Biomedical subjects
Publications and source records attributed to A Kuhlwein.
On the basis of medical history and clinical findings of two affected soldiers, we discuss Strandberg syndrome with regard to clinical symptomatology, pathogenesis, hereditary behaviour, differential diagnosis and prognosis. Electron optical as well as histological studies and HLA-type are presented.
The production of vitamin D metabolites in response to ultraviolet irradiation has been studied in 5 control subjects and 8 patients with psoriasis; both groups responded similarly. Significant increases within the normal range were observed for serum 1,25-dihydroxyvitamin D; these increases were negatively related to the initial concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. Serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D increased linearly over the 21 days of study, the production of 25-hydroxyvitamin D being negatively correlated with its own initial concentration. The changes in vitamin D metabolism were accompanied by significant rises within the normal ranges in serum inorganic phosphorus and in urinary calcium. These results indicate the variation of 1,25-dihydroxyvitamin D occurs in vitamin-D-replete adults and that this variation is probably responsible for the observed alterations in calcium and phosphorus metabolism.
Epidermolytic hyperkeratosis is a rare hereditary disease characterized by change of the dermatological signs with advancing age of the patients. At birth as well as during childhood, epidermolysis and blister formation are found; later the general picture of the disease presents horny hystrix-like lesions especially on the flexor parts of the extremities. Bullae become rare in adult life, vulnerability, however, remains. Here we report on 21 patients out of a 38-member family showing the above mentioned clinical findings. Electron-optical as well as histological studies are presented. For the first time HLA-type is reported.
Statistical evaluation of epicutaneous tests performed in 5348 patients during the years 1976 to 1980 revealed positive reactions towards topical steroids in nine cases. Three patients showed an allergy due to Dermoxin (Dermovate). Further tests with the single components of the steroidal cream disclosed a specific hypersensitivity towards clobetasol-17-propionate in two cases, towards the preservative 4-chlor-m-kresol in the third case. Cross-reactions to other fluorinated corticosteroids were not obtained. Experimental sensitisation with clobetasol-17-propionate in guinea pigs remained negative although different methods have been employed.
Erythrokeratodermia congenitalis progressiva symmetrica Gottron (ECPSG) is a rare hereditary disorder characterized by plaques of hyperkeratosis on an erythematous basis. The onset of the disease occurs predominantly in early childhood. Morphological and histological findings give hint for the diagnosis. Ultrastructural findings as well as HLA type (A2, A9, B18) are reported. ECPSG connected with pachyonychia has been observed for the first time.
In an experimental study we examined the influence of a toxic dose of aromatic retinoid (Ro 10-9359) on the spermatogenesis of 30 Wistar rats. Aside from testis tissue of both testes, liver, heart, lung, kidney, adrenal gland as well as the skin have been investigated histologically. The rats received retinoid at a daily rate of 25 mg/kg body weight in physiological salt solution by means of a gastric tube. Another 20 rats receiving only physiological salt solution served as control group. 8 weeks after application of retinoid resp. physiological salt solution, 15 animals with retinoid intoxication as well as 10 control animals were killed. The remaining 25 animals were killed after an application-free interval of 8 weeks. 8 weeks after retinoid intoxication, 6 rats revealed a reduced spermatogenesis, 2 of them with a complete spermatogenic arrest at the stage of spermatocytes I in all analyzed parts of the testes. The diameter of the seminiferous tubules turned out to be decreased by about 30% in comparison to the other 9 rats having received retinoid and to the control group. The spermatogenesis of these 9 rats was equally normal as that of the control group. 8 weeks after withdrawal of the drug there was no sign for reduced spermatogenesis with 14 animals, whereas the 15th rat did not show any cells of spermatogenesis but only Sertoli cells in the seminiferous tubules in all parts of its testes. In liver, heart and lung we observed minimal pathological findings which have to be regarded as an unspecific reaction caused by drug intoxication. All other investigated organs proved histologically no pathological findings.
Clinical, histological and electron microscopical findings of swimming pool granuloma in a 19-year-old soldier are demonstrated. Isolation of Mycobacterium marinum and positive tests with the "Marinum Sensitin" confirmed diagnosis. Problems of treatment are discussed.
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The statistical evaluation of the epicutaneous tests performed between 1976-1980 in the Department of Dermatology at the University Hospital in Hamburg revealed 1320 positive reactions to different contact allergens in 5348 patients (25%). The most frequent responses were found with nickel sulfate. Sixty percent of all positive test reactions were covered by eight of the 30 used allergens ("hit list"). While allergy to tromantidine, arnica and colophony has increased, cases due to methyl salicylate, vioform and turpentine were less frequently seen. Comprehensively, the used standard series has proved to be a representative screening method.
Colophony (rosin) derives from pine resin, tall oil and stump extractives. It is used as is or in chemically modified forms: hydrogenated, disproportionated, esterified, polymerized, as salt or reacted with maleic anhydride or formaldehyde. One of the largest single uses is in the sizing of paper and paperboard. There are hundreds of opportunities for a person to become exposed to colophony and modified products and thus sensitized to it, for example by contact with adhesive tapes, soaps, coating of price labels, eye shadow, periodontal and surgical dressings, furniture polish, glues, musician's rosin, printing inks, printing paper surfaces (newspapers), rubber, plastics etc. The main sensitising components seem to be abietic acid and Abitol (a mixture of different hydroabietyl alcohols). Dermatitis has been described in more than 60 articles; epidemiological studies demonstrate an increasing number of cases since 1980. As wood rosin has been replaced in recent years more and more by tall oil rosin, which is different in its composition, it is recommended to remove the colophony of the standard series (which is derived from pine gum) and to replace it by a mixture of pine, tall oil and stump rosin to diminish the number of probably missed allergic reactions.
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Hydroa vacciniforme Bazin is a rare photodermatosis characterized by bullous skin lesions and distinctive scarring. Early diagnosis is important to provide disfiguring scarring at the light exposed areas of the skin. The onset of the disease occurs predominantly in early childhood and involutes spontaneously at puberty. The case of a 5 years old girl is reported and differentiation from other photodermatoses is discussed.
Investigations in a collective of 73 men sterilized by vasectomy showed, that the preoperative explanations about possible complaints were insufficient. This concerns too in pointing out the necessity of contraception methods after the operation until andrological examination has proved the success of the sterilisation.
A case of infection with Microsporum canis in a German couple which came into contact with cats during holidays in Tunisia is recorded. Atypical clinical features rare localization and the importance of tourism concerning the spread of infections due to Microsporum canis are discussed.
Clinical, histological, and electron microscopical findings helped in to differentiating hyperplasia of a Turkish boy's oral mucosa as Heck's disease, and the hyperplasia of a young German man's oral mucosa as white sponge nevus. Electron microscopic investigations confirmed the presence of papillomavirus in the lesions of FEH.
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