Search PubMed⌕ Search

Biomedical subjects

A Koshy

Publications and source records attributed to A Koshy.

At least 73 records · Page 4Linked to original sources
PubMed1982

In vivo and in vitro drug metabolism in patients with leprosy.

Plasma antipyrine and chloramphenicol clearance was studied in 23 patients of leprosy and 12 control subjects. Drug metabolising enzymes (aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase) were estimated in liver biopsy samples of twelve patients and ten controls. A significant decrease in drug clearance and drug metabolising enzymes was observed. However, no significant correlation could be obtained between drug half lives and drug metabolising enzymes or with any of the liver function tests in these patients. The findings indicate that drug metabolism is impaired in leprosy patients.

Adolescent↗
PubMed1981

Kinetics of lymphocyte subpopulations and their functions in cases of amoebic liver abscess.

This study shows the relationship between lymphocyte subpopulations and their response to non-specific stimulant phytohaemagglutinin (PHA) and specific stimulant (amoebic antigen) in cases of amoebic liver abscess in relation to the duration of disease, based on the first appearance of symptoms and/or signs, 26 patients with amoebic liver abscess and 20 normal, healthy controls were studied. Five of the patients gave a history of alcohol intake for the last 10 to 15 years. Eight had a solitary abscess and five had multiple abscesses, as seen on liver scan. No change in the B cell count was noticed in any of the patients. Depression of the T cell number and function was noticed from two weeks onwards. A history of alcohol intake made no difference. Cases with multiple liver abscesses were more immunologically depressed than were those with a solitary abscess.

Alcoholism↗
PubMed1980

Hydatid disease associated with hepatic outflow tract obstruction.

Three unusual cases of hydatid disease associated with hepatic outflow tract obstruction are presented. One had Echinococcus multilocularis infection with complete obstruction of the inferior vena cava and the other two had E. granulosus infection with complete obstruction of the hepatic vein. The initial two were unsuspected clinically. The cases suggest that both outflow obstruction and hydatid disease may often be unrecognized. A high index of suspicion and appropriate investigation are essential for diagnosis and proper management.

Adult↗
PubMed1979

Amebic liver abscess with hemobilia.

A patient with hemobilia complicating an amebic liver abscess is described. The diagnosis was based on selective arteriography. The hemobilia did not stop with antiamebic treatment or ligation of the right hepatic artery. Successful results followed right hemihepatectomy.

Adult↗
PubMed1978

An unusual outbreak of hookworm disease in North India.

An unusual outbreak of hookworm disease occurred after a game of "kabaddi" (a local game which results in much body contact with the ground) in 27 young males from one village. It was characterized by an immediate incapacitating dermatitis, followed by severe pulmonary symptoms. Progressive weakness, abdominal pain, weight loss and anemia developed within a few months. Ancylostoma duodenale was found in all except four patients who had received antihelminthic treatment. Specific treatment for hookworm resulted in complete clinical recovery. Features of the outbreak were: 1) the hitherto unrecorded mode of infection; 2) severe dermatitis; 3) pulmonary symptoms lasting more than 3 mo; 4) abdominal symptoms suggestive of subacute obstruction starting 4-6 mo after exposure; and 5) severe disability with weight loss for a period of 1 yr until specific treatment was administered.

Adolescent↗