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Biomedical subjects

A Kumar

Publications and source records attributed to A Kumar.

At least 1,729 records · Page 96Linked to original sources
PubMed1988

Male gonads in leprosy--a clinico-pathological study.

Sixty male leprosy patients (mean age 27.2 +/- 5.04 years) selected at random, were studied for gonadal involvement with the mean duration of illness 4.17 +/- 3.27 years. Only lerpomatous and borderline leprosy cases developed testicular and epididymal changes. Testicular pain and/or swelling (lepromatous 62.5%, borderline 30%) was the main presenting feature. Altered sexual function was observed in 34(56.6%) cases, and 11 patients revealed altered sexual hair pattern. Gynecomastia was seen in 9 cases. Reduced testicular size along with its soft feeling was present in 25% of cases while no testicular sensation was felt in 8 (13.3%) cases, and impaired testicular sensation in 9 (15%) of them. Spermogram revealed azoospermia in 19 (35%) and oligospermia in 16 (26.6%) cases. Histo-pathology revealed evidences of leprous pathology irrespective of testicular size, semen picture and clinical manifestations. There was marked variation in histopathological findings in testes and hence it was difficult to categorise them into vascular, interstitial and obliterative phase.

Adolescent↗
PubMed1988

The investigation of unilateral sensori-neural hearing loss.

The site of the lesion in unilateral sensori-neural hearing loss (SNHL) may be confined to the receptor organ (labyrinthine) or may involve the auditory nerve including its central connections (retrolabyrinthine). The primary objective of the investigation of such a loss would be to define the probable site of the lesion. The protocol that we have found most productive and cost effective is as follows: 1. Audiometric evaluation consisting of a well masked pure tone audiogram, speech discrimination score and immitance studies. 2. Vestibular evaluation using photo-electric nystagmography and the Torok Monothermal Differential Caloric Test. Imaging studies of the temporal bone and brain are obtained on the basis of these tests. If the findings from auditory and vestibular tests are equivocal the patient is advised auditory brain stem response (ABR) testing. In our practice serologic tests for syphilis are obtained if there is the slightest suspicion of exposure. In this paper we report 2 cases which illustrate the value of our protocol and reliability of our technique.

Adult↗
PubMed1988

Reverse micelles as a versatile medium for the study of lactate dehydrogenase in vitro.

Rabbit muscle lactate dehydrogenase has been solubilized in cationic reverse micelles of cetyltrimethyl ammonium bromide (CTAB) and isooctane-chloroform (1:1, V/V). The activity of the enzyme was notably affected by the change in water pool, pH, and concentration of the surfactant. Lactate dehydrogenase showed its full activity in this reverse micellar system in non-aqueous solvent under specific conditions at a Wo value of 30.55, pH 7.0, and 100 mM CTAB in comparison to the activity measured in aqueous system under optimum conditions. These results indicate that even the large and complex enzymes (M.W. hundred thousand and four subunits) can be solubilized in apolar solvents where they may retain their conformational integrity and oligomericity, i.e., optimum subunit-subunit interaction with maintenance of full activity.

Animals↗