"Stress" and lipids.
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Coronary Artery Disease↗
Biomedical subjects
A L Edwards
Publications and source records attributed to A L Edwards.
Social desirability and Wiggin's MMPI content scales.
Using the Minnesota Multiphasic Personality Inventory (MMPI) item pool, Wiggins (1966) developed 13 scales, each with a homogeneous content. The 13 scales, along with marker scales for the 1st 3 MMPI factors, Edward's social desirability (SD), Welsh's repression (R), and Wiggins's social desirability (Sd) respectively were scored in the MMPI. The same scales were scored in an Experimental Multiphasic Personality Inventory (EMPI). A principal-components analysis of the 16 scales when scored in the MMPI resulted in 4 factors. A principal-components analysis of these same scales when scored in the MMPI and when scored in the EMPI were found to be highly congruent. The SD, R, and Sd scales proved to be excellent markers for the 1st 3 factors of the MMPI and also for the 1st 3 factors of the EMPI. Results provide further evidence that the 1st MMPI factor is a social desirability factor rather than a content factor.
Adult↗
Factors affecting patency of venous allografts in miniature swine.
In immunologically defined National Institutes of Health miniswine, a segment of internal jugular vein was anastomosed to the carotid artery as an interposition graft. Patency of swine major histocompatibility complex matched, one haplotype mismatched, and complete mismatched veins was 9.8, 6.3, and 3.0 weeks respectively (p = 0.009). More than 90% of mismatched and 20% of matched allografts developed a positive crossmatch before occlusion (p = 0.006). The mixed lymphocyte response did not predict graft occlusion. Treatment of 10 swine with cyclosporine (10 mg/kg/day) did not significantly improve patency for one haplotype mismatched grafts. In haplotype mismatched veins, cryopreserved grafts occluded more rapidly than noncryopreserved grafts: mean 2.4 versus 6.3 weeks, respectively (p = 0.002). In all cryopreserved vein grafts, alloantibody appeared at or after graft occlusion rather than before occlusion as seen with fresh allografts (p = 0.046). The mean patency of cryopreserved versus fresh autografts was 3.3 and greater than 32 weeks, respectively (p = 0.004). In summary, these results indicate that (1) allograft patency is related to the degree of swine major histocompatibility complex match and development of cytotoxic alloantibodies; (2) moderate-dose cyclosporine does not prolong allograft patency nor suppress development of antibody; (3) cryopreservation may accelerate graft occlusion through nonimmunologic mechanisms.
Animals↗
Testicular function in hyperthyroidism.
Testicular function was assessed in nine men aged 17 to 35 years and seven men aged 36 to 46 years with Graves' disease. Levels of total testosterone, estradiol, sex hormone binding globulin, luteinizing hormone, and follicle stimulating hormone, and gonadotropin responses to gonadotropin releasing hormone were significantly greater than these levels and responses in age-matched controls. Although the percentage of free testosterone was lower than control values in the hyperthyroid men, calculated levels of free testosterone were not different from normal. Lower than normal percentages of free estradiol values resulted in higher than normal calculated free estradiol levels. As a result, the free testosterone/free estradiol ratio in the men with Graves' disease was lower than normal. Although mean sperm densities in the hyperthyroid men were not different from control values, the percent forward progressive motility of sperm from these men was significantly lower than control values. The hormonal and seminal abnormalities corrected when the patients became euthyroid after radioiodine therapy. The results of this study indicate that hyperthyroid men may have abnormalities in their hypothalamic-pituitary-testicular axes.
Adolescent↗