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Biomedical subjects

A Koch

Publications and source records attributed to A Koch.

At least 307 records · Page 17Linked to original sources
PubMed1979

Evaluation of smoking-induced effects on sympathetic, hemodynamic and metabolic variables with respect to plasma nicotine and COHb levels.

The effect of smoking cigarettes containing 1.5 mg and 0.08 mg nicotine per cigarette and of sham-smoking was studied in six healthy habitual smokers. Levels of carboxyhemoglobin (COHb) and plasma nicotine were measured simultaneously with hemodynamic variables, such as heart rate and blood pressure, and with the metabolic parameters, plasma DBH, cortisol, blood glucose, lactate and free fatty acids. All variables, with the exception of COHb are dose related to plasma nicotine levels. Blood pressure, heart rate and lactate show simultaneous peaks together with maximal nicotine levels, while DBH and cortisol, blood glucose and free fatty acids show a delayed reaction compared to nicotine concentrations. No effects of COHb, even with levels up to 5.6 +/- 0.5% have been observed on the variables investigated. These results demonstrate, that it is nicotine which induces considerable hemodynamic and metabolic alterations after smoking.

Adult↗
PubMed1978

[Function of the lower esophageal sphincter in infants].

Main basal pressure and the deglutition-induced behavior of the lower esophageal sphincter (LES) in 115 infants between the ages of 6 hr and 6 mo were evaluated by continuous perfusion manometry. In comparison to the adult, higher pressures were found, especially in the first weeks and months of life. The relaxation stimulated by the deglutition reflex and the pressure increase following abdominal compression were similar to the responses observed in adults. Singificant differences between vomiting and nonvomiting infants could be determined. From these results we conclude that the vomiting often observed in early infancy results from factors other than the previously proposed hypotonia or neuromuscular underdevelopment of the LES.

Deglutition↗
PubMed1977

[Pelvic fractures in children: clinic, late results, biomechanic (author's transl)].

From 1917--1976 68 pelvis fractures of children (up to 14 years) were hospitalized at the department of Surgery, University of Göttingen. About 75% were traffic accidents. The lesions prefer the iliosacral joints, symphysis and the biogenic connections. Experimental compressions confirm the clinical fractures. The controls show sufficient subjective results. Because of pelvis dislocation and scoliosis controls are necessary.

Accidents, Home↗
PubMed1977

[Raynaud's phenomenon in dialysed patients (author's transl)].

In 158 uraemic patients on haemodialysis complaints resembling Raynaud's disease were observed more frequently (85 patients = 54%) than in an equal number of age and sex matched control persons (10 probands = 6%). The complaints were also registered in the arm without the fistula. Triggering causes were exposure to cold or isometric muscular exercise. The complaints were slightly more frequent in women and occurred in 28% prior to dialysis in the terminal stage of renal insufficiency. They were improved only in a minority of those treated with haemodialysis, however they disappeared after successful renal transplantation. Veno-occlusive plethysmographic investigations showed that in asympatomatic patients the resting perfusion at room temperature, the perfusion in reactive hyperaemia, and perfusion at 0 degrees C were not different from control persons. Patients with Raynaud's phenomenon had on average a diminished resting perfusion and a normal perfusion after reactive hyperaemia. The perfusion at 0 degrees C was lower than in asymptomatic patients but still higher than in patients with Raynaud's disease. Increased cooling of the skin and delayed rewarming were objectively measured by using skin temperatures. There was not correlation between the complaints or perfusion values and the vibration threshold.

Adolescent↗
PubMed1976

[Urodynamic measurements in enuretics].

Distal urethral stenosis in girls as well as meatal and bulbar narrowed urethral segments in boys are still subjects of discussion about their pathologic value in the literature. The urodynamic findings in enuretic children by urethral pressure profile and cystometry frequently point to a outflow resistance. Calibration with bougies à boule, urethroscopy and permictional cysturethrography disclose such urethral narrowing. The survey of our own 107 enuritic children shows that urethrotomy has given good results relative to urodynamic data. The effect of methantheline medications consists in suppressing the hyperactivity of the detrusor.

Child, Preschool↗
PubMed1976

[Effects of temperature and light variations, and of radiothyroidectomy on body weight regulation in the European hamster (Cricetus cricetus) (author's transl)].

Regain of body weight in European Hamsters after fasting was investigated at various periods of the year and under different ambient conditions (fig. 1) with and without radiothyroidectomy. 1. Weight gain after food deprivation proceeds at rates which vary with the season. It is faster in spring and summer than in winter. 2. Variations in ambient temperature and in light conditions do not influence the daily weight gain and the relative rate of weight increase (fig. 2,3). 3. Radiothroidectomy depresses these two parameters in winter as well as in spring, and lowers the level of the set point of the regulating mechanism (fig. 4,5).

Animals↗
PubMed1975

[Fine structure of venules and lymphatics of the dog thyroid gland].

The endothelial cells of the venules (collecting venules) of the thyroid gland of the dog are very thin and show fenestrations. In their wall, however, more 'primitive' smooth muscle cell layers are recognizable. The endothelial cells in the lymphatic vessels are also thin, but continuous. They have all known morphological characteristics of these vessels. The fenestrae of the venules' endothelium could facilitate hormone passage from the interstitial tissue into the blood stream.

Animals↗