Biomedical subjects

A Kircher

Publications and source records attributed to A Kircher.

4 recordsLinked to original sources

PubMed2000

Knowledge representation forms for data mining methodologies as applied in thoracic surgery.

Typical ways of disseminating and using results of clinical research are scientific journals and reports. Presentation forms are condensed and comprehensible mainly to the experts following the specific topics. A vast amount of information remains unutilized due to the complex form of presenting the knowledge. Subject of this research is to explore possibilities of representation and also visualization of the results obtained using data mining methodologies. The intention is to formulate more than scientific ways to communicate facts that are of interest for the clinicians, medical students and even patients. Internet technologies as already widely established media support knowledge representation forms such as hypertext documents and structured knowledge components. The "Assist Me" decision support system for surgical treatment of cardiac patients integrates several forms of data mining and representation methodologies. We are showing a feasibility study in which scientific outcomes were forwarded to a broad group of potential users.

Artificial Intelligence↗

PubMed1999

Quantitative data analysis for exploring outcomes in cardiac surgery.

The article focuses on possibilities of statistical knowledge exploration to predict outcomes of surgical treatments. The outcomes were defined in relation to the measured peri- and intraoperative data, as well as follow-up patient questionnaire. Clinical consequences are expected in terms of a smaller data set with a better ability to predict the surgery outcomes and a better cost performance. The important questions that could discriminate quality of life (QoL) were: Relief from surgery?, Has cardiac surgery effected earlier symptoms? Work capacity? Consultations after the surgery? The performed data analysis proved to be efficient in the complex data set that was collected. Pain relief was identified to be significant, while relations between measured blood laboratory profile and later QoL were weak.

Aged↗

PubMed1980

[Primary amyloidosis with nephrotic syndrome: 5 year follow-up under polychemotherapy. A case report (author's transl)].

A patient with primary amyloidosis had infiltration of liver, bone and bone marrow and a nephrotic syndrome with massive proteinuria. In addition, there was evidence for a plasma cell dyscrasia with an increased number of plasma cells and other lymphoreticular cell elements in the bone marrow and an impairment of immunoglobulin synthesis without M-gradient. The course of disease was observed over a period of five years. The patient was treated intermittently with a combination of penicillamine, melphalan, fluocortolone and fluoxymesterone. Under treatment the nephrotic syndrome disappeared and liver size decreased. Hemopoiesis remained sufficient but bone marrow infiltration by amyloid did not respond to therapy and massive osteoporosis developed. Comparison of our with other reported cases treated with the same regime suggests that response to this treatment may be influenced by factors such as sex and clinical manifestation of the disease.

Amyloidosis↗

PubMed1980

[CT for staging of systemic lymphatic diseases (author's transl)].

In 75 patients with lymphoma (46 Hodgkin's disease, 29 non-Hodgkin lymphomas) computed tomography was performed in order to detect neoplastic invasion of the abdominal organs (55 new cases) or to control the results of treatment (20 cases). In 30 cases enlarged retroperitoneal or mesenteric lymphnodes and/or liver or spleen enlargement were found. Neoplastic involvement of lymphnodes without enlargement was missed in two cases. CT failed also to demonstrate microscopic malignant invasion of liver and spleen. The false-negative rate in our series was 10.9%. Computed tomography is a non-invasive method which is very well suited for staging malignant lymphoma.

Hepatomegaly↗