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Biomedical subjects

A L Anduze

Publications and source records attributed to A L Anduze.

9 recordsLinked to original sources
PubMed1999

A new locus for autosomal dominant stargardt-like disease maps to chromosome 4.

Stargardt disease (STGD) is the most common hereditary macular dystrophy and is characterized by decreased central vision, atrophy of the macula and underlying retinal-pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. STGD is most commonly inherited as an autosomal recessive trait, but many families have been described in which features of the disease are transmitted in an autosomal dominant manner. A recessive locus has been identified on chromosome 1p (STGD1), and dominant loci have been mapped to both chromosome 13q (STGD2) and chromosome 6q (STGD3). In this study, we describe a kindred with an autosomal dominant Stargardt-like phenotype. A genomewide search demonstrated linkage to a locus on chromosome 4p, with a maximum LOD score of 5.12 at a recombination fraction of.00, for marker D4S403. Analysis of extended haplotypes localized the disease gene to an approximately 12-cM interval between loci D4S1582 and D4S2397. Therefore, this kindred establishes a new dominant Stargardt-like locus, STGD4.

Chromosome Mapping↗
PubMed1996

Indications for and complications of mitomycin-C in pterygium surgery.

BACKGROUND AND OBJECTIVE: The purposes of this study are to examine the complications and results of a novel approach to the use of mitomycin-C in pterygium surgery; to identify the lowest effective dosage required to prevent recurrence; and to select those high-risk pterygia that could benefit from mitomycin-C use. PATIENTS AND METHODS: One hundred thirty-five eyes of 128 patients considered at high risk for recurrence of pterygium were treated with a single, intraoperative, subconjunctival injection of mitomycin-C at the site of excision. Three different dosages-0.2, 0.1, and 0.05 ml-at a strength of 0.5 mg/ml were used. The eyes were observed for 10 months to 3 years. RESULTS: There were only two recurrences (1.5%); both occurred in eyes that had undergone previous pterygium surgery. One recurrence happened with the 0.2-ml dosage, and the other with the 0.1-ml dosage. These recurrences occurred in association with early wound dehiscence, which essentially became a bare sclera susceptible to pterygium regrowth. Complications included temporary and prolonged discomfort, tearing, hyperemia, subconjunctival hemorrhage, wound dehiscence, and pigment accumulation. No vision-threatening side effects were noted. CONCLUSIONS: The persistence and intensity of discomfort noted at the higher dosage has prompted these authors to suggest that only high-risk pterygia should receive mitomycin-C. Conjunctival flaps should always be used to cover the sclera up to the limbus and to localize the mitomycin-C to prevent its migration. A single dose of not more than 0.05 ml at a strength of 0.5 mg/ml subconjunctivally gives the same results as multiple drops, but with far less morbidity.

Adolescent↗
PubMed1993

Ultraviolet radiation and cataract development in the U.S. Virgin Islands.

Ultraviolet (UV) radiation is one of several factors thought to cause cataracts. This retrospective study of a population in the West Indies who had had voluntary cataract surgery sought to determine the effect of a relatively high level of UV exposure and the type of exposure. This population had a high incidence of nuclear/brunescent cataracts, which correlates with the type of radiation present. Yet the results indicate that although chronic exposure to UV radiation may play a role in the type and location of cataracts, other factors (e.g., age, diabetes) are more important in their formation.

Adult↗
PubMed1989

Merest sclera technique for primary pterygium surgery.

Over a 5-year period, 800 patients with primary pterygium underwent "merest sclera" surgery, a procedure in which the injured limbo-conjunctival area is covered completely with superior and inferior conjunctival flaps so that the tear film can be reestablished. After a 1-year follow-up, 17 recurrences were found (2.1%). All these resulted from premature wound dehiscence and/or postoperative infection.

Conjunctiva↗
PubMed1985

Pterygium: clinical classification and management in Virgin Islands.

Three hundred (300) patients from the Caribbean area and Southeast United States were classified and evaluated for pterygium surgery. Each subject had the surgical excision performed by the same surgeon (ALA). Each was followed for a period of one year postoperatively while receiving topical vasoconstrictors and artificial tears only without steroids, thiotepa, or beta-irradiation. Attempts were made to predict the probability, incidence, and type of recurrence, in relation to specific risk factors identified in each individual preoperatively. Those subjects exposed to highest number risk factors seemed to correlate best with ptergia recurrence. Recurrences, which consisted of pterygium regrowths onto the cornea, were classified as active or passive. Nineteen recurrences occurred in this series, the majority being in the secondary group where more than five risk factors were present. Of 270 eyes classified as primary ptergia that were operated upon by wide excision and suture closure, there were 13 recurrences (5.0%).

Adolescent↗
PubMed1980

Effect of marihuana on intraocular and blood pressure in glaucoma.

Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana. Postural hypotension, tachycardia, palpitations, and alterations in mental status occurred with such frequency as to mitigate against the routine used in the general glaucoma population. Our data indicate that further research should be directed to local means of delivering the ocular hypotensive cannabinoid to the glaucomatous eye.

Adult↗
PubMedDate not supplied

Pterygium surgery with mitomycin-C: ten-year results.

A review of 870 cases of primary and recurrent pterygia done between 1988 and 1998 by the merest sclera conjunctival flap technique with the single application of 0.1 cc of 0.4 mg/mL of mitomycin-C to the subconjunctival space is reported. There were 3 recurrences (0.35%) and no vision threatening complications. The adverse effects were mild and easily resolved with topical treatment.

Antibiotics, Antineoplastic↗