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Biomedical subjects

A Konno

Publications and source records attributed to A Konno.

At least 217 records · Page 12Linked to original sources
PubMed1981

The origin of the non-specialized epithelial cells cultured from human parotid gland.

We investigated the origin of the non-specialized cells proliferated in primary explant culture of human parotid gland. The predominant cells in surface layer were morphologically epithelial origin with desmosomes and intercellular digitations. The cultured cells did not show any specific affinity to parotin isolated from bovine parotid gland, which seemed to be one of the marker for duct cell. However, it was demonstrated autoradiographically that DNA synthesis in the cells was rapidly induced by isoproterenol, a potent stimulator of acinar cell. From these results, the non-specialized epithelial cells in explant culture seemed to be derived from acinar cell in human parotid gland.

Amylases↗
PubMed1981

Intrasplenic pseudocyst of the pancreas.

We describe a rare case of pancreatic pseudocyst developing in the spleen as a sequel to chronic pancreatitis in the absence of a recognizable pseudocyst in and around the pancreas. We assume that pancreatic secretions escaped through a tight adhesion between the tail of the pancreas and the splenic hilum.

Humans↗
PubMed1981

Primary reconstruction after total or extended total maxillectomy for maxillary cancer.

Conventional total and extended total maxillectomy for maxillary cancer have frequently brought about severe facial deformity and functional impairment. To minimize these postoperative problems, we have applied primary reconstructive procedures utilizing chiefly the deltopectoral flap with or without bone grafting in 46 patients. The results were fairly satisfactory judging not only from postoperative cosmetic and functional viewpoints but also from evaluation of long-term survival rate of maxillary cancer. Primary reconstruction was most advantageous because it allowed sufficient resection of the maxilla and surrounding tissue without much regard for postoperative problems. Indications and details of our reconstructive procedures were described and discussed.

Cleft Palate↗
PubMed1980

A physiologic study on respiratory handicap of the laryngectomized.

Lack of the upper airway function after laryngectomy creates unfavorable effects on the lower respiratory tract. The purpose of this study is to re-evaluate this relationship objectively. Respiratory function tests were performed on 13 laryngectomized patients. Pulmonary volumetry and ventilometry revealed increased RV and FRC, and decreased FEV1.0%, indicating evidence of obstructive changes in the lung, MEFV-recordings showed greater downward convexity than those of the normal at the lower volume level. The value of MEF50/body-height was definitely smaller than normal average in the same age group. Pulmonary resistance was in wide variety but definitely lower than normal because of lack of the upper airway resistance. If this component is added to the value, the total will be in normal range or even higher. Dynamic compliance remained mostly in the normal range when measured using a mask at the tracheostoma. The value was lower than normal when measured through a cuff-canula. The difference in static and dynamic compliances was greater than that in normal cases, which may indicate evidence of uneven distribution of air in the lung. Regular check-up and suitable respiratory care are recommended on the laryngectomized.

Airway Obstruction↗
PubMed1980

The specific binding of parotin on duct cells of human parotid gland.

The relationship between parotin and human parotid gland was investigated using indirect technique of enzyme antibody method. Normal rabbit IgG has non-specific affinity to duct cells of human parotid gland, but it was suppressed by adding bovine serum albumin. Anti-parotin rabbit IgG has no reaction products on the sections of adult human parotid gland. When the sections, initially incubated with parotin solution in PBS, were treated with anti-parotin rabbit IgG containing bovine serum albumin, and then HRPO-labeled anti-rabbit gamma globulin antibodies (swine IgG), intercalated and striated ducts excepting excretory ducts were stained with diaminobenzidine reaction, but also acinar cells did not. These results indicate that parotin is bound specifically on duct cells of human parotid gland.

3,3'-Diaminobenzidine↗
PubMed1980

The effect of nasal obstruction in infancy and early childhood upon ventilation.

To evaluate the effect of nasal obstruction in infants and young children upon ventilation during sleep, change of ventilation was followed by polygraphic recordings of esophageal pressure, tidal volume and percutaneous oxygen tension when the nostrils were mechanically obstructed in 10 subjects; 3 types of ventilatory changes were noted. In 4 subjects periodic breathing appeared in which hypoventilation was alternated with occasional hyperventilation. Esophageal pressure, tidal volume and PO2 showed concomittant fluctuation. PO2 lowered during hypoventilatory phase was compensated by periodic hyperventilation. In 5 subjects upper airway obstruction was compensated for by increased respiratory endeavor and tidal volume and PO2 remained normal in spite of markedly increased esophageal pressure. In 1 subject tidal volume and PO2 remained decreased with marked increase of esophageal pressure. Largest airway obstruction was noted between the upper and the lower lips.

Airway Obstruction↗
PubMed1980

Analysis of the results of our combined therapy for maxillary cancer.

The study was performed in 70 patients with maxillary cancer to evaluate how far the long-term survival rate of the maxillary cancer can be improved with maximum combination of radiation therapy using 6 mV Linac X-ray, intra-arterial chemotherapy using 5-fluorouracil, sufficiently extensive maxillectomy and primary reconstruction. In 52 cases of squamous cell carcinoma, the 3-year and 5-year actual survival rates were 85.2% and 71.1% respectively. In the total 70 cases including those of undifferentiated carcinoma and adenocarcinoma, the 3-year and 5-year actual survival rates were 75.2% and 64.1% respectively. Primary reconstruction, which consisted chiefly of covering the entire wound surface with the deltopectoral flap, enabled us to perform as much resection of the subcutaneous tissue of the facial skin, tissue around the mandible and cranial base as necessary, without consideration of the postoperative facial disfigurement and functional impairments.

Adenocarcinoma↗
PubMed1980

Influence of upper airway obstruction by enlarged tonsils and adenoids upon recurrent infection of the lower airway in childhood.

The influence of hypertrophied tonsils and adenoids upon ventilation during sleep was evaluated by polygraphic recording before and after adenotonsillectomy. In all 19 cases, esophageal pressure during sleep was elevated as high as 4-6 times normal. This was caused by nasal obstruction due to adenoid hypertrophy and obstruction of the "oral airway" by hypertrophied tonsil and collapse of the tongue due to muscular relaxation during sleep. When minimal amount of contrast media was instilled slowly into the nasopharynx aspiration of the contrast media into the lung was found significnatly more frequently in subjects with upper airway obstruction. Active aspiration of the secretion by marked inspiratory negative pressure during sleep may play a major role in causing recurrent infection of the lower airway frequently seen in these children.

Adenoids↗
PubMed1977

Computed tomography of the paranasal sinuses and their adjacent structures.

Forty-five computed tomographic examinations were performed on 34 patients with diseases of the paranasal sinuses and their adjacent structures. Coronal sections were obtained in addition to transverse axial tomographic sections. Evaluation was made whether CT could provide more informations compared with plain roentgenography and whether there were additional informations on coronal sections. CT showed soft tissue abnormality and its extension to better advantage. Especially, involvement of the orbits, pterygoid fossa, nasopharynx, skull base and brain were shown well. Coronal sections were useful in evaluation of superior and inferior extension of the tumors such as involvement of the superior and inferior orbital walls and skull base as well as intracranial extension. Since CT has the ability to better define the total extent of the lesion, this technique should be added to the conventional roentgenologic techniques preferably with the use of coronal sections.

Bone Diseases↗