Circadian profiles of the serum levels of cortisol and five androgens were studied in 20 females including 8 controls, 7 patients with ACTH-dependent Cushing's syndrome and 5 with hypercortisolism due to adrenal adenoma. A significant 24-h periodicity was found for each steroid in all groups. Besides hypercortisolaemia, a significant increase of 11-hydroxyandrostenedione was shown in both forms of Cushing's syndrome. The most conspicuous finding was a decreased dehydroepiandrosterone and its sulphate in adrenal adenoma. The peaks for the studied steroids were shifted from the morning hours towards the noon in ACTH-dependent Cushing's syndrome and towards the evening (for cortisol) and night hours (for androgens) in adrenal adenoma.

Adenoma↗

PubMedDate not supplied

[Comparison of the diagnostic contribution of rheography and ultrasound in diabetic macroangiopathy of the lower extremities].

In a group of 140 patients with diabetes mellitus ultrasonographic Doppler examination revealed a 30% incidence, rheographic examination a 34% incidence (p greater than 0.05) of macroangiopathies of the lower extremities. The asset of rheography was the ability to differentiate between pathological functional (21% incidence) and organic changes (13% incidence). The contribution of sonographic examination was the localization of the portion most severely affected by the macroangiopathy. The most frequent variant was general affection of the distal portion of extremities, followed by predominating affection of the posterior tibial artery and affection of the entire circulation of the lower extremity. In the authors' practice rheography is the basic examination. In the event of revealed pathological changes it is supplemented by sonographic Doppler examination.

Adult↗

PubMedDate not supplied

[Multicenter study with gliquidone in type 2 diabetes mellitus].

The effectiveness and tolerance of the new sulphonyl urea antidiabetic gliquidone (commercial name Glurenorm) was tested by three-month administration of this preparation in a group of 39 type 2 diabetics. Gliquidone proved a medium-strength beta-cytotropic antidiabetic preparation. As to side-effects, the authors noted only dyspepsia in one patient (2.5%). Symptomatic hypoglycaemia did not develop in any of the patients. In the subgroup of six patients with diabetic nephropathy the indicators of renal functions did not deteriorate. In a sub-group of 6 patients with concurrent hepatopathy the originally elevated gamma-glutamyl transpeptidase activity receded. The authors confirmed thus the good tolerance of gliquidone in diabetes associated with nephropathy and diabetes with hepatopathy.

Adult↗