Biomedical subjects
Publications and source records attributed to A Kyriakidis.
Metabolic investigations were made in 21 cystinuric patients. The results showed a low output of urinary phosphorus and an increase of plasma IgG. These findings and the presence of uric acid in the urine, even in normal values, could play an important role in pathogenesis and stone formation, and also in cystinuria.
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The authors report the first results of the use of mercaptopropionyl-glycine (M.P.G.) in the solubilising and preventive treatment of cystine lithiasis. This substance results in the formation of a soluble cystine M.P.G. complex. It increases the solubility of cystine much more than D-penicillinamine. Twenty one cases of cystinuric cystine lithiasis were treated in this way, combined with forced diuresis, alkalinisation of the urine and uricolytic treatment. In 4 of their 21 patients, calculi disappeared completely, whilst in another 3 they decreased in size. Recurrence of lithiasis was avoided in 20 patients out of 21. These impressive results are similar to those in the brief literature concerned with the substance. Toxicity is virtually nil and its efficacy make this the drug par excellence for cystine lithiasis.
The case of a women with a large renal leiomyoma is presented. The patient suffered from pain in the right iliac fossa which led to the detection of a right-sided mobile abdomino-pelvic tumour. This was felt to be an ovarian tumour in torsion but at surgery proved to be a large renal leiomyoma and was treated by partial nephrectomy.
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18 patients with unilateral staghorn calculi managed by selective hypothermic perfusion are presented and the results reported. The procedure proved to be simple, safe and effective in the management of most staghorn calculi.
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