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Biomedical subjects

A L Dourmishev

Publications and source records attributed to A L Dourmishev.

14 recordsLinked to original sources
PubMed2001

Inflammatory linear verrucous epidermal nevus.

Inflammatory linear verrucous epidermal nevus (ILVEN) is an unusual unilateral eruption with onset usually in infancy or childhood, female predominance, frequent left leg involvement, pruritus, refractoriness to therapy, and a psoriasiform histologic pattern. We review this disorder in describing a 5-year-old girl who also had melanodontia, an association not previously observed to our knowledge.

Carcinoma, Verrucous↗
PubMed1999

Dermatomyositis and drugs.

Dermatomyositis (DM) is an idiopathic inflammatory disorder consisting of skin and skeletal muscle involvement. Patients with skeletal muscle involvement have polymyositis (PM), and those unresponsive to therapy and with characteristic findings on muscle biopsy have inclusion body myositis. Patients without muscle damage and typical skin lesions have amyopathic dermatomyositis. Disease in children (juvenile dermatomyositis) is not associated with malignancy as it may be in adults (paraneoplastic dermatomyositis). Overlap syndrome (OS) is mixed connective tissue disease combining some features of DM, SS and LES. Scleromyositis is overlap syndrome associated with anti-PM-Sci antibodies. Patients with PM, DM or OS with "interstitial lung disease" and anti-synthetase antibodies have an "anti-synthetase syndrome". Various drugs, including d-penicillamine, NSAIDs, anti-infectious agents, as well as lipid lowering drugs, the HMG-CoA reductase inhibitors may cause myopathy and skin lesions (drug induced dermatomyositis). "Dermatomyositis" occurring as adverse reactions of drugs are rare, irregular and impossible to predict in individual patients. They are very interesting in that they may be keys for explaining the pathogenic mechanisms of the disease.

Dermatomyositis↗
PubMed1998

Crusted scabies of the scalp in dermatomyositis patients: three cases treated with oral ivermectin.

BACKGROUND: Cutaneous features in the scalp area among adult patients are rarely considered as a manifestation of scabies. METHODS: Three patients with clinical and laboratory data of dermatomyositis with scalp involvement (fulfill three or four of Bohan and Peter's criteria), of 4 years, 8 months, and 3 years duration, were seen at our department between 1995 and 1996. For relapses of ordinary scabies, they were treated repeatedly with local scabicide with temporary effect. After a symptom-free period during the treatment of dermatomyositis with corticosteroids and azathioprine, they developed diffuse redness with scales and crusts on the scalp areas. Light microscopy examination of material taken from these crusts showed an abundance of live mites. RESULTS: All patients were successfully cured of scabies with a twice oral dose of 200 microg/kg ivermectin within 8 days. CONCLUSIONS: Our patients with crusted scabies of the scalp and dermatomyositis prompted us to change our standard diagnostic and therapeutic regimens. Fascinating features included mimicry of scabies in patients with dermatomyositis, location of parasites on the scalp, suppressed cell-mediated immunity and successful cure of mange by ivermectin.

Adult↗
PubMed1996

Pyoderma gangrenosum in childhood.

Pyoderma gangrenosum is an uncommon cutaneous disorder that often begins as a small pustule, but results in localized skin destruction. The latter is characterized by an expanding ulceration with undermined violaceous borders. It may be due to an altered immune response. It often, but not invariably, reflects underlying systemic disease.

Child↗
PubMed1984

Anti-DNA antibodies in blood serum of psoriatic patients.

The anti-DNA antibody titer (heat denatured, native and monostranded) was studied in 61 patients with psoriasis and 41 healthy controls. Positive titers of anti-DNA antibodies were established in 19.3% of the psoriatics and in 4.9% of the controls. Antibodies against heat-denatured DNA were discovered in 8.2% of the patients and in 0% of the healthy persons; against native DNA in 18% of the psoriatics and 4.9% of the controls and against monostranded DNA in 31.7% of the psoriasis patients and 9.8% of the control group. In general, the percentage of the positive titers of anti-DNA antibodies in psoriatics was about 4 times higher than that of the healthy controls.

Adult↗
PubMed1984

Free fatty acids in the blood serum of psoriatics.

Free fatty acids in the serum of 60 patients with generalized psoriasis were studied by a gas-chromatographic method. The same investigations in 40 healthy persons served for control purposes. It was established with statistical probability (p less than 0.001) that in the serum of psoriatics the levels of palmitic (C 16: 0), stearic (C 18: 0), arachidic (C 20: 0), and docosadienic (C 20: 2) acids were increased, while the levels of the linoleic (C 18: 2) and arachidonic (C 20: 4) acids were depressed. There is no behenic acid (C 22: 0) in the blood serum of psoriatics. Thalassotherapy caused no significant changes in the levels of these free fatty acids in psoriatics.

Adult↗
PubMed1983

HLA system and therapy of psoriasis.

In 192 patients with psoriasis an increased frequency of the antigens HLA-B13 (19.79%, X2 = 32.79, p less than 0.001), HLA-B17 (24.47%, X2 = 64,84, p less than 0.001), and HLA-B27 (19.27%, X2 = 11.07, p less than 0.001) in comparison with the control group of 1,085 clinically healthy persons, was established. After 4 weeks of thalassotherapy 3 groups of patients could be distinguished: (1) those with full clinical remission - 50 (26.8%), (2) those with great or moderate improvement - 116 (60.4%), and (3) those with no improvement - 26 patients (13.6%). In the first two groups there is a statistically significant association with the HLA antigens B13 and B17. In the third group (no improvement) there is no such association with HLA-B13 (p less than 0.01). Consequently, patients in whom psoriasis is associated with HLA-B13 were better influenced by the thalassotherapy. The variability in the therapeutic efficiency means that perhaps there is a genetic heterogenicity in the group of common psoriasis.

Adolescent↗