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Biomedical subjects

A Khare

Publications and source records attributed to A Khare.

58 records · Page 4Linked to original sources
PubMedDate not supplied

A novel pregnane derivative from Sarcostemma brevistigma.

A new pregnane derivative designated as bregenin [1] has been isolated from the dried twigs of Sarcostemma brevistigma. Chemical and spectroscopic evidence is consistent with the structure 3 beta, 14 beta, 16 alpha, 17 beta tetrahydroxypregn-5-en-20-one for bregenin.

Chemical Phenomena↗
PubMedDate not supplied

Flowcytometric evidence of platelet activation in patients on aspirin following myocardial infarction.

BACKGROUND: Following a myocardial infarction, patients are usually started on long term antiplatelet therapy with aspirin in a dose of 80-150 mg/day. However, there are no quick and easy methods to assess the efficacy of the antiplatelet activity of aspirin. METHODS: We studied 60 consecutive patients (men, < 40 years of age) 8-10 weeks after they had had acute myocardial infarction. These patients were receiving 100 mg aspirin daily orally with or without b-blockers. We measured P-selectin expression and fibrinogen binding by flowcytometry at least 3 times over a period of 2 years in all the patients. We also studied 100 age- and sex-matched controls. RESULTS: Of the 60 patients, 30 (50%) showed both increased P-selectin and fibrinogen binding by platelets, suggesting platelet activation. Fourteen other patients had increased fibrinogen binding but normal P-selectin expression. Sixteen patients and all the controls had normal results of both tests. CONCLUSION: Our data show evidence of platelet activation in at least 50% of patients receiving 100 mg of aspirin daily. Flowcytometry for P-selectin expression and fibrinogen binding to platelets can be used to monitor antiplatelet therapy with aspirin following acute myocardial infarction.

Acute Disease↗