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Biomedical subjects

A L Delaunois

Publications and source records attributed to A L Delaunois.

At least 19 recordsLinked to original sources
PubMed1979

Spectrum analysis of the EEG in schizophrenic patients.

A method is presented for the harmonic analysis of the human EEG. Its use for the study of schizophrenic patients under phenothiazine treatment is discussed and some examples are given. Correlations are observed with clinical evolution and plasma level of the drugs.

Antipsychotic Agents↗
PubMed1978

Neuromuscular blocking agents and spontaneous sympathetic activity.

The action of neuromuscular blocking agents on the spontaneous sympathetic activity has been quantitated. "On line" spectrum analysis has been applied to the action potential of pre- and post ganglionic nerves of the coeliac plexus. The activity, the frequency spectrum and their changes after the injection of clinical and high doses of decamethonium, D-tubocurarine, succinylcholine, gallamine and pancuronium are determined.

Action Potentials↗
PubMed1978

Spectrum analysis of transient phenomena of the left ventricular pressure.

The application of "real time" spectrum analysis to left ventricular pressure during transient phenomena is described. Transient phenomena generated by the injection of drugs (norepinephrine-isoproterenol), anoxia and occlusion of aorta and carotids show sudden changes in the frequency of heart contraction. Propranolol stabilizes the heart rate in similar circumstances.

Animals↗
PubMed1978

Distinct muscarinic mediation of suspected dopaminergic activity in sympathetic ganglions.

The competitive neuromuscular blocking agents, gallamine and pancuronium, enhanced the nictitating membrane contraction, in the cat, resulting from muscarine ganglionic transmission. Inhibition of ganglionic muscarinic hyperpolarization, in response to short tetanic bouts of preganglionic cervical sympathetic stimulation, was an associated event and is considered by us to be causally related. The neuroleptic drug, haloperidol, enhanced ganglionic hyperpolarization under similar stimulatory conditions, and reduced the nictitating membrane contraction elicited via ganglionic muscarine pathways, effects opposite to those produced by the skeletal muscle relaxants. Apomorphine reduced both ganglionic hyperpolarization and the ganglionic muscarinic-induced nictitating membrane contractions. The action of gallamine and pancuronium conforms to a speculative cholinergic antagonism at the specific muscarinic receptors, termed Mi, on the ganglionic dopaminergic interneuron. Haloperiodol and apomorphine are anticipated to be exerting distinct antagonistic and agonistic actions, respectively, on prejunctional dopamine receptors of the ganglionic interneuron. Ganglionic slow depolarization mediated through the muscarinic receptors, termed Me, was unaltered by any of the agents studied.

Animals↗