A method for the easy combination of several methods of examination for tubal patency.
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Dye Dilution Technique↗
Biomedical subjects
A Konno
Publications and source records attributed to A Konno.
Role of the vidian nerve in nasal allergy.
Clinical studies were performed to evaluate the role of the vidian nerve at onset of symptoms in nasal allergy. A localized area of one side of the nasal cavity was stimulated with known allergen and 0.1% histamine chloride in patients with perennial nasal allergy. The effect of unilateral vidian neurectomy and sensory anesthesia on glandular and vascular response was evaluated. With localized nasal stimulation, hyperrhinorrhea was seen in both sides of the nasal cavity before vidian neurectomy. Unilateral vidian neurectomy blocked hyperrhinorrhea only in that nasal cavity in which the nerve was sectioned. However, hyperrhinorrhea from the contralateral side, with an intact vidian nerve, was blocked with sensory anesthesia of the opposite side of the nasal cavity where the stimulation was applied. Nasal hypersecretion in allergic rhinitis was assumed to be mostly due to stimulation of sensory receptors by a chemical mediator and reflexive stimulation of the nasal glands. Vidian neurectomy, however, did not have any apparent influence on the swelling of the nasal mucosa caused by localized stimulation of allergen and histamine.
Airway Resistance↗
A study on the pathogenesis of recurrent parotitis in childhood.
Roentgenologic, histopathologic, electron microscopic, virologic and immunologic studies were performed to investigate the etiologic features of recurrent parotitis in children. When examined sialographically and histopathologically, it was considered that pathologic changes in the parotid gland had developed as latent chronic inflammation with mild glandular destruction long before the disease became manifest clinically with acute exacerbation. Proliferation of the duct epithelium in the regenerative process and increase of intraductal pressure due to obstruction of the salivary outflow were assumed to be the causative factors of dilative changes of the peripheral ductal system. Investigation of complement fixation antibody, hemoagglutination inhibition antibody and neutralization antibody responses to mumps virus showed that onset of the disease was unrelated to mumps infection in the majority of cases. Increase of complement fixation antibody titer to various viruses was observed in many cases during acute exacerbation, and were considered to have brought about secondary ascending bacterial infection of the parotid gland by lowering of the systemic resistance. Comparison of serums IgA, IgG, IgM and salivary IgA in these patients with those of control children did not reveal participation of immunodeficiency in the development of this disease. But judging from the results of the long-term clinical follow-up study it was difficult to disregard the possibility that physiological immaturity of the immune response in young children may play some role in onset and recurrent exacerbation of the disease.
Antibodies, Viral↗
Analysis of factors affecting complications of carotid ligation.
A study of 156 patients subjected to common carotid ligation in the treatment of head and neck carcinoma was made to investigate the influence of selected factors on cerebral complications. In the analysis complications were grouped as death or coma; death, coma, hemiplegia or monoplegia; and transitory cerebral symptoms. Primary independent variables included method of occlusion (abrupt, gradual); duration of occlusion; and collateral circulation via the external carotid artery (intact, ligated external carotid artery). Death or coma occurred in 24 cases (15.4%) and complications including death, coma, hemiplegia or monoplegia occurred in 47 cases (30.1%). Although no statistically significant difference between abrupt and gradual occlusion cases was noted, the incidence of cerebral complications was significantly lower for the group with gradual carotid occlusions performed over 13 days (6.3%) than for those with abrupt occlusions or gradual occlusions performed in less than five days. The incidence of death or coma following carotid artery occlusion was 10.5% in cases with an intact external carotid artery, as against 25.5% in those with a ligated external carotid artery, a statistically significant difference. Cerebral complications occurred within 48 hours after carotid occlusion in 35 of 47 cases (74.5%) in which complications developed. In the remaining 12 cases (25.5%) complications developed after 48 hours. There was no difference between abrupt and gradual occlusion cases in the incidence of complications after 48 hours.
Carotid Arteries↗
Effect of sex hormones on eosinophilic inflammation in nasal mucosa.
We examined the effects of sex hormones on the functions of eosinophils. Treatment of eosinophils with beta-estradiol significantly enhanced the eosinophil adhesion to human mucosal microvascular endothelial cells (HMMEC), and eosinophils stimulated by a combination of beta-estradiol and progesterone showed significant induced degranulation. On the other hand, testosterone significantly reduced the eosinophil adhesion to HMMEC and eosinophil viability. The experiments from the series of studies might provide a partial explanation for the aggravation of asthma and some forms of rhinitis that occurs during pregnancy.
Adult↗
Participation of vascular reflex in mucosal swelling in nasal allergy.
A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, the mucosa of the ipsilateral nasal cavity became swollen, with a concomitant increase in mucosal blood flow. In the contralateral nasal cavity, however, an increase in mucosal blood flow was not necessarily accompanied by mucosal swelling. An increase in mucosal blood flow on antigenic challenge was observed even in nasal mucosa, most of the parasympathetic and sympathetic innervation to which was transected by vidian neurectomy. Vascular reflex certainly participates in nasal allergy but it is not always related to mucosal swelling. Mucosal swelling in nasal allergy is considered to be caused mainly by a direct effect of chemical mediators on nasal vasculature and partly by vascular reflex.
Adolescent↗