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Biomedical subjects

A L Hudson

Publications and source records attributed to A L Hudson.

65 records · Page 4Linked to original sources
PubMed1979

Synthesis and biological activities of [7-(azetidine-2-carboxylic acid)]-oxytocin and -lysine-vasopressin.

[7-(Azetidine-2-carboxylic acid)]-oxytocin and -lysine-vasopressin have been synthesised by a (6 + 3) strategy using protected hexapeptide acids with preformed disulphide bridges, and their biological activities have been investigated. All activities were reduced but not to the same extent. In assays of pressor and antidiuretic activity it was observed consistently that the responses to the vasopressin analogue were of shorter duration than responses to lysine-vasopressin of the same amplitude.

Amino Acid Sequence↗
PubMed1978

Isoguvacine, isonipecotic acid, muscimol and N-methyl isoguvacine on the GABA receptor in rat sympathetic ganglia.

The GABA-mimetic activities of 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine have been examined at the GABA receptor in the rat isolated superior cervical ganglion. The depolarizing action of all 4 analogues could be selectively antagonized by bicuculline methochloride and isopropyl bicyclophosphate. Muscimol was the only analogue more potent than GABA (molar potency ratio = 5.08 +/- 0.707). The potency of isoguvacine was 0.23 +/- 0.026 and isonipecotic acid 0.011 +/- 0.0028. N-methyl isoguvacine was less than 0.001 GABA.

Animals↗
PubMedDate not supplied

Social interactions, perceived support, and level of distress in HIV-positive women.

Although powerful pharmacological therapies are helping women with HIV infection live longer, women continue to experience the stressors of chronic illness. This study used a person-environment systems framework to describe social interactions, perceived social support, and psychological distress in HIV-positive women. A convenience sample of 104 HIV-positive women living in the San Francisco Bay Area completed a questionnaire on social interactions, perceived social support, and distress. Women reported limited social interactions with family and friends and a low level of perceived social support. Social support and level of distress did not differ by ethnicity. Limited perceived social support was a significant predictor of distress in this sample of women. Supportive interactions from health care providers can be useful in mediating the relationship between the stressor of HIV disease and distress in HIV-positive women. Community-based nurses can enhance HIV-positive women's support network by providing positive and supportive interactions as they intervene with women in symptom management, case management, and other health care services.

Adult↗
PubMedDate not supplied

Perceptions of social support of African Americans with acquired immunodeficiency syndrome.

Using the grounded theory methodology with symbolic interactionism as the theoretical framework, this study explores the perceptions of support systems that exist for African Americans with AIDS. A convenience sample of five African Americans with AIDS was interviewed and the data analyzed using constant comparative analysis. Seven themes emerged: (a) independence and control over one's environment, (b) support from significant others, (c) keeping a positive attitude, (d) spirituality, (e) lack of family support, (f) appreciation for case management, and (g) avoidance of support groups. The analyses and conclusion derived from these themes have many implications for nursing, the most important being the need for education preparation of professional nurses as case managers.

Acquired Immunodeficiency Syndrome↗