Predicting distributed retinal source activity from ERG data--Part I: Field theoretic approach.
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Biomedical subjects
Publications and source records attributed to A Koblasz.
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The electroretinogram (ERG) and electro-oculogram (EOG) are two of the most frequently used visual electrodiagnostic tests of retinal function. The ERG and EOG are easily measured, but there are many engineering difficulties in processing their signal data because the response amplitudes are relatively small, and the relevant signals are buried in electromagnetic and biologic noise. These tests tend to be time consuming, so they lend themselves to automatic control. This article describes the engineering designs relative to a microprocessor-based electrophysiologic laboratory at Emory University Clinic to perform ERG, EOG, and other clinical tests of retinal function. A comparable system that offered both the ability to accept data from a variety of transducers and the flexibility to permit all of the planned testing protocols was not available from any commercial source.
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The linear and nonlinear operations of a biological system can be represented by a set of functions called Wiener kernels. This type of analysis is becoming increasingly important in the field of biological systems analysis. This paper reviews the theoretical and practical aspects of testing a biological system with white-noise and provides a guide for interpreting Wiener kernels which result from such studies. A study of the human electroretinogram is presented as an example.
This report describes a cup electrode for measuring the human electroretinogram which improves the comfort of a subject while providing sufficiently large signal-to-noise ratios for most applications. The cup electrode is demonstrated by measuring the electroretinogram for small-amplitude flash stimuli.