U). At pH 7.1, transfer to poly(U) was five times as great as to poly(A) and transfer to a poly(A) poly(U) double helix was negligible. At pH 7.1 approximately 45 mole percent linkages to poly(U) were monomeric phenylalanine; the remainder of the linkages were peptides of phenylalanine. The number of linkages and their lability to base and neutral hydroxylamine indicates that phenylalanine and its peptides are attached as esters to the 2' hydroxyl groups throughout poly(U) and the 2' (3') hydroxyl groups at the terminus of poly(U). These results do model the contemporary process of aminoacyl transfer to tRNA and continue to suggest that a histidine residue is in the active site of aminoacyl-tRNA-synthetases.

Adenosine Monophosphate↗

PubMed1975

Congenital asymmetry (hemihypertrophy) and abdominal disease: radiological features in 9 cases.

Coexistent abdominal disease was found in 9 cases of congenital asymmetry. These patients appear to be at risk of malignant neoplasms of the adrenal gland, kidney, and liver. Five of the 6 neoplasms in this group of patients were malignant. Approximately 25% of the reported cases of hemihypertrophy have been associated with hamartomas or congenital defects, especially genitourinary anomalies. Benign disorders encountered in this group included medullary sponge kidney, renal ectopia, renal cyst, nephromegaly, adrenomegaly, and hypospadius.

Abdomen↗

PubMed1974