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Biomedical subjects

A L Bhatia

Publications and source records attributed to A L Bhatia.

30 records · Page 2Linked to original sources
PubMed1982

Tritium toxicity in mouse testis: effect of continuous exposure during pre- and postnatal development.

Pregnant mice were continuously irradiated (5 micro Ci/ml of drinking HTO; 0.9 rd/day) from the 16th day post coitum. Quantitative and qualitative studies were made on testis of mice 3, 4 and 5 weeks post partum. Testes showed various histopathological lesions like cytoplasmic vacuolation, exfoliation, giant cell formation, denudation, haemorrhage, hyperaemia and sclerosis. Three weeks old mouse testis was found histopathologically more damaged. The population of spermatogonia types A, intermediate and B were maintained at approximately 80%, 70% and 60% of the controls respectively; while that of spermatocytes was maintained at roughly 70%. The population of spermatids at 4 and 5 weeks was approximately 45%.

Animals↗
PubMed1979

Crypt cell population kinetics in mouse jejunum under continuous beta irradiation from tritiated water.

The behaviour of crypt cell population in mouse jejunum under continuous beta irradiation from tritiated water (HTO) has been studied. Adult mice were maintained on tritiated drinking water of the activity of 1.25 muCi/ml, after priming injection. The crypts were studied at 1, 5, 7, 15 and 30 days after the initiation of treatment. It is observed that there is a partial recovery in proliferative activity after the first day of the treatment. Again there is a decrease in the crypt cells on the 7th day, after which this population appears to achieve a near-steady-state level at about 8% below normal at the last interval studied. Crypt cell population and mitotic figures showed a simultaneous dip and recovery, while dead cells showed inverse relationship.

Animals↗