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Biomedical subjects

A Krug

Publications and source records attributed to A Krug.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Stenosis of the sigmoid due to endometriosis (author's transl)].

The diagnosis and treatment of the rare stenosis of the sigmoid due to an attack of endometriosis is discussed in relation to 5 cases. Particular attention must be paid to the lack of involvement of the intestinal mucosa at the preliminary examination. The problems of definitive diagnosis arising from this, which can usually only be discovered by laparotomy, are gone into. Surgical treatment, in the form of a resection to maintain continuity is the appropriate and optimal therapy for this disease. But extensive mutilating operations on establishment of an endometriotic stenosis are not justified.

Adult↗
PubMed1975

Alterations in myocardial hydrogen ion concentration after temporary coronary occlusion: a sign of irreversible cell damage.

Alterations of hydrogen ion (H+) concentration in the myocardium of 60 cats were determined before release of coronary ligation of 30, 45, 60, 90 or 180 minutes' duration, or 5, 30 and 90 minutes after release of the occlusion, by pressing pH indicator paper on unfixed frozen heart sections. The H+ concentration had clearly increased (pH less than 6.0) in a transmural extension in the left ventricle before release of the coronary ligature. This elevated H+ concentration persisted some time in the subendocardial region despite release of the coronary occlusion, thus proving that the so-called no reflow phenomenon exists in involved myocardium after temporary coronary occlusion. A diminished H+ concentration (pH 7.4) was found in the border zone between the acid-reacting area and the normal muscle when the coronary occlusion lasted 180 minutes before release of the ligature or 30 minutes after release of the occlusion when the previous period of temporary occlusion had been longer than 30 minutes. Although areas manifesting an acid reaction vanished or diminished in size after release of coronary occlusion, the extent of alkaline-reacting zones showed no reduction in size, and muscle cell necrosis developed in these alkaline-reacting areas. It is assumed therefore that an alkaline reaction of the myocardium is an early sign of irreversible muscle cell damage.

Animals↗
PubMed1975

[Animal experiments on influencing ischemic myocardial damage following temporary coronary artery ligation].

Ischemic myocardial damage produced by temporary coronary artery occlusion of 60 min duration is diminished by beta-sympathicolytic acting TrasicorR (3 mg per kg) and osmotically cell-dehydrating Manitol (1 g per kg). Trasylol, a proteinases inhibiting substance, caused a favourable effect at very high doses (100 000 DIE per kg) only. The extent and irreversibility of myocardial ischemic damage was determined by experiments of 180 min duration by intravital fluorochromatisation with acrine orange, determination of hydrogen ion concentration at frozen section of heart muscle with pH-indicatorpaper and enzymehistochemical and histochemical methods.

Animals↗