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Biomedical subjects

A L Robin

Publications and source records attributed to A L Robin.

101 records · Page 6Linked to original sources
PubMed1983

Histologic characteristics of filtering blebs in glaucomatous eyes.

Tissues from six functioning and four failed filtering blebs in glaucomatous eyes examined by light and electron microscopy showed normal epithelium. The response of the subepithelial connective tissue differed in the two groups. Failed blebs had dense collagenous connective tissue in their walls. In functioning blebs, the subepithelial connective tissue was loosely arranged and contained histologically clear spaces. These clear spaces corresponded in size and position to microcystic spaces seen clinically in functioning blebs. The presence of microcystic spaces visible by slit-lamp examination is probably a good sign of bleb function.

Conjunctiva↗
PubMed1983

The effect of argon laser trabeculoplasty on the medical control of primary open-angle glaucoma.

Argon laser trabeculoplasty was performed in 33 eyes with primary open-angle glaucoma whose intraocular pressures were poorly controlled on medical therapy. Five eyes (three patients) were failures and underwent trabeculectomy within three months. The remaining 28 eyes were followed up for 18 months and received a complete examination at periodic intervals. Beginning three months after trabeculoplasty, an attempt was made to decrease medications in a prospective manner in order to determine the least treatment required to maintain a pressure of less than 22 mmHg. No medication could be discontinued in 39% of eyes, whereas 18% were "cured" by trabeculoplasty and required no further medical therapy for control. Nine of 14 eyes that had been treated with carbonic anhydrase inhibitors were controlled without these drugs after trabeculoplasty. In 57% of eyes, the miotic could be discontinued. A total of 82% of cases still required some medication for pressure control after laser trabeculoplasty.

Adult↗
PubMed1982

Argon laser peripheral iridotomies in the treatment of primary angle closure glaucoma. Long-term follow-up.

We analyzed the long-term results after argon laser peripheral iridotomy in 98 eyes of 54 patients with primary angle closure glaucoma. During a mean follow-up period of about five years, visual acuity, intraocular pressure, medication changes, and the need for filtration surgery or cataract surgery were used to evaluate the amount of possible damage that had resulted from laser iridotomy. Eyes treated with the argon laser did not appear to differ significantly from those of similar patients, described in other series, in which surgical iridectomy had been used as the therapy of choice. Argon laser peripheral iridotomy appears to be a laser peripheral iridotomy appears to be a safe and effective means of treating primary angle closure glaucoma.

Adult↗
PubMed1982

Histologic studies of angle structures after laser iridotomy in primates.

Each of nine eyes of five cynomolgus monkeys had argon laser peripheral iridotomies performed to investigate the histologic effects on the trabecular meshwork. The laser technique was the same as is used in human eyes. With laser iridotomy, particulate debris was released into the anterior chamber and rapidly accumulated in the angle. The densest initial deposit was in the inferior juxtacanalicular trabecular meshwork. Histologically, pigment was located both extracellularly and within giant vacuoles of the endothelium and Schlemm's canal and intracellularly within trabecular endothelial cells. This finding indicates that this pigment is removed from the anterior chamber both by bulk aqueous flow and by phagocytosis. One year after iridotomy, only a slightly increased pigmentation of the angle was still present. No permanent ultrastructural damage to the angle was detected.

Animals↗
PubMed1982

Corneal endothelial changes after argon-laser iridotomy and panretinal photocoagulation.

We performed argon-laser peripheral iridotomies on the right eyes of eight cynomolgus monkeys and administered panretinal scatter photocoagulation to the left eyes of the same monkeys. Both eyes of each monkey were photographed and studied with a slit lamp, pachymetry, and direct and indirect specular microscopy. After follow-up periods of 0 to 31 days, the monkeys were killed and the enucleated eyes studied by light and scanning electron microscopy. Scanning microscopy were deposits showed that the changes observed by specular microscopy were deposits on the endothelium. Only minimal damage occurred and there were no significant changes in endothelial cell density after either treatment.

Animals↗
PubMed1982

Argon laser trabeculoplasty: its effect on medical control of open-angle glaucoma.

Twenty persons with primary open-angle glaucoma (POAG) were followed for an average of one year in a prospective study after argon laser trabeculoplasty was performed in one eye. By one month the mean intraocular pressure (IOP) had fallen 39% and was associated with an 80% increase in mean facility of aqueous outflow. Eighteen persons with POAG were evaluated for the possibility of maintaining an IOP of less than 22 mm Hg with less medication than was required prior to laser treatment. One third of these patients required no medication after treatment, and 39% required less; however, 28% of persons who were poorly controlled before treatment required the same regimen to maintain control after laser trabeculoplasty. Six out of nine persons no longer required a carbonic anhydrase inhibitor while six out of eight persons no longer required a miotic. Laser trabeculoplasty failed to produce a sufficiently large fall in IOP in most persons on maximal medication to permit discontinuation of all medication; but it produced its most satisfying response in persons whose glaucoma was less difficult to control.

Carbonic Anhydrase Inhibitors↗
PubMed1979

Transient reversible cupping in juvenile-onset glaucoma.

A 17-year-old man had marked glaucomatous cupping of his left optic nerve. Two days after trabeculectomy, the appearance of the disk changed dramatically, appearing full, rather than cupped. Over the next month, with normal intraocular pressure, the optic nerve resumed its preoperative excavated appearance.

Adolescent↗
PubMed1979

An analysis of visual acuity, visual fields, and disk cupping in childhood glaucoma.

We analyzed the long-term functional results in 102 eyes of 59 patients with childhood glaucoma with specific reference to the pattern of optic nerve damage. Optic disk photography and quantitative perimetry were used to judge the degree of damage that had been sustained. There was a predilection for initial visual field damage in the arcuate area, followed by further arcuate and nasal field loss, similar to the pattern of visual field loss seen in adult glaucoma. In children, as in adults, neural tissue appeared to be lost preferentially at the vertical disk poles. The selective pattern of glaucomatous optic nerve damage seemed not to depend upon the age of the optic nerve structures. In contrast to adult eyes, the scleral canal in children apparently enlarges with high IOP. Thus, disk cup size increase in children could occur from neural tissue loss, from scleral canal enlargement, or from a combination of the two processes.

Adolescent↗
PubMed1977

Recurrence of macular corneal dystrophy after lamellar keratoplasty.

A 20-year-old man required bilateral lamellar keratoplasties for macular corneal dystrophy. Histochemical proof of macular corneal dystrophy was demonstrated in both of the excised lamellar corneal buttons. Eleven years later, the patient underwent a penetrating kiratoplasty in his left eye. Light microscopic, histochemical, and electron microscopic study of the excised button disclosed characteristic features of macular corneal dystrophy in the donor cornea. Recurrence of macular corneal dystrophy in a corneal graft appeared to be the result of replacement of the donor keratocytes by genetically defective host cells.

Adult↗