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Biomedical subjects

A Knight

Publications and source records attributed to A Knight.

101 records · Page 6Linked to original sources
PubMed1968

Rhinitis and polyps.

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Diagnosis, Differential↗
PubMedDate not supplied

The toxicity and bioaccumulation of selenate, selenite and seleno-L-methionine in the cyanobacterium Anabaena flos-aquae.

A laboratory investigation was conducted to study the toxicity and bioaccumulation of seleno-L-methionine, selenate and selenite in the cyanobacterium Anabaena flos-aquae. The first sub-lethal effects of seleno-L-methionine, selenite and selenate occurred at 0.1, 3.0, and 3.0 mg/L, respectively with a decrease in chlorophyll a concentration (P less than 0.0001). Selenium bioconcentration factors (BCF) were in the order of seleno-L-methionine, selenite, and selenate. Significant decreases in intracellular selenium concentration were observed at both the no effect (NOEL) and low effect levels (LOEL) at each oxidation state tested in the given experiment (p less than 0.0001). Mechanisms for the assimilation, toxicity and regulation of selenium are presented.

Cyanobacteria↗
PubMedDate not supplied

Anxiety and depression among medical and surgical patients nearing hospital discharge.

Ninety-eight medical and surgical inpatients were interviewed 24-72 hours prior to discharge. Thirty-five (36%) had clinical levels of anxiety and depression as defined by the SCL-90-R, a self-report symptom inventory. Compared with patients with normal SCL-90-R subtest scores, anxious and depressed patients more often had the following characteristics: older age, black race, lower socioeconomic class, a recent previous hospitalization, and impaired functional status prior to admission. Three to four weeks after discharge, 25 of the 35 anxious and depressed patients were again interviewed. Thirteen remained anxious and depressed, while 11 patients had returned to normative distress levels. Older, black, poor inpatients with a recent prior hospitalization and impaired functional status are at high risk for clinical anxiety and depression. Half of those with anxiety and depression may remain anxious and depressed after discharge. Intervention should be considered for these patients.

Adult↗
PubMedDate not supplied

Sub-zero cooling synchronizes post-diapause development of codling moth, Cydia pomonella.

Sub-zero cooling treatments of -10 degree C and -15 degree C for 2-6 days were evaluated as a means of meeting the chilling requirement of diapause and to synchronize post-diapause development in larvae which were held in diapause for less than 6 months. Sub-zero cooling did not affect male longevity. After six months in diapause, diapause/cooled females were longer lived than diapause control females but not longer than non-diapause females. In general, diapause-cooled males passed more spermatophores than males from control diapause and non-diapause groups. In general, sub-zero cooling did not consistently affect fecundity and % egg hatch. Non-diapause females laid the most eggs after six months in diapause, and diapause-cooled females laid the most eggs after seven months in diapause. The duration of sub-zero cooling had a significant effect on post-diapause emergence in relation to the duration that the larvae were in diapause. Sub-zero cooling for 4 days at -10 degree C significantly reduced the number of days to adult emergence of larvae which had been in diapause for 0-4 months. Sub-zero cooling at -15 degree C for durations of 2, 4, and 6 days had more variable effects on emergence, but in most cases, sub-zero cooling reduced the amount of time to and span of adult emergence.

Journal Article↗
PubMedDate not supplied

The role of levocabastine in the treatment of allergic rhinoconjunctivitis.

Allergic rhinoconjunctivitis is a common atopic condition frequently encountered in clinical practice, with prevalence figures as high as 20% reported. The socioeconomic impact of this condition is considerable--not only in terms of medical costs but lost work and schooldays and quality of life. A wide range of therapeutic approaches is available, including levocabastine, an extremely potent and highly specific H1-receptor antagonist which has been developed for topical application as eyedrops and nasal spray. The available clinical data demonstrate that this agent is well tolerated, with an adverse effect profile comparable to sodium cromoglycate and placebo. Onset of action is rapid, with maximum therapeutic effects typically being observed within minutes of application. Results of comparative clinical trials suggest that topical levocabastine is as at least as effective as oral antihistamines and sodium cromoglycate for the treatment of allergic rhinoconjunctivitis, and it is suggested as an attractive alternative to oral antihistamines as first-line therapeutic option.

Administration, Inhalation↗