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Biomedical subjects

A L Thomas

Publications and source records attributed to A L Thomas.

At least 73 records · Page 4Linked to original sources
PubMed1978

Changes in the fetal thyroid axis after induction of premature parturition by low dose continuous intravascular cortisol infusion to the fetal sheep at 130 days of gestation.

The effect of cortisol infusion on plasma T4 and T3 concentrations has been investigated in the fetal lamb at 130-134 days of gestation. Infusion of cortisol at rates equivalent to one-third the quantity produced by the fetus at the time of parturition results in a significant fall in fetal plasma T4 concentration and a significant rise in fetal plasma T3 concentration. Delay in the initiation of labor as a result of progesterone administration to the ewe did not prevent the changes in the fetal thyroid axis. These modifications of thyroid function therefore appear to be caused by the infusion of cortisol rather than to be secondary to the induction of labor.

Animals↗
PubMed1976

Talampicillin: a new derivative of ampicillin.

Talampicillin is a thiazolide carboxylic ester of ampicillin and is hydrolysed in the intestinal mucosa to release free ampicillin. The mean peak serum concentration of ampicillin occurred one hour after a dose of talampicillin and was about twice that attained by an equivalent dose of ampicillin. The presence of food in the stomach reduced and delayed the peak blood levels but did not affect the total amount of antibiotic absorbed or the urinary recovery. Talampicillin had less effect on the faecal flora in volunteers than ampicillin, and no overgrowth with Candida spp or Staphylococcus aureus was seen. Thirty-eight out of 47 urinary infections were eradicated by a seven-day course of talampicillin.

Adsorption↗
PubMed1975

Ultrastructural changes in the placenta of the ewe following foetal infusion of cortisol.

The placental changes which followed continuous infusion of cortisol into the sheep foetus in the later stages of gestation were, like the hormonal changes, broadly similar to those of spontaneous parturition. There was, however, a premature separation of foetal and maternal tissues in certain areas of the placental cotyledons, and this separation appeared to protect the foetal epithelium from the degenerative changes which normally take place in the short space of time between the birth of the lamb and the delivery of the foetal membranes. The results suggest that an experimental model in which premature labour is induced by the administration of cortisol to the foetus is probably incomplete, and that additional factors almost certainly contribute to the cascade phenomenon of spontaneous parturition.

Animals↗
PubMed1975

Effect of synthetic thyrotrophin releasing hormone on thyrotrophin and prolactin concentractions in the peripheral plasma of the pregnant ewe, lamb fetus and neonatal lamb.

Synthetic thyrotrophin releasing hormone (TRH) has been administered to pregnant ewes, chronically catheterised fetuses in the latter stages of gestation, and to newborn lambs. Both the pregnant ewe and her fetus showed marked rises in TSH and prolactin concentrations after administration of TRH. The placenta was impermeable to TRH, TSH and prolactin in both directions. The sheep fetus near term and the newborn lamb both demonstrated a considerable reserve of secretory capacity for TSH and prolactin.

Animals↗
PubMed1974

Comparison between sequelae of surgical and medical treatment of venous thromboembolism.

Thirty-six patients have been studied clinically and phlebographically three years after a major deep vein thrombosis. Twenty were treated surgically and 16 medically. The incidence of post-thrombotic symptoms was similar in the two groups. The use of superficial femoral vein ligation to prevent embolism will not worsen the prognosis of a leg which is already the site of deep vein thrombosis.

Adult↗