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Biomedical subjects

A Kruse

Publications and source records attributed to A Kruse.

At least 163 records · Page 9Linked to original sources
PubMed1986

Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy.

In a double-blind, randomised trial the efficacy and safety of Ro 15-1788, a new benzodiazepine antagonist, was assessed in forty adults undergoing gastroscopy under diazepam sedation. Criteria of efficacy were the degree of sedation and anterograde amnesia. There was a significantly faster recovery of the patients after the injection of 0.6-1.0 mg of Ro 15-1788 than after placebo. Patients were awake shortly after Ro 15-1788, but remained drowsy or asleep after placebo administration. There were no side effects of note.

Adolescent↗
PubMed1986

Paradoxical response of sphincter of Oddi to intravenous injection of cholecystokinin or ceruletide. Manometric findings and results of treatment in biliary dyskinesia.

Sixty two patients with a clinical suspicion of biliary dyskinesia were investigated with endoscopic manometry of the sphincter of Oddi before and after intravenous injection of cholecystokinin or ceruletide. In 52 patients injection was followed by decreased pressure in the sphincter of Oddi; 43 of these had normal prestimulatory values (group I), while the values were raised in the other nine patients (group II). A paradoxical response to intravenous injection was observed in 10 women (group III): increased baseline sphincteric pressure occurred in eight and increase in the amplitude of phasic contractions in four patients. The prestimulatory sphincteric pressure was raised in five and normal in the remaining patients. Eight patients were treated with papillotomy (seven) or balloon dilatation of the sphincter (one). They experienced relief of pain during a follow up period of 11-16 months. Intravenous injection of cholecystokinin or ceruletide may disclose a special type of biliary dyskinesia even in patients with normal prestimulatory manometric findings. Hormone injection increases the diagnostic yield of endoscopic manometry in patients suspected of biliary dyskinesia.

Adult↗
PubMed1985

Use of a continuous infusion of althesin in neuroanaesthesia. Changes in cerebral blood flow, cerebral metabolism, the EEG and plasma alphaxalone concentration.

Ten patients with small supratentorial tumours were studied during craniotomy. Cerebral blood flow (CBF) was measured in the contralateral hemisphere by a modification of the Kety and Schmidt technique using xenon-133 i.v. With an Althesin infusion rate of 0.2 ml kg-1 h-1, CBF was 24.4 +/- 5.4 ml min-1/100 g and CMRO2 1.87 +/- 0.44 ml min-1/100 g at PaCO2 4.1 +/- 0.7 kPa (mean +/- SD). During constant infusion rates of Althesin, steady values of CMRO2 were obtained, while an increase in infusion rate of 150% was associated with an increase in plasma alphaxalone concentration, a decrease in CMRO2 and a tendency of further EEG suppression. However, great inter- and intraindividual variations were present, and correlations between CMRO2, EEG activity and plasma alphaxalone concentration were weak.

Adult↗
PubMed1985

ERP in chronic pancreatitis--ductal morphology, relation to exocrine function and pain--clinical value.

ERP was analyzed in 87 patients with chronic pancreatitis with special reference to its clinical value in management of pain, the dominating symptom in uncomplicated chronic pancreatitis. A significant correlation was found between ductal changes due to pancreatitis and decrease in pancreatic function. However, no association was found between severe pancreatic pain and pancreatic function or pancreatic morphology. The significance of ERP in management of patients with persistent severe pancreatic pain is discussed.

Adult↗
PubMed1981

Endoscopic sphincterotomy (EST) in patients with Billroth II Gastrectomy.

Methods for endoscopic sphincterotomy (EST) in patients with Billroth-II partial gastrectomy are described. The techniques have been successfully used in 13 out of 18 patients with common bile duct calculi (n = 12) and papillary carcinoma (n = 1). In all patients the calculi were EST. The patient was successfully treated with antibiotics. It is concluded that EST may be performed in most cases with a previous Billroth II operation using differentiated endoscopic techniques.

Aged↗
PubMed1979

Common bile duct and Oddi sphincter pressure before and after endoscopic papillotomy in patients with common bile duct stones.

Pressures in the Oddi sphincter and common bile duct were determined before, immediately after and several weeks after endoscopic papillotomy. Fifteen patients were included in the study. Significant decreases in Oddi sphincter and common bile duct pressures were found and the decrease in Oddi sphincter pressure was to some extent dependent upon the length of the papillotomy.

Adult↗
PubMed1979

Ulcer risk in a duodeno-gastric antireflux operation in dogs.

Duodenogastric reflux is a possible pathogenetic mechanism in some type I gastric ulcers. An antireflux operation is therefore a logical procedure but involves the risk of marginal ulceration. To examine this risk, the following study was performed: 18 dogs were divided into 3 groups of 6. One group had an antireflux operation performed (AR), one had AR plus parietal cell vagotomy (AR + PCV), and the third was a control group that was given daily injections of 40 mg repository histamine. All control dogs developed ulcers after 7-84 days, mean 37 days, of histamine. Three dogs in the AR group developed ulcers spontaneously 55-92 days postoperatively, whereas none of the AR + PCV group developed ulcers spontaneously 72-108 days postoperatively. After histamine injection two of the remaining three AR dogs developed ulcers after 3-4 days of stimulation, and three of the six AR + PCV dogs developed ulcers after 4-5 days of stimulation. It is concluded that the AR operation is heavily ulcer-prone and that PCV does not protect sufficiently against ulceration.

Animals↗
PubMed1979

Common bile duct pressure and Oddi sphincter pressure in patients with common bile duct stones with and without juxta-ampullar diverticula of the duodenum.

Resting common bile duct pressure and Oddi sphincter pressure were measured in 16 patients with common bile duct stones, 8 having in addition a juxta-ampullar diverticulum. Pressure measurements were performed with an infused catheter introduced through an endoscope under direct vision. No significant differences in fasting common bile duct pressures were observed between the two groups. The Oddi sphincter had a phasic activity, and the peak pressure was similar in both groups.

Aged↗
PubMed1979

Bile-induced chronic gastric ulcer in swine with excised oxyntic gland area.

After excision of the oxyntic gland area in seven miniature pigs and cholecystogastrostomy in six of them, two developed chronic gastric ulcers in the gastric remnant. No parietal cells were found in the two pigs with ulcers, whereas small areas with polypoid oxyntic mucosa were found in four pigs without ulcer. The study indicates that bile-induced chronic gastric ulcer can occur in the pig despite the absence of oxyntic cells.

Animals↗