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Biomedical subjects

A Kh Alenova

Publications and source records attributed to A Kh Alenova.

10 recordsLinked to original sources
PubMed2002

[Informative value of polymerase chain reaction in the diagnosis of a tuberculous process].

The informative value of the polymerase chain reaction (PCR) in the diagnosis of a tuberculous process in patients with pulmonary and extrapulmonary tuberculosis was studied. Sputum, urine, pleural and spinal fluids, and other specimens from 111 patients and 14 healthy individuals were tested. An analysis of sputum from 58 persons clinically diagnosed as having tuberculosis showed the following comparative sensitivity of the used methods: 82.8%, PCR; 65.5%, bacterioscopy; and 67.2%, inoculation. The detection rate of specific DNA from different samples was the following: 82.8% from the sputum, 66.6% from urine, and 54.5% from pleural fluid. The informative value of PCR in 14 patients with osteoarticular tuberculosis and in 39 with urinary tuberculosis was 42.8 and 40.6%, respectively. Thus, the application of PCR to a comprehensive examination of patients with tuberculosis of different sites is justifiable.

Humans↗
PubMed2002

[Interaction of types of drug resistance and immunity in patients with pulmonary tuberculosis].

The authors carried out a comparative clinical and immunological study of different types of drug-resistance (mono-, poly-, MDR of primary and secondary genesis) and immunity in 54 patients with a specific process in the lung. The level of suppression, immunodeficiency, and the incidence of adverse effects were found to be on the increase in the group with the preserved sensitivity to the that with mono-, poly-, and MDR. Impaired immune homeostasis was more pronounced in patients with secondary MDR versus those with primary MDR.

Antitubercular Agents↗
PubMed2001

[HIV infection and tuberculosis in the Republic of Kazakhstan].

The incidence of HIV infection is now recorded in all 14 regions of the Republic of Kazakhstan and in the cities of Astana and Almaty. A total of 1010 HIV-infected persons were recorded as of January 1, 2000. There were 29 patients with AIDS. Tuberculosis was detected in 93 of the HIV-infected patients recorded as of January 1, 2000, which amounts to 12.5% of the examinees. It was found in 39 of the HIV-infected prisoners, which accounts for 41.9% of the total number of patients having a contaminant infection and for 19.4% of those convicted. However, it should be believed that these data do not reflect the true state of affairs, which involves some difficulties associated with the diagnosis of tuberculosis in patients HIV infection both in its early and late stages.

AIDS-Related Opportunistic Infections↗
PubMed1992

[Effectiveness of hyperbaric oxygenation in the treatment of postresection bronchial fistulas].

The article discusses the results of treatment of 84 patients with postresection tuberculous pyothorax and bronchial fistulas with hyperbaric oxygenation session (HBO) included in the complex of therapeutic measures. As a result, the bronchial fistulas closed in 30 (35.7%) patients, the diameter of the fistulas reduced markedly in 20 (24.3%) patients, the bronchial fistulas failed to close in 40% of cases. As the result of HBO therapy the count of red cells and lymphocytes increased, leukocytosis and eosinophilia reduced, the ESR diminished. The content of ALT transaminase, sugar, total protein and bilirubin decreased. The migration index for all immune antigens in the reaction of leukocyte migration inhibition and in the nitro blue tetrazolium test increased. HBO promoted the efficacy of radical operations by 29.4% as compared to that in the control group of the similar patients.

Bronchial Fistula↗
PubMed1989

[The use of hyperbaric oxygenation in the combined treatment of postresection tuberculous pleural empyema with bronchial fistulae].

The results of treating 67 patients with postresection tuberculous empyema of the pleura and bronchial fistulas are presented. The complex treatment included courses of hyperbaric oxygenation. The treatment procedure is described. Closure of the bronchial fistula and decrease in the fistula diameter were observed in 23 (33.8 per cent) and 16 (24.5 per cent) patients, respectively. No closure of the bronchial fistula in 41.7 per cent of the patients was recorded. Increased erythropoiesis, decreased leukocytosis and higher leukocyte counts, retarded ESR, lower contents of transaminases, increased inhibition of leukocyte migration, lower levels of immunoglobulin E and fewer numbers of immune complexes circulating in blood were revealed.

Adolescent↗
PubMed1989

[Immunologic indices of tuberculosis in pregnant women].

The results of immunological examination of 40 pregnant women recovered from tuberculosis and 7 healthy pregnant women are presented. The highest titers of antituberculous antibodies, the highest levels of leukocyte migration inhibition in response to tuberculin and the highest percentage of formazan-positive neutrophils were characteristic of the women recovered from tuberculosis. There was an increase in the indices by the pregnancy terms from the 36th to the 40th weeks. Simultaneous detection of the high indices of the immunological tests was prognostically unfavourable which could be used as a basis for arrangements on preventing tuberculosis aggravation during pregnancy.

Antibody Formation↗