Search PubMed⌕ Search

Biomedical subjects

A K Zagorul'ko

Publications and source records attributed to A K Zagorul'ko.

At least 19 recordsLinked to original sources
PubMed1993

[The role of hypoxic-hypercapnic training in reducing local protective factors of the lung in a chronic inflammatory process in bronchopulmonary tissue under experimental conditions].

The effect of hypoxic-hypercapnic trainings (HHT), conducted before the induction of inflammation or started at next day after foreign body bringing, was shown in experiment on rats with chronic inflammation process in bronchopulmonary tissue. HHT conducted before the induction of inflammation in general had an favourable effect. HHT conducted later had a positive effect together with expressed negative changes, in particular worsening of inflammation process in lung.

Animals↗
PubMed1991

[The effect of the chemical composition of the bile and calculi on the morphological changes in the gallbladder].

The authors carried out a morphological study of the gallbladder wall, as well as the bile and concrements by the method of infrared spectroscopy in 54 patients (9 men, 45 women) operated on for cholelithiasis. A certain relationship was found between the morphofunctional state of the gallbladder wall and biochemical composition of the bile and concrement. This allows to use infrared spectroscopy for evaluation of the morphofunctional state of the gallbladder wall.

Adult↗
PubMed1991

[Ultrastructural morphology of the air-blood barrier and pulmonary surfactant in pulmonary inflammation in experimental alcoholic intoxication].

Combined investigation of ultrastructure of components of air-haematic barrier and surface-active properties of surfactant in 21 guinea pigs' lungs with simulated pneumonia against a background of alcoholic intoxication was carried out. It was established, that alcoholic intoxication aggravates a deficiency of pulmonary surfactant occurred in pneumonia because of its high phagocytosis with alveolar macrophages. The increase of mobilization of alveolar macrophages in alcoholic intoxication may be connected with the rise of surfactant secretion by hyperfunctional pneumocytes of the 2nd type. Stopping of alcoholic intoxication may lead to normalization of qualitative composition of surfactant phospholipids.

Alcoholic Intoxication↗
PubMed1990

[Pulmonary surfactant system of newborn rats in alcoholic intoxication of pregnant rats].

Data, received in investigation of the lungs of 45 newborn rats, show, that there is the suppression of the surface active properties of surfactant in animals, born from female rats with simulated alcoholic intoxication in pregnancy period. The decrease of the surface activity of surfactant may be connected with direct injury influence of alcohol on surfactant as well as with inactivation of surfactant with serum proteins, which appear in the alveolar space because of the increase of the permeability of components of air-haematic barrier. The suppression of the surface active properties of surfactant is accompanied by reinforcement of the functional activity of the 2nd type pneumocytes and appearance of the hypertrophic forms of these cells.

Animals↗
PubMed1990

[The pulmonary surfactant status in lung immaturity].

Combined study of lungs of 85 foetuses and newborns of various gestational age and 8 newborns dying during the first month of life showed the lung surfactant (LS) system to develop in parallel with formation of respiratory parts and lung capillary network. The level of the LS surface activity increases with the increase of the duration of pregnancy and is determined by the maturation degree of the type II alveolocytes. Changes of the surface activity of the lung extract surface-active fraction in the process of lung maturation correlate with the fractional phospholipid distribution. Morphofunctional immaturity of lungs is characterized, besides histological features, by the ultrastructural immaturity of the type II alveolocytes and biochemical immaturity of LS.

Chemical Phenomena↗
PubMed1990

[Changes in surface activity of surfactant and ultrastructure of the air-blood barrier in alcoholic intoxication in experimental animals].

In the results of complex investigation of the lungs of 26 white rats, it was established, that there is the suppression of surface active properties of surfactant under influence of ethanol. In acute poisoning this suppression is associated with direct injury of surfactant with ethanol and inactivation of surfactant with serum proteins, which appear in the alveolar space because of the edema of air-haematic barrier. In prolonged influence the suppression of the surface activity of surfactant is due to the increase of its catabolism with alveolar macrophages.

Alcoholic Intoxication↗
PubMed1989

[Surfactant surface activity and ultrastructural changes in the type-II alveolocytes of fetal and neonatal lungs in experimental inflammation of the maternal lungs].

The lungs of 19 guinea pigs, born from 8 females in which acute and chronic pneumonia had been modelled by transtracheal introduction of sterile fishing-line were investigated. It was established, that in guinea pigs, born in females with acute and chronic pneumonia, the functional immaturity of pneumocytes of the 2-nd type took place. The functional immaturity of pneumocytes of the 2-nd type results in suppression of the surface active characteristics of surfactant.

Animals↗
PubMed1988

[Ultrastructure of the blood-air barrier in comparison with the indices of surfactant surface activity].

Ultrastructure of the air-blood barrier and surface surfactant activity were studied at different time periods of nonspecific inflammation of the lungs in guinea pigs. The animals were sacrificed 3 days, 2 weeks and 1, 2 and 4 months after beginning of the experiment. It has been demonstrated that in early periods of lung inflammation there was edema of all components of the air-blood barrier. Subsequent development of inflammation is accompanied by surface activity decrease associated with dystrophic changes in the epithelial cells of alveoli. At the same time there are compensatory changes in the lungs, directed to eliminate deficiency of surfactant.

Animals↗
PubMed1986

[Surface activity of the surfactant in experimental compression atelectasis].

Surface surfactant activity was studied at different time periods of compression atelectasis, induced by hydrothorax in 35 guinea pigs. The animals were slaughtered 30 and 60 minutes or 3, 12 and 24 hours after hydrothorax. It has been demonstrated that experimental compression atelectasis is accompanied by surface activity lowering, associated with disorders in surfactant secretion into the alveolar lumen. The qualitative composition of surfactant phospholipids remains unchanged, which may play an essential role in the recovery of lung tissue aeration.

Animals↗