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Biomedical subjects

A Kataoka

Publications and source records attributed to A Kataoka.

At least 109 records · Page 6Linked to original sources
PubMed1990

[A study of localizations and serum data; four tumor markers (CA125, CA19-9, CEA and TPA) in ovarian cancers].

Four tumor markers (CA125, CA19-9, CEA, TPA) were analysed between the localizations and the serum data in the 36 ovarian cancers. The positive rates of each tumor markers were; 23 cases (63.9%) on CA125, 15 cases (41.7%) on CA19-9, 12 cases (33.3%) on CEA, and 27 cases (75.0%) on TPA. CA125 and CA19-9 were observed in the luminar borders and cellular membranes on serous adenocarcinomas and in the cytoplasms on mucinous adenocarcinomas. Both CEA and TPA were stained in cytoplasms. The correlation in the localization was observed between CA19-9s and CEAs (Kendall's rank correlation = 0.5303 greater than 0.5). The correlations between the localization and the serum data were observed on CA19-9 and CA125.

Adenocarcinoma, Mucinous↗
PubMed1990

[Work load of nursery teachers in a nursery school. Relationship between age of children and work load].

Time study of six nursery teachers of children aged 0 to 5 was conducted at a public nursery school to ascertain their work load, and the results obtained were examined from the following two viewpoints. First, comparison was made between the results obtained by the following two methods of analysis; 1) An observer recorded the work contents and the working postures of a nursery teacher at place of work in one-minute units. 2) The nursery teacher was recorded on video tape and the analysis of the work contents and the working postures was made in one-second units. Second, comparison was made between the work loads (work content, working posture, walking, lifting children and recess) of nursery teachers of children of different age group. The results could be summarized as follows: 1. The results of analysis made by the two methods of the work contents and the working postures were in good agreement. 2. The higher the age of children in the class, the longer was the cumulative time for "indoor group nurture" and the shorter was the cumulative time for "help and care for feeding", "help and care for afternoon nap" and "help and care for excretion". 3. The higher the age of children in the class, the longer was the cumulative time of "standing" in a nursery teacher and the shorter was the cumulative time of "sitting on the floor". The total time of "bending forward", "squatting" and "rising on the knee" occupied 20% of the working hours on an average and was not related clearly to the age of children. 4. The frequency of walking was not found to be related to the age of children. 5. The nursery teachers of children aged 0 and 1 lifted children much more frequently among all nursery teachers. 6. The recess away from children was rarely observed throughout the day.

Age Factors↗
PubMed1990

Detection and typing of human papillomavirus infection of uterine cervix in young women by non-isotopic subgenomic probes on Southern blot--a report of studies in Sweden.

Human papillomavirus (HPV) was detected by non-isotopic subgenomic probes on Southern blot hybridization (Oncor Inc., Gaithenberg, MD). The 108 samples which were obtained from patients below the age of 30 (mean age 19.0 +/- 2.8 yrs). All samples were collected from the ectocervical mucosa by Cytobrush (Medscand, Malmö, Sweden) as previously described. HPV-DNA was detected in 16 cases (15%). In 36 cases (33%) the patients presented clinical findings of condyloma or cervical intra-epithelial neoplasia (CIN) at simultaneous vaginal ectocervical smears. HPV-DNA was detected in 12 out of 36 cases. On the other hand, in the patients without subclinical findings HPV-DNA were detected in only 4 out of 70 cases (6%). HPV-DNA was detected in one of the 4 patients with accuminate condyloma of the cervix and in 4 out of 16 cases with similar lesions in the vulva. The only HPV type found in these patients was type 6. Papillomavirus was also detected in 5 out of 16 cases (31%) with flat condylomas, most studied types being represented here. CIN was only reported two patients both of them carrying HPV-DNA (types 16 and 18 respectively). The most common type of virus was HPV 6. Combined infections with two or three types were seen in 5 out of 16 HPV-positive cases (31%). Such cases are readily detected and typed with the present Southern blot procedure, where the use of subgenomic probes enables the distinction of all types, even when present in the same sample.

Adolescent↗
PubMed1990

[A study of amplifications of myc gene (c-myc and N-myc) in human ovarian cancer].

Amplifications of myc oncogenes (c-myc, N-myc) were studied by Southern blot hybridization methods in ovarian cancers. Fourteen cases were primary ovarian cancers and one case was metastatic ovarian cancer. Primary and metastatic foci of three primary ovarian cancers were compared. A serous adenocarcinoma had a c-myc gene amplification more than 10 fold without N-myc gene amplification. This case also had an amplification in other c-myc probes with upper and down streams of the second exon. The results suggested that this case had c-myc gene expression. One of these cases had 5 fold amplification of the metastatic focus compared with the primary focus. The amplified c-myc gene did not show relations among clinical courses, prognosis and histologies.

Adult↗
PubMed1989

[Analysis of the treatment of pseudomyxoma peritonei--cytoreductive surgery with chemotherapy and intraperitoneal inoculation after washing with dextran].

Twelve cases of pseudomyxoma peritonei in the Department of Obstetrics and Gynecology in Kurume University School of Medicine were categorized in three groups by treatment; 3 cases with just operations, 6 cases with chemotherapies after operations and 3 cases with chemotherapies and intraperitoneal inoculations of cisplatin after washing with dextran. These treatments were analyzed by their survival rates. As to the cases repeated operations, the second look laparotomy was estimated as a cytoreductive surgery, including a prior chemotherapy. Ten of 13 chemotherapeutic courses were effective in the 6 cases with second look laparotomies and five of 6 cases were living without tumor. We confirm the treatment of the intraperitoneal inoculation of cisplatin after dextrose washing with the cytoreductive surgery is one of the most effective therapies for pseudomyxoma peritonei.

Adult↗
PubMed1989

[Clinicopathological study of pseudomyxoma peritonei].

Twelve cases of pseudomyxoma peritonei in Kurume University Hospital and its affiliated hospitals were clinicopathologically analysed. The patients were 42 to 81 years old, and the averaged age was 65.1 years. One case was before menopause. As to past history, one had undergone simple hysterectomy for myoma uteri previously, another patient (No. 8) was diagnosed as having mucinous adenocarcinoma of the appendix and two others (cases No. 2 and 7) had had treatment for pleurisy and peritonitis. Histologically, 3 cases were diagnosed as benign, 4 were borderline malignancy, and 5 were frankly malignant. Six cases were cytologically examined. Four of 6 were recognized as malignant cases. It was thought the diagnosis should be done by both cytological and radiological examination. It was suggested by the past history and histological infiltration of inflammatory cells in cases No. 2 and 7 that the histogenesis of pseudomyxoma peritonei was related to the inflammation with mucinous tumors. The relationship between histological findings and prognosis was unclear. Three cases were treated by surgery only, 6 cases by surgery and chemotherapy, and the other 3 cases by surgery, chemotherapy and washing intraperitoneally with dextran. The five year survival rate for cases treated by surgery and chemotherapy was 40.0%, including 2 patients still living more than 10 years later. All three cases treated by washing intraperitoneally with dextran survived, but for less than 5 years. The result of treatment by washing with dextran was thought to be an effective therapy for pseudomyxoma peritonei.

Adenocarcinoma, Mucinous↗
PubMed1989

[Effects of anticancer agents on 7, 12-dimethylbenz (a) anthracene induced rat ovarian cancer cell line (DMBA-OC-1) and human ovarian serous adenocarcinoma cell line (KOC-1S)].

The antitumor activities of five anticancer drugs, at IC50 dosages cisplatin (CDDP), adriamycin (ADM), etoposide (VP-16), mitomycin C (MMC) and carboplatin (CBDCA) were studies an 7,12-dimethylbenz (a) anthracene induced rat ovarian cancer cell line (DMBA-OC-1) and a human ovarian serous adenocarcinoma cell line (KOC-1S). The IC50 dosage of anticancer drugs for DMBA-OC-1 was: CDDP 0.2 microgram/ml. ADM 0.04 microgram/ml, VP-16 3.0 microgram/ml, MMC 0.1 microgram/ml and CBDCA 10.0 micrograms/ml. The results of our study except those for MMC were parallel with those published on in vivo studies. The IC50 dosages of DMBA-OC-1 did not have enough antitumor activity for KOC-1S, whereas the original KOC-1S tumor strongly resisted the combination chemotherapy (CDDP, ADM and cyclophosphamide). Therefore, our findings suggested the possibility of the separation of multiple drug resistant clones from KOC-1S. These two cell lines had quite different antitumor activity characteristics.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1989

[Clinicopathological study of malignant ovarian germ cell tumor].

In treating malignant germ cell tumors clinicopathologically at Kurume University Hospital, for 18 years, the total number of patients was 112, including 25 yolk sac tumors (YST), 10 mixed form germ cell tumors (MF), 36 dysgerminomas (DYS), 26 immature teratomas (IT), 2 choriocarcinomas (CHO) and 13 dermoid cysts with malignant transformation (DCMT). The average age of patients in each group was 25.9 years for DCMT patients. When DCMT cases were excluded, ages was closely related to the age of menarche in each patient. The 5 year survival rate for each germ cell malignancy after the first operation was 31.6% for YST cases, 20.0% for MF, 76.7% for DYS, 60.0% for IT and 50.0% for DCMT cases. Despite currently used aggressive kinds of chemotherapy, the clinical stage still had a prognostic significance in all malignant germ cell tumors except dysgerminoma. Since histological maturation of the tumor tissue following treatment courses was observed in YST and IT cases, the possibility of a relationship between prognosis and the histogenetic process was shortly discussed.

Adolescent↗
PubMed1988

Heterotransplantation of an alpha-fetoprotein-producing human gallbladder carcinoma into nude mice.

An alpha-fetoprotein (AFP)-producing human gallbladder carcinoma showing direct invasion into the liver was transplanted into BALB/c-nu/nu nude mice. Although patient serum levels of AFP and carcinoembryonic antigen (CEA) were within normal limits, they were elevated to 1,040 ng/ml and 22.1 ng/ml, respectively, after cholecystectomy. Prominent liver metastasis was demonstrated by diagnostic imaging techniques shortly after the operation. Pathologically, the resected tumor consisted of papillotubular adenocarcinoma and the part which had invaded the liver showed a solid growth pattern with no papillo-tubular structure. The transplanted tumor showed both papillo-tubular and solid growth patterns, in which positive reactions for AFP, CEA, ferritin (FER), carbohydrate antigen 19-9 (CA 19-9), albumin (ALB) and fibrinogen (FIB) were confirmed by the avidin-biotin-peroxidase complex method. Serum levels of AFP, CEA, CA 19-9, beta 2-microglobulin (BMG) and FER were elevated in the nude mice bearing tumor transplants. Twenty-five percent of the serum AFP from nude mice with tumor transplants bound with concanavalin A (Con A), suggesting that the tumor was of gastrointestinal rather than hepatic origin.

Adenocarcinoma↗
PubMed1987

Establishment and morphologic characterization of a cell line (DMBA-OC-1) from 7,12-dimethylbenz(a)anthracene-induced rat ovarian carcinoma.

A new cell line (DMBA-OC-1) from 7,12-dimethylbenz (a) anthracene (DMBA) which induced ovarian carcinoma in rat was established and characterized. DMBA-OC-1 cells showed a paving-stone-like growth pattern at around the 10th to 20th passage, but at the point exceeding the 40th passage the cells showed a spindle form, having strong trends both towards flocculation and piling-up. Furthermore, diastase-resistant PAS-positive and hyaluronidase-digested Alcian blue positive substances were observed in cytoplasms. The cells also showed marked phagocytic activity. These findings suggest that DMBA-OC-1 cells are most likely the site of mesothelial cell origin.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1986

Heterotransplantation of ovarian serous adenocarcinoma with functioning stroma to nude mice. Disappearance of functioning stroma in transplanted tumor.

Serous adenocarcinoma of the ovary with estrogen and alpha-fetoprotein (AFP) production was serially heterotransplanted into nude mice. The original tumor presented marked luteinization of stromal cells with elevated urine levels of estrogen before the operation. Estrogen levels reduced to the normal level shortly after the operation. Histologic features of the original tumor were basically retained in the transplanted tumor, but no luteinization of stromal cells was observed and serum estrogen levels in nude mice were elevated. Immunohistochemically, AFP was found to be positive in some tumor cells of transplanted tumor, but serum AFP levels were not elevated.

Adenocarcinoma↗