Biomedical subjects
A Krakowski
Publications and source records attributed to A Krakowski.
Unusual immunofluorescent pattern in leishmaniasis (oriental sore).
Skin lesions of acute cutaneous leishmaniasis were found in three healthy men. A smear for Leishman-Donovan (LD) bodies as well as histopathologic studies of the lesions confirmed the diagnosis. Direct immunofluorescent studies of the lesions revealed deposits of immunoglobulins and complement in dermoepidermal junctions and fibrinogen in dermal blood vessels.
Pediculid. An unusual -id reaction to pediculosis capitis.
We describe a pruritic rash that appears to be associated with pediculosis capitis. We suggest calling it ' pediculid ' since it appears to be an -id reaction to pediculosis capitis.
[Pemphigus folliaceous following D-penicillamine in rheumatoid arthritis].
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Miconazole treatment for cutaneous leishmaniasis.
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Alkaline phosphatase immuno-enzymatic technique in the diagnosis of pemphigus vulgaris.
Alkaline phosphatase was used in an immuno-enzymatic procedure to detect tissue-bound and circulating antibodies in pemphigus vulgaris. Pemphigus antibodies were revealed by a direct method using alkaline phosphatase conjugated goat anti-human IgG. Cryostat sections were incubated with the specific antiserum, and alkaline phosphatase activity was then revealed histochemically either by Gomori's technique or by the azo dye method. The sections were examined by light microscopy and intercellular staining was demonstrated in the epidermis. The indirect method, in which the patient's serum was incubated with sections of normal skin, gave similar results. Using parallel sections, an immunofluorescent technique was used to demonstrate tissue-bound and circulating antibodies. The alkaline phosphatase method appeared to be slightly less sensitive than the immunofluorescent method.
Perforating cutaneous mucinosis.
A case is described in which a papulonodular eruption developed all over the body. Histologic examination of one of the lesions revealed the dermis to contain mucin (hyaluronic acid). In some areas there was perforation through the epidermis of the mucinous material.
Puva-Sol therapy at the Dead Sea in mycosis fungoides.
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An unusual pattern of arthritis dermatitis syndrome.
A 27-year-old woman presented with skin lesions and arthritis of the right knee of two days' duration. Her medical history was noncontributory and synovial fluid aspirated from the affected knee and a biopsy of a skin lesion were negative for gonococci. However, after methylene blue staining of cervical and urethral smears, intracellular and extracellular diplococci were demonstrated. Immunofluorescence showed deposits of immunoglobulin complexes of the skin section within the wall of blood vessels and dermal-epidermal junction. Treatment with ampicillin, 4 gm a day, resulted in resolution of the lesions and arthritis in two days. The need for cervical and urethral smears and for better, as yet unavailable tools for the diagnosis of the arthritis dermatitis syndrome, is emphasized.
Angioimmunoblastic lymphadenopathy with scleromyxedema-like lesions and serum monoclonal protein.
A patient was followed up for 5 yr for an illness diagnosed histologically as angioimmunoblastic lymphadenopathy. His serum contained a monoclonal protein of the IgM type, and biopsies from papular skin lesions revealed scleromyxedema-like features. The unusual association of this kind of cutaneous lesion with angioimmunoblastic lymphadenopathy and a monoclonal IgM is discussed.
[Oral retinoids--progress in medicine].
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Keratinization index.
A method to decrease subjectivity in assessing hyperkeratosis by application of quantitative measurements is proposed. The proportion of the depth of the stratum corneum to that of the total epidermis was measured on stained sections of tissue and termed the keratinization index (K.I.). Determinations showed that the K.I. varied with anatomical regions and was greater in different types of ichthyosis than in normal samples. Two indices were assessed, namely, K.I. which describes the ratio of cornified layer to total epidermis measured to the tips of the dermal papillae, and K.I. measured to the bases of the rete ridges. These two indices reflect the contour of the dermo-epidermal junction.
Increased frequency of HLA-Aw19 in Kaposi's sarcoma.
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The water cushion in dermatological diagnostic ultrasound. A new method.
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Impetigo herpetiformis with lowered serum level of vitamin D and its diminished intestinal absorption.
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Psoriasis of the lips: the unusual Köbner phenomenon caused by protruding upper teeth.
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Kaposi-like arteriovenous malformation and angiodermatitis (pseudo-Kaposi).
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Multiple agminated juvenile melanoma: a case with a sunburn history, and a review.
Multiple agminated and two isolated juvenile melanomas in a 4 1/2-year-old boy, which appeared on apparently normal skin after sunburn, are described. Cases in the literature are reviewed.