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Biomedical subjects

A Kahn

Publications and source records attributed to A Kahn.

At least 577 records · Page 32Linked to original sources
PubMed1978

The cell surface.

Explore the source record for details and available documents.

Binding Sites↗
PubMed1978

[Comparative study of acute poisonings in Belgian children and immigrant workers children].

This survey covers 786 children admitted with acute poisoning to the Saint-Pierre Hospital in Brussels between 1967 and 1976. The type and the frequency of products responsible for poisoning in the indigenous and immigrant children are compared. 45% of children admitted to hospital are immigrants but they constitute only 29% of the children admitted with poisoning. When compared with Belgian children, the immigrants more commonly ingest household products and ordinary drugs are taken more often than prescribed ones, but minor tranquillisers are particularly common. The socio-economic and psychologic factors responsible for these accidents are discussed and methods of prevention are suggested.

Acute Disease↗
PubMed1978

Patterns of primary thyroid failure.

Serum thyroxine(T4), triiodothyronine (T3) and thyroid-stimulating hormone (TSH) levels were measured in 170 patients with suspected hypothyroidism. Only patients with elevated serum TSH levels indicative of some degree of primary thyroid failure were included in the study. They appeared to represent four distinct classes of thyroid failure: class 1 (19.5%) had normal T4 and normal T3; class 2 (8%) had low T4 and elevated T3; class 3 (37%) had low T4 and normal T3; and class 4 (35.5%) had low T4 and low T3. TSH levels were increased in all classes. Of 10 patients who were followed without treatment and evaluated after three and six months, six showed increasing clinical and chemical evidence of hypothyroidism and were reclassified, two did not progress and two patients improved. Our study showed that serum T3 levels may be normal or even elevated in hypothyroidism and, therefore, are not a useful indicator. The data also suggested that serum T4 is the main determinant of the metabolic state of the patient, since class 3 patients, the largest single group, had normal serum T3 levels despite striking clinical evidence of hypothyroidism. Thus, a normal serum T3 in the absence of a normal serum T4 is not generally sufficient for maintenance of a euthyroid state. Finally, our study showed that in primary thyroid failure there is better reciprocal correlation between the levels of serum TSH and T4 than between those of serum TSH and T3.

Adult↗
PubMed1977

'Gd(-) Hôtel Dieu': a new G-6PD variant with chronic hemolysis in a Negro patient from Senegal.

A G-6PD deficiency was detected in a Negro patient from Senegal suffering from congenital nonspherocytic hemolytic anemia. The main characteristics of this variant were: profound defect of G-6PD activity in the red cells, decreased immunologic specific activity, fast electrophoretic mobility, decreased Km-G-6P and normal Km-NADP+, normal inhibition by ATP and NADPH, slightly increased utilization of the substrate analogues, slightly biphasic pH curve, high heat lability, subnormal activation energy. The characteristics of this variant being unique, it was called 'G-6PD Hôtel Dieu.'

Adult↗
PubMed1977

Human erythrocyte pyruvate kinase. Total purification and evidence for its antigenic identity with L-type enzyme.

Erythrocyte pyruvate kinase (ATP:pyruvate 2-0-phosphotransferase, EC 2.7.1.40) has been purified 40 000 times from human erythrocytes, according to an original method. The whole purification procedure included toluene extraction, ammonium sulphate fractionation, DEAE-Sephadex batchwise chromatography and affinity chromatography on a Dextran Blue-Sepharose column with specific elution by fructose 1,6-diphosphate. The final preparation had specific activity of 290 I.U./mg of proteins and the overall yield was about 30%. Pyruvate kinase showed only one protein band as judged by sodium dodecyl sulphate acrylamide gel electrophoresis. Pure enzyme was injected into rabbits and monospecific antiserum was obtained able to neutralize, per ml, 150 I.U. of erythocyte-type pyruvate kinase as well as of L-type enzyme. L-type and erythrocyte-type pyruvate kinases showed reactions of complete identity when tested in immunodiffusion against anti-erythrocyte type pyruvate kinase sera; in all cases a single precipitation line could be detected. L-type pyruvate kinase when mixed with anti-erythocyte pyruvate kinase serum suppressed all ability of that antiserum to react immunological with erythocyte enzyme. Finally the microcomplement fixation curves using anti-erythrocyte pyruvate kinase serum were identical for erythrocyte and L-type enzymes. From these results it appeared that no antigenic difference between L-type and erythocyte enzyme could be detected. Consequently the most likely hypothesis is that both these enzymes are coded by the same single gene, the slight electrophoretic differences between them being due to post-synthetic tissue-specific changes.

Antigens↗