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Biomedical subjects

A Krivitzky

Publications and source records attributed to A Krivitzky.

49 records · Page 3Linked to original sources
PubMed1980

[Cushing's syndrome caused by a bilateral adrenal adenoma (author's transl)].

An unusual of bilateral adrenal benign adenoma with Cushing's syndrome is reported. Nine months after bilateral adrenalectomy, no more sign of hyperadrenocorticism was present. An adenoma was found in each gland with adjacent tissue atrophic. Physiopathology is not clear even if suppression test by dexamethasone and stimulation test by lysin-vasopressin are compatible with a central origin.

Adenoma↗
PubMed1979

[Critical study of the treatment of Grave's disease (author's transl)].

202 cases of Grave's disease were reviewed; among the 81 patients submitted to medical treatment, 53,1 p. 100 of patients failed to respond; 10 p. 100 relapsed and 35,9 p. 100 are euthyroid. The factors favouring a treatment failure were: age below thirty, severity of thyrotoxicosis, big enlargement of thyroid gland, duration of treatment shorter than 12 months. Relapses are more frequent after two years of medical treatment. Subtotal thyroidectomy was performed in 82 patients: 9,5 p. 100 relapsed, permanent hypothyroidism developed in 30,5 p. 100 and 50 p. 100 were euthyroid. The factors favouring post-operative hypothyroidism are estimated weight of the thyroid remnant, the moderate size of goiter and perhaps a six to twelve months preoperative medical treatment. 39 patients had I 131 therapy: among them, 24 p. 100 relapsed, 25,7 p. 100 had permanent hypothyroidism and 50,3 p. 100 are euthyroid.

Adolescent↗
PubMed1978

[Partially hormone dependent bilateral malignant polyadenomatous hyperplasia].

Bilateral malignant polyadenomas of adrenals seem to be rare. They involve either a double primary adrenal tumour, or a metastasis of a controlateral tumour. In the observation reported here, the evolution is characterized by periods of central stimulation with partial autonomy, and periods of tumoral autonomy with central inertness. Pathological findings consist of coexistence of various histological aspects (atrophy, hyperplasia, benign adenoma, carcinoma) suggesting the successive steps of a very particuliar adrenal carcinogenesis. Such findings allow to discuss the following physiopathological mechanism: a stimulation by ACTH might have resulted initially in a preneoplasic hyperplasia, then in an incompletely autonomous tumour, and finally in an autonomous tumour. Accordingly, from a practical and therapeutic point of view, it would be suitable, after removal of an adrenal tumour, especially of one with demonstrated ACTH-dependance, to suppress totally endogenous ACTH by cortisol or cortisone therapy, in order to reduce the occurence of corticotropin stimulation of possibly remaining malignant adrenal cells.

Adenoma↗
PubMedDate not supplied

[Autochthonous malaria and malarian liver. Apropos of 1 case].

Report of the case of a patient, store-keeper at the Roissy airport, suffering from an autochtonous primo-invasion falciparum malaria. The clinical symptoms were hectic fever and painful hepatomegalia, followed 14 days after by a typical tertian fever. All investigations being negative, a laparoscopy was carried out, which showed a black liver, and a biopsy demonstrated the malaria pigment in Küpffer cells. Malaria was confirmed by the study of a blood smear. This diagnostic hypothesis had not been raised, because of the absence of any epidemiologic argument. It seems necessary to think of autochthonous malaria among the etiologies of prolonged summer fevers in people living or working in the neighbourhood of airports, the more so that the frequency of this peculiar mode of contamination should logically increase.

Adult↗
PubMedDate not supplied

[Fatal polyarteritis nodosa following Graves' disease (author's transl)].

Polyarteritis nodosa (PAN), with a fatal outcome, developed during the course of a therapeutically controlled Graves'disease. A review of the published literature confirms that two mechanisms may be involved in the onset of PAN in hyperthyroid patients: an immune response, which is probable in the case reported, or a toxic effect related to the treatment of the hyperthyroidism. This case also emphasizes the therapeutical difficulties encountered, in spite of the corticoid and cyclophosphamide associated treatment with plasmapheresis.

Adolescent↗