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Biomedical subjects

A Khan

Publications and source records attributed to A Khan.

At least 595 records · Page 33Linked to original sources
PubMed1978

Aortic valve replacement during acute rheumatic fever.

Emergency aortic valve replacement was performed during an attack of acute rheumatic fever in a 12-year-old black boy. He had an uneventful recovery and has remained asymptomatic 27 months after operation. In the light of this experience and that of others, one might conclude that the decision to operate on these patients should be based on the severity of the haemodynamic derangement rather than on the state of activity in the rheumatic process.

Acute Disease↗
PubMed1978

Thymic hormones and immunopeptides.

The role of the thymus and its hormones in immunity is discussed. The known characteristics of various thymic factors, their mode of action and possible clinical applications are also reviewed. A brief discussion of other immunopeptides which are liberated by lymphocytes is also included.

Aging↗
PubMed1978

The usefulness of transfer factor in asthma associated with frequent infections.

Fifteen patients underwent controlled trial with transfer factor for repeated infections and severe asthma. Marked decrease in respiratory infections and striking improvement in asthma resulted. The authors suggest that transfer factor may reconstitute immune function, thus representing a unique approach to severe asthma associated with frequent infections.

Adolescent↗
PubMed1977

Changes in the immunocompetence and surface markers of lymphocytes in stored blood.

Changes in lymphocyte responses to mitogens and other lymphocyte markers were studied during a 14-day period of storage of blood at 4 degrees C and 22 degrees C in plastic bags. The following tests were done: (a) absolute lymphocyte and neutrophil counts, (b) blastogenic response to PHA, PWM, Con-A, and LPS and (c) determination of T and B cells using E-rosette and EAC-rosette techniques. The neutrophils disappeared rapidly at 22 degrees C. The absolute lymphocyte count doubled in a week. The responses to PHA, PWM, and Con-A declined rapidly and were absent by the 6th day. The response to LPS disappeared on day 14. The ability to form E-rosettes and EAC-rosettes was lost by days 4 and 6, respectively. The results obtained at 4 degrees C were similar except that these changes were delayed varying from 1-7 days.

B-Lymphocytes↗
PubMed1977

Pineal calcification.

The incidence of pineal calcification was studied by reviewing skull radiographs of 1400 patients admitted to a major neurosurgical centre at Karachi over an eight year period. The total frequency as well as age and sex distribution of pineal calcification were worked out and compared with frequency and age distribution of calcification reported in Western and Eastern races by different workers.

Adult↗
PubMed1977

Patients with acute poisoning seen in the department of intensive care-Jinnah Postgraduate Medical Centre, Karachi.

A review of 157 cases of acute poisoning admitted to the intensive care unit shows that poisoning was responsible for 40 15% of the cases treated at this unit between 15th January to 31st December, 1976. Inspite of limited facilities the over all mortality from acute poisoning was 9.5% while that due to organo-phosphorus insecticides alone was 7%. A considerable infrequency of organophosphorus insecticides poisoning was observed in developed countries when their data was compared with the present series.

Adolescent↗
PubMed1976

Systemic lupus erythematosus in twin sisters following ten years of hyperglobulinemic purpura (Waldenström).

Uniovular twin sisters have been diagnosed 10 years ago as having hyperglobulinemic purpura (Waldenström) at age 12. The diagnosis was documented by purpura of the lower extremities, increased gamma-globulin after serum electrophoresis, and increased 7S component upon ultracentrifugation. In addition, there was an elevated ESR, a positive rheumatoid arthritis latex test, and their LE prep. was negative at that time. At a later date, however, both of them developed polyarthritis. After 9 years for the one and 10 years for the other, their LE prep. became strongly and constantly positive, while their gamma-globulin remained within abnormal limits.

Blood Proteins↗
PubMed1976

Increase in E-rosettes after transfer factor (TF) treatment: fractionation of TF.

The effect of transfer factor (TF) on E-rosettes (ER) was studied in vivo in a patient with Hodgkin's disease. Transfer factor was given in doses of 10 units/sq m intramuscularly. The ER forming cells and the ER scores were determined. The ER score method took into account the number of erythrocytes in each rosette. The increase in ER score was maximum at 24 hours and it declined during the following one to two weeks. It was suggested that TF may have to be given more frequently than indicated by the persistence of skin reactivity. TF was fractionated with high pressure liquid chromatography. Fraction 2 increased ER in a patient with Schwannoma. Non-specificity of TF was also discussed.

Adult↗