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Biomedical subjects

A Keane

Publications and source records attributed to A Keane.

At least 37 records · Page 2Linked to original sources
PubMed1993

A study on in vitro glycation processes by matrix-assisted laser desorption ionization mass spectrometry.

The number of glucose molecules condensed on glycated bovine serum albumin have been easily determined by means of matrix-assisted laser desorption/ionization mass spectrometry. Measurements were carried out on samples from incubation of the protein with glucose at different concentrations (0.02 M, 0.2 M, 2 M and 5 M). A clear increase in molecular mass of BSA with respect to incubation time is detected. In contrast to what is observed with fluorescence, the plots of molecular mass increase vs. incubation time show the occurrence of a steady state, corresponding to the complete saturation of all the protein sites reactive against glucose. Comparison of fluorescence and molecular mass data reveals that some further reactions, different from condensation, must take place, which could be in principle either intramolecular or originated by reactivity of modified condensed glucose moieties vs. free glucose.

Glucose↗
PubMed1993

Tertiary nurse practitioners.

Tertiary nurse practitioners are proposed to meet the specialized health care needs of complex patients. Societal changes, increasing numbers of medically vulnerable people and increased costs of health care demand innovative responses to health care delivery. Nurse practitioners' effectiveness in primary care settings supports their introduction into acute care settings. Nurse practitioners are involved in tertiary care in response to a need for the delivery of care to patients with specialized needs. The evolution of the tertiary nurse practitioner role pre-dated the response of educational institutions to provide appropriate preparation for practitioners in tertiary care. Curricular imperatives and policy issues that will influence professional practice of the tertiary nurse practitioner are discussed.

Curriculum↗
PubMed1993

Nurses as house staff.

Explore the source record for details and available documents.

Health Services Accessibility↗
PubMed1991

Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case-control study.

The association between inhaled fenoterol and death from asthma has been investigated further by studying 112 asthma deaths (cases) during 1981-7 in patients aged 5-45 years who had been admitted to a major hospital for asthma during the 12 months before death. Two age matched control groups were chosen. Control group A comprised 427 patients who had been admitted to hospital for asthma during the calendar year that the corresponding death occurred and who had also had a previous admission for asthma in the previous 12 months. Control group B comprised 448 patients admitted to hospital for asthma during the calendar year in which the admission of the corresponding case occurred. The inhaled fenoterol odds ratio was 2.11 (95% confidence interval (CI) 1.37-3.23, p less than 0.01) when group A was used as the control (the approach used in previous studies), and 2.66 (95% CI 1.74-4.06, p less than 0.01) with group B as the control (the approach recommended by critics of previous studies). Markers of chronic asthma severity were associated with asthma death when control group B was used, but not when control group A was used (which indicates that these markers were indirectly matched for when control group A was used). Information was also collected on various markers of acute asthma severity and prescription of psychotropic drugs, but it was found that these were not important confounders. These findings address the major criticisms of previous case-control studies of this issue, and add support to the hypothesis that inhaled fenoterol increases the risk of death in patients with severe asthma.

Administration, Inhalation↗
PubMed1989

A serial study of anticardiolipin antibody and antimitochondrial antibody type M5 in a patient with polyarthritis and polymyositis.

A 22-year-old female presented with polyarthritis and subsequent polymyositis. Initially, she had moderately high levels of anticardiolipin (aCl) and antimitochondrial antibody (AMA) type M5. Following corticosteroid therapy, the anticardiolipin antibody rapidly fell to background levels but reappeared with the onset of two significant clinical events.

Adult↗
PubMed1987

Anticardiolipin antibodies in rheumatoid arthritis.

Anticardiolipin antibody (ACA) was present in the sera of 49% of 90 consecutive patients with rheumatoid arthritis (RA). The ACA was absent in 30 control patients with osteoarthritis. C-reactive protein levels equal to or exceeding 7 mg/dl were found in 10 patients all of whom were ACA positive. ACA was present in a larger proportion of rheumatoid factor (RF) positive than of RF negative patients. Male sex and extra-articular manifestations of RA were both more common in ACA positive than ACA negative patients. In the ACA positive group the lupus anticoagulant and VDRL tests were negative. However, a small number of patients had evidence of vascular events.

Adult↗
PubMed1985

Quality assurance. Evaluate thyself.

Quality assurance (qa) programs must be documented carefully, systematically, and completely to be of continued value. A literature review revealed that no tools had been developed to evaluate the effectiveness of qa programs. A tool was designed and tested to assess the reports of qa studies, as an initial step in establishing the benefits of qa. The tool was found to yield reproducible results and its use is recommended to others.

Hospital Bed Capacity, 500 and over↗
PubMed1984

"Why me?": an attributional analysis of a major illness.

The applicability of attribution theory in general, and Weiner's model in particular, to a medical setting was investigated. Patients undergoing thoracic surgery were interviewed before and after surgery to ascertain why they thought they had the disease and why they were recovering at an adequate or inadequate rate from the surgery. These data were analyzed to answer two primary questions. First, to what extent can Weiner's academically-based attribution model be applied to a medical setting? Secondly, do the attributions that patients make about the cause of their disease affect their ability to recover from it? The results indicated that Weiner's theory can be applied to this situation, although a modification in one major dimension of the theory (the Locus dimension) seems warranted. In addition, the causal attributions that patients made about their disease correlated with recovery, although the pattern of attributions for successful patients was complex and theoretically ambiguous. Suggestions for modifying Weiner's model to make the theory more applicable to a medical setting are presented.

Adult↗
PubMed1978

The momentum of population growth with time dependent net maternity function.

The momentum of population growth problem of Keyfitz is generalized to contain a gradual change of the age-specific birth rate ro the level of bare replacement. Assuming a time dependence for the net maternity function of the form (formula: see text) R being the net reproductive rate, we show that for the Malthusian model the asymptotic birth rate is increased by exp (r/lambda), where r is the rate of increase of the population before t = 0. A numerical method for obtaining the asymptotic birth rate for a general net maternity function with the same time dependence is outlined.

Age Factors↗
PubMedDate not supplied

A model of survivors' psychological responses following a residential fire.

Residential fires result in loss of life, property, and displacement from one's neighborhood. It would be expected that grief experienced in the aftermath of residential fires has a significant impact on survivor's recovery and reintegration into the community. Although there is some research on psychological responses to community-wide fires and large scale disasters, little is known about such responses among survivors of home fires that occur episodically. Appropriate interventions cannot be developed until more is learned about variables influencing survivors' psychological response to a residential fire. A theoretical model of survivors' psychological response post-fire is proposed.

Disasters↗
PubMedDate not supplied

Demographic characteristics, fire experiences, and distress of residential fire survivors.

The United States has one of the highest per capita fire death rates in the world. Death rates alone, however, fail to reflect the breadth of loss experienced by residential fire survivors. Despite the frequency of home fires and the potential for loss, little is known about this vulnerable population. Interviews were conducted with 440 fire survivors 14 weeks after fires. Demographic characteristics of residential fire survivors, survivors' fire experiences, psychological distress after fires and the interrelationships among these variables were examined. This sample of urban fire survivors largely comprised poor, middle-aged African American women. Psychological distress was measured by the General Severity Index of the Brief Symptom Inventory, and the results showed that survivors were highly distressed, even in the absence of fire-related death or physical injury.

Adolescent↗