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Biomedical subjects

A L Aronson

Publications and source records attributed to A L Aronson.

57 records · Page 4Linked to original sources

The automatic external defibrillator-pacemaker: clinical rationale and engineering design.

Prompt defibrillation is the cornerstone of therapy for out-of-hospital sudden cardiac arrest. Overwhelming evidence indicates that victims whose cardiac arrest is witnessed and whose ECG rhythm is ventricular fibrillation can be successfully resuscitated, with significant prolongation of life. The automatic external defibrillator-pacemaker (AEDP) is designed to be used by family members of patients with known heart disease, by basic level technicians in emergency rescue systems, and by lay rescuers in corporate-industrial-public environments. The AEDP is designed for safety and ease of use. It incorporates a highly sensitive and specific electronic diagnostic logic. It defibrillates and paces with a unique tongue-chest electrode system or through two adhesive chest electrodes. The AEDP should be a cost-effective device for the treatment of sudden cardiac arrest and can play a major role in public health strategies for optimizing care for this enormous problem.

Biomedical Engineering↗

Simultaneous multiresidue analysis of beta-lactam antibiotics in bovine milk by liquid chromatography with ultraviolet detection and confirmation by electrospray mass spectrometry.

A multiresidue analytical method was developed for the simultaneous determination of amoxicillin, cephapirin, procaine penicillin G, ampicillin, cloxacillin, and ceftiofur in bovine milk. The method involved ultrafiltration of milk diluted with an equal volume of 50% acetonitrile through a 10,000 dalton molecular mass cutoff filter. Separation of these beta-lactam antibiotics from other milk components was performed by ion-paired (octane- and dodecanesulfonate) liquid chromatography using a phenyl column eluted with acetonitrile-water solution. Ultraviolet absorbance of the column effluent was monitored in the 200-350 nm range of a photodiode-array detector. For quantitation, the chromatograms were acquired at lambda 210 nm for penicillin G, ampicillin, and cloxacillin; lambda 230 nm for amoxicillin; and lambda 290 for cephapirin, procaine, and ceftiofur. The limit of detection for the simultaneous determination of these antibiotics was estimated to be 100 ppb. Liquid chromatography/electrospray mass spectrometry could be used to confirm these antibiotics for quantities down to 100 pg entering the mass spectrometer.

Animals↗