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Biomedical subjects

A Klimek

Publications and source records attributed to A Klimek.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Xylose test in patients with attacks of headaches (migraine, Horton's headache)].

The aim of this work was to study digestive tract function by means of xylose test in patients with attacks of headaches. The investigations were carried out in 14 patients with migraine, 10 with Horton's headache and 1 patient with both these conditions. In patients with migraine or Horton's headache the xylose test was normal in 65% of cases, in the remaining 35% (8 patients, 4 in each group) xylose elimination was abnormal, because it was below 30%. The authors discuss the factors which could influence the abnormal results of xylose test in these patients, since they had no signs of other diseases than the mentioned headaches.

Adult↗
PubMedDate not supplied

[Various immunological phenomena in myasthenia gravis. Preliminary report].

The proportions of subsets of T and B lymphocytes and their counts were determined in the peripheral blood in 15 patients with myasthenia. The blastic transformation of these cells was studied after stimulation with mitogens: PHA, Con A and PWM. The serum immunoglobulin level was determined as well. In five thymectomized patients these investigations were repeated during up to two years after the operation. The comparison of the results of these tests in the patients and healthy controls showed differences only in the ability to respond with blastic transformation of the lymphocytes to PHA and Con A. This ability was reduced in some patients with myasthenia. Investigations repeated after thymectomy failed to demonstrate changes in the proportions and counts of T and B lymphocytes, degree of blastic transformation and immunoglobulin levels in relation to prethymectomy values.

Adolescent↗
PubMedDate not supplied

[Platelet aggregation in migraine and other headaches].

In 43 patients with migraine, 20 with Horton's headaches, 13 with trigeminal neuralgia and 50 healthy subjects the circulating platelet aggregates were determined by the method of Wu and Hoak. Moreover, in 23 patients with migraine, 8 with Horton's headache and 21 healthy subjects spontaneous platelet aggregation was determined in platelet-rich plasma with a transmission aggregometer. It was found that the aggregation coefficient was much lower in patients with migraine and Horton's headache than in the control group. In the group with migraine the per cent of spontaneous aggregation in 8 patients differed significantly from the mean value which was similar to that in the control group or in the group with Horton's headache. In the light of these results the authors conclude that significant changes of platelet aggregation occur in migraine and Horton's headache.

Blood Platelets↗
PubMedDate not supplied

[Blood testosterone levels in patients with Horton's headache].

Serum testosterone level was determined by radioimmunoassay in 57 men, including 23 cases of Horton's neuralgia during the period of recurrent headaches but not during an attack of headache, in 10 cases of trigeminal neuralgia, 10 cases of radicular pain and in 14 blood donors. Only in the blood donors this level was normal, in the remaining cases it was statistically significantly decreased, especially in cases of radicular pains. The author believes that in the period of Horton's headaches the testosterone level is decreased due to recurrent attacks of pain and not due to a process involving the hypothalamus.

Adolescent↗
PubMedDate not supplied

[Lithium treatment of chronic Horton's headaches].

The authors used lithium carbonate in treatment of 7 patients with Horton's headaches of primarily or secondarily chronic character. In all patients the blood level of lithium was determined and it was found to reach therapeutic levels. Disappearance of attacks was achieved in 3 cases, significant improvement in 2, and in 2 cases treatment was ineffective. The mechanism of lithium action in this disease is discussed. The authors recommend lithium as worthy of use since other drugs are ineffective in this disease or they cannot be used, eg. steroids or indomethacin, in view of frequent coexistence of paptic ulcer.

Adult↗
PubMedDate not supplied

[Thyrotropic and thyroid hormone (T3 and T4) content in Horton' s headache patients].

In 18 men with Horton's headaches the levels of the following hormones were determined in the serum: TSH, T3 and T4. The determinations were performed during disease relapse and before starting treatment. The control group included 18 blood donors. In the control group the mean TSH level was 3.97 +/- 0.88 microunits/ml, T4 level was 109.06 +/- 26.88 nmol/l, and T3 1.48 +/- 0.14 nmol/l. In the group of patients the mean values were: 2.58 +/- 2.09 microunits/ml, 97.62 +/- 21.81 nmol/l, 1.07 +/- 0.21 nmol/l respectively. The analysis of the results showed statistically significant differences in the concentrations of T3 between the compared groups. In the light of these results the authors believe that there is not sufficient support of the hypothesis on a hypothalamic pathogenesis of the disease. The causes of reduced T3 concentration in these patients are discussed.

Adult↗
PubMedDate not supplied

[Basilar migraine: case report].

The authors describe a case of basilar migraine in 35-year old woman. The diagnostic examinations performed in accordance with our expectations did not show abnormalities. Like other authors we think that the symptoms are caused by disturbances of vascularisation in basilar artery area.

Adult↗
PubMedDate not supplied

[The level of Interleukin-6 in patients with amyotrophic lateral sclerosis].

The role of immune factors in the pathogenesis of ALS is taken into account and, in view of this, it was decided to study the role of interleukins (IL) taking IL-6 as an example. Its concentration was determined in blood and CSF with Amersham RIA kits. The study was carried out on 16 ALS patients and 16 patients with low back pain who served as controls. The IL-6 level in blood and CSF did not vary between these groups statistically significantly. Then from the ALS group the cases with only bulbar symptoms or with predominance of bulbar symptoms were isolated. This subgroup comprised 6 patients, their mean age was higher, and disease duration was shorter. The IL-6 level in the CSF was 27.1 +/- 8.6 nmol/ml and was statistically significantly higher than in the remaining cases. The specificity of this finding is discussed.

Adult↗
PubMedDate not supplied

[Levels of complement and its various fractions in the blood of patients with Horton's headache. Preliminary report].

The pathogenesis of cluster headache remains unexplained and the immunological mechanisms have not been studied in this disease. Suspecting a possible allergic character of headache attacks it was decided to determine the haemolytic activity of the complement system and the levels of its C3 and C4 components. The investigations were carried out in 11 patients with cluster headache and in 10 patients with neurotic symptoms who served as controls. It was found that the levels of complement and its C4 fraction were not different in both groups but the level of C3 fraction showed a statistically significant difference. The authors discuss the obtained results and postulate continuation of investigations.

Adult↗
PubMedDate not supplied

[A case of multiple system atrophy treated with erythropoietin].

The patient, a women aged 52, with a three-year history of treatment for arterial hypotension, was admitted to hospital because of progressing worsening of symptoms. The whole clinical syndrome made possible the recognition of multiple system atrophy as the cause of her symptoms. In view of failures in previous treatment it was decided to give her erythropoietin injections for four weeks. The treatment led to improvement of her status. The authors discuss the probable action mechanism of erythropoietin in this case.

Erythropoietin↗
PubMedDate not supplied

[Traumatic injury of ciliary ganglion].

The authors report a case in which slight cranial trauma was followed by manifestations of damage to the right ciliary ganglion. After 3 weeks the signs of damage began to regress and disappeared completely. Laboratory investigations failed to demonstrate any abnormalities. Apart from this trauma there were no other detectable causes, and especially there were no history data suggesting past infection, botulism or syphilis. The mechanism of ciliary ganglion injury is not known (contusion, haematoma, oedema etc.).

Adult↗